{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:51:00Z","timestamp":1790661060355,"version":"4.1.0"},"reference-count":15,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T00:00:00Z","timestamp":1656288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Project of Fenghua Science and Technology Bureau","award":["20186515"],"award-info":[{"award-number":["20186515"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>This study aims to evaluate the efficacy and safety of oxycodone hydrochloride (OxyContin) rectal administration in cancer pain patients. This is geared towards providing the research evidence for a novel route of OxyContin administration.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Relevant randomized controlled trials (RCTs) were searched in electronic databases, including PubMed, Cochrane Library, Web of Science, EMBASE, China National Knowledge Infrastructure (CNKI), Chinese Scientific Journal Database (VIP database), Wanfang Data Knowledge Service Platform, and Chinese Biomedical Literature Database (CBM). Moreover, unpublished academic data were obtained by contacting the colleague, professor, or Institute of Traditional Chinese Medicine. The RCTs of transrectal Oxycodone administration of sustained-release tablets for moderate and severe pain patients were searched in the databases from inception to December 2020.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>According to the inclusion criteria, a total of 8 RCTs were included, with a total of 648 patients. Meta analysis results showed that there was no statistically significant difference in the efficacy of moderate to severe pain control between the rectal administration group and the oral administration group (RR = 1.04, 95%CI: 0.99\u20131.10, p = 0.13&gt;0.05). At the same time, the incidence of adverse reactions in the rectal administration group was low. In terms of constipation, the rectal administration group was less than the oral administration group, with a statistically significant difference (RR = 0.43, 95%CI: 0.31\u20130.58, p&lt; 0.00001). In terms of nausea and vomiting, the rectal administration group was less than the oral administration group, and the difference was statistically significant(RR = 0.30, 95%CI: 0.21\u20130.42, p&lt;0.00001). In terms of sleepiness, there was no significant difference between the two groups(RR = 0.54, 95%CI: 0.26\u20131.15, p = 0.11&gt;0.05). In terms of dizziness, there was no statistically significant difference between the two groups (RR = 0.43, 95%CI:0.27\u20130.68, p = 0.31&gt;0.05). In terms of dyuria, there was no statistically significant difference between the two groups (RR = 0.37, 95%CI: 0.02\u20137.02, p = 0.51&gt;0.05). In terms of KPS scores there was no significant difference was noted between the rectal and oral administration groups (RR = 1.04, 95%CI: 0.89\u20131.21, p = 0.63&gt;0.05).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>In summary, we found no significant differences in efficacy between rectal administration of OxyContin and oral administration. Thus, rectal administration should be considered in managing cancer pain among patients with difficulty in oral OxyContin administration.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>PROSPERO registration number<\/jats:title>\n<jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?ID=CRD42021209660\" xlink:type=\"simple\">CRD42021209660<\/jats:ext-link>.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0266754","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T17:29:29Z","timestamp":1656350969000},"page":"e0266754","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Meta-analysis of efficacy and safety of sustained release oxycodone hydrochloride rectal administration for moderate to severe pain"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3644-3415","authenticated-orcid":true,"given":"Xian Bing","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan Dan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong Fei","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao Jun","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bi Xian","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan Yuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Zhou","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,6,27]]},"reference":[{"issue":"4","key":"pone.0266754.ref001","first-page":"176","article-title":"Cut points for mild, moderate, and severe pain among cancer and non-cancer patients: a literature review","volume":"4","author":"A Woo","year":"2015","journal-title":"Ann Palliat Med"},{"key":"pone.0266754.ref002","unstructured":"NCCN Clinical Practice Guidelines in Adult cancer pain (2019 Version 3) [DB\/OL]. http:\/\/www.nccn.org"},{"key":"pone.0266754.ref003","first-page":"218","volume-title":"Practical Oncology Internal Medicine","author":"JC Zhou","year":"2005","edition":"2"},{"issue":"11","key":"pone.0266754.ref004","first-page":"66","article-title":"Efficacy of oxycontin in the treatment of severe cancer pain by rectal administration","volume":"40","author":"Y L. Zhang","year":"2013","journal-title":"Chinese Journal of Practical Medicine"},{"issue":"06","key":"pone.0266754.ref005","first-page":"19","article-title":"Effects of oxycodone hydrochloride controlled-release tablets on cancer-relate pain following different routes of administration","volume":"53","author":"W H Yin","year":"2013","journal-title":"Journal of Nanchang University(Medical Sciences)"},{"issue":"32","key":"pone.0266754.ref006","first-page":"7","article-title":"The analysis of curative effect of oxycodone hydrochloride prolonged-release tablets in the treatment of cancer pain by rectally administered","author":"H B Wu","year":"2014","journal-title":"Chinese and Foreign Medical Research"},{"issue":"2","key":"pone.0266754.ref007","first-page":"57","article-title":"OxyContin to observe the safety and efficacy of drug treatment of cancer pain","volume":"30","author":"Q Y. Han","year":"2017","journal-title":"Medical Information"},{"issue":"17","key":"pone.0266754.ref008","first-page":"2193","article-title":"Effect of rectal administration of hydroxycodone hydrochloride sustatined-release tablets on cancer pain","volume":"25","author":"W X. Chen","year":"2018","journal-title":"Chin J Prim Med Pharm"},{"issue":"12","key":"pone.0266754.ref009","first-page":"1917","article-title":"Clinical observation of oxycodone hydrochloride prolonged-release tablets on moderate to severe cancer pain following different routes of administration","volume":"26","author":"H B Liu","year":"2018","journal-title":"Modern Oncolog"},{"issue":"7","key":"pone.0266754.ref010","first-page":"106","article-title":"Comparison of effects and adverse reactions of oxycodone hydrochloride sustained release tablets by different administration routes","volume":"4","author":"M Liu","year":"2019","journal-title":"Doctor"},{"issue":"5","key":"pone.0266754.ref011","first-page":"82","article-title":"The effect of opioid analgesics on severe pain caused by radiation stomatitis","volume":"27","author":"Du Yajuan","year":"2020","journal-title":"Contemporary Nurse (Shanghai)"},{"key":"pone.0266754.ref012","first-page":"13","article-title":"Taxonomy and classification of chronic pain syndromesPractical management of pain","author":"H Merskey","year":"2014","journal-title":"Mosby"},{"issue":"10","key":"pone.0266754.ref013","first-page":"CD007753","article-title":"Acupuncture for cancer pain in adults","author":"CA Paley","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"issue":"5","key":"pone.0266754.ref014","first-page":"1115","article-title":"Research progress of rectal drug delivery system","volume":"9","author":"Li Fei","year":"2019","journal-title":"Proprietary Chinese medicine"},{"issue":"12","key":"pone.0266754.ref015","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1111\/j.2042-7158.1988.tb06293.x","article-title":"Enhanced bioavailability of morphine after rectal administration in rats","volume":"40","author":"Y Katagiri","year":"1988","journal-title":"J Pharm Pharmacol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0266754","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T17:30:06Z","timestamp":1656351006000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0266754"}},"subtitle":[],"editor":[{"given":"Girish","family":"Sailor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,6,27]]},"references-count":15,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,6,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0266754","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,27]]}}}