{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T16:24:00Z","timestamp":1784910240125,"version":"3.55.0"},"reference-count":63,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003970","name":"isfahan university of medical sciences","doi-asserted-by":"publisher","award":["398572"],"award-info":[{"award-number":["398572"]}],"id":[{"id":"10.13039\/501100003970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Introduction<\/jats:title>\n<jats:p>Linguistic disorders are one of the common problems in Alzheimer\u2019s disease, which in recent years has been considered as one of the key parameters in the diagnosis of Alzheimer (AD). Given that changes in sentence processing and working memory and the relationship between these two activities may be a diagnostic parameter in the early and preclinical stages of AD, the present study examines the comprehension and production of sentences and working memory in AD patients and healthy aged people.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Twenty-five people with mild Alzheimer\u2019s and 25 healthy elderly people participated in the study. In this study, we used the digit span to evaluate working memory. Syntactic priming and sentence completion tasks in canonical and non-canonical conditions were used for evaluating sentence production. We administered sentence picture matching and cross-modal naming tasks to assess sentence comprehension.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The results of the present study revealed that healthy elderly people and patients with mild Alzheimer\u2019s disease have a significant difference in comprehension of relative clause sentences (P &lt;0.05). There was no significant difference between the two groups in comprehension of simple active, simple active with noun phrase and passive sentences (P&gt; 0.05). They had a significant difference in auditory and visual reaction time (P &lt;0.05). Also there was a significant difference between the two groups in syntactic priming and sentence completion tasks. However, in non-canonical condition of sentence completion, the difference between the two groups was not significant (P&gt; 0.05).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The results of the present study showed that the mean scores related to comprehension, production and working memory in people with mild Alzheimer\u2019s were lower than healthy aged people, which indicate sentence processing problems at this level of the disease. People with Alzheimer have difficulty comprehending and producing complex syntactic structures and have poorer performance in tasks that required more memory demands. It seems that the processing problems of these people are due to both working memory and language problems, which are not separate from each other and both are involved in.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0266552","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T17:25:54Z","timestamp":1667323554000},"page":"e0266552","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Investigating sentence processing and working memory in patients with mild Alzheimer and elderly people"],"prefix":"10.1371","volume":"17","author":[{"given":"Maryam","family":"Nasiri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeideh","family":"Moayedfar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3889-1876","authenticated-orcid":true,"given":"Mehdi","family":"Purmohammad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7550-3372","authenticated-orcid":true,"given":"Leila","family":"Ghasisin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,11,1]]},"reference":[{"key":"pone.0266552.ref001","author":"NL Mace","year":"2017","journal-title":"The 36-hour day: A family guide to caring for people who have Alzheimer disease, other Dementias, and memory loss: JHU Press;"},{"issue":"1\u20132","key":"pone.0266552.ref002","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cognition.2003.11.002","article-title":"Jaeger JJJC. 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