{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T01:26:15Z","timestamp":1783041975207,"version":"3.54.6"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T00:00:00Z","timestamp":1649808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Scientific promotion program, Jeju National University.","award":["2022"],"award-info":[{"award-number":["2022"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>Although the role of obesity-induced metabolic abnormalities in impaired lung function is well-established, the risk of impaired lung function among obese individuals without metabolic abnormalities, referred to metabolically-healthy obesity (MHO), is largely unexplored. Therefore, we evaluated the impact of MHO on lung function in a large health-screening cohort.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>114,143 subjects (65,342 men, mean age and BMI: 39.6 years and 23.6) with health examinations in 2019 were divided into four groups as follows: metabolically healthy non-obese (MHNO), MHO, metabolically unhealthy non-obese (MUHNO), and metabolically unhealthy obese (MUHO). Metabolic health was defined as fewer than two metabolic syndrome components. Obesity was defined as BMI \u226525 kg\/m<jats:sup>2<\/jats:sup>. Adjusted odds ratios (aORs), using MHNO as a reference, were calculated to determine lung function impairment.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Approximately one-third (30.6%) of the study subjects were obese. The prevalence of MHO was 15.1%. Subjects with MHO had the highest FEV1% and FVC% values but the lowest FEV1\/FVC ratio (<jats:italic>p<\/jats:italic>&lt;0.001). These results persisted after controlling for covariates. Compared with MHNO, the aORs (95% confidence interval) for FEV1% &lt; 80% in MHO, MUHNO and MUHO were 0.871 (0.775\u20130.978), 1.274 (1.114\u20131.456), and 1.176 (1.102\u20131.366), respectively (P for trend = 0.014). Similarly, the aORs in MHO, MUHNO, and MUHO were 0.704 (0.615\u20130.805), 1.241 (1.075\u20131.432), and 1.226 (1.043\u20131.441), respectively, for FVC% &lt; 80% (p for trend = 0.013). However, the aORs for FEV1\/FVC&lt;0.7 were not significantly different between groups (<jats:italic>p<\/jats:italic> for trend = 0.173).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The MHO group had better lung function than other groups. However, longitudinal follow-up studies are required to validate our findings.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0266885","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T17:43:15Z","timestamp":1649871795000},"page":"e0266885","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["The effect of metabolic health and obesity on lung function: A cross sectional study of 114,143 participants from Kangbuk Samsung Health Study"],"prefix":"10.1371","volume":"17","author":[{"given":"Jonghoo","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye 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