{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T06:31:52Z","timestamp":1793082712739,"version":"4.5.0"},"reference-count":76,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T00:00:00Z","timestamp":1649980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Bloodstream infections have been the leading complications in cancer patients because they are at high risk for antibiotic-resistant bacterial infections. There is increasing evidence from different parts of the world of the high prevalence of antimicrobial-resistant bacterial strains in cancer patients. The burden of the infection is high in developing countries, especially in Ethiopia. Data on bacterial profile and antimicrobial susceptibility patterns among cancer patients in Ethiopia is limited. Thus, this study aimed to determine the predominant bacterial species causing bacteremia and their antibiotic resistance pattern among cancer patients at University of Gondar comprehensive specialized hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A hospital-based, cross-sectional study was conducted on 200 study participants from March to July 2021. All cancer patients who developed a fever at the time of hospital visit were included in this study, and their socio-demographic and clinical data were collected using a structured questionnaire. Blood samples (10 mL for adults and 4 mL for children) were collected from each patient, and the collected blood samples were transferred into sterile tryptic soy broth, then incubated at 37\u00b0C for 7 days. Tryptic soy broth which showed signs of growth were Gram-stained and sub-cultured on blood agar, chocolate agar, MacConkey agar, and mannitol salt agar. The inoculated plates were then aerobically incubated at 37\u00b0C for 18\u201324 hours and the isolates obtained were identified using standard microbiological methods. Antimicrobial susceptibility tests were done using a modified Kirby-Bauer disk diffusion technique following CLSI 2021 guidelines. Data were entered using EPI data version 4.6 and analyzed with SPSS version 20.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In this study, out of 200 cancer patients included and 67.5% (135\/200) of them were males. The majorities of study participants, 56% (113\/200) of cancer patients were pediatrics and 26.5% (53\/200) of them belong under five years of age. Out of 200 patient samples that had undergone culture, 27% (54\/200) samples had bacterial growth. Gram-positive bacterial isolates were predominant, 61.1%, and\n                      <jats:italic>S<\/jats:italic>\n                      .\n                      <jats:italic>aureus<\/jats:italic>\n                      was the predominant Gram-positive isolate, (51.5.6%), followed by coagulase-negative staphylococci (48.5%). Moreover,\n                      <jats:italic>K<\/jats:italic>\n                      .\n                      <jats:italic>pneumoniae<\/jats:italic>\n                      (47%) and\n                      <jats:italic>P<\/jats:italic>\n                      .\n                      <jats:italic>aeruginosa<\/jats:italic>\n                      (29.5%) were the most common Gram-negative bacterial isolates. Among patients who had BSIs, the highest prevalence of BSIs was observed among males (66.7%), and in pediatrics cancer patients (44.2%). Pediatric study participants were more venerable to bloodstream infection (P = 0.000) compared to adult participants. Meropenem (100%), amikacin (100%), piperacillin\/tazobactam (72.3%), and ceftazidime (73.5%) were effective against for Gram-negative isolates while cefoxitin (81.2%) and penicillin (70.5%) were effective for Gram-positive isolates. Additionally, most Gram-negative and Gram-positive bacterial isolates were sensitive for gentamycin (75.9%). Multidrug resistance was seen among 17.1% bacterial isolates, and MDR in Gram-negative and Gram-positive bacteria were 83.3% and 16.7%, respectively. Gram-negative bacterial isolates showed a high prevalence of MDR than Gram-positive isolates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions and recommendation<\/jats:title>\n                    <jats:p>\n                      BSI\u2019s remains an important health problem in cancer patients, and Gram-positive bacteria were more common as etiologic agents of BSIs in cancer patients.\n                      <jats:italic>S<\/jats:italic>\n                      .\n                      <jats:italic>aureus<\/jats:italic>\n                      was the dominant bacteria followed by CoNS,\n                      <jats:italic>K<\/jats:italic>\n                      .\n                      <jats:italic>pneumoniae<\/jats:italic>\n                      , and\n                      <jats:italic>P<\/jats:italic>\n                      .\n                      <jats:italic>aeruginosa<\/jats:italic>\n                      . Multidrug-resistant isolates found in cancer patients and routine bacterial surveillance and study of their resistance patterns may guide successful antimicrobial therapy and improve the quality of care. Therefore, strict regulation of antibiotic stewardship and infection control programs should be considered in the study area.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0266919","type":"journal-article","created":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T13:29:13Z","timestamp":1650029353000},"page":"e0266919","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":41,"title":["Bacterial profile and antimicrobial susceptibility patterns in cancer patients"],"prefix":"10.1371","volume":"17","author":[{"given":"Minichil","family":"Worku","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gizeaddis","family":"Belay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4160-1094","authenticated-orcid":true,"given":"Abiye","family":"Tigabu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,4,15]]},"reference":[{"issue":"1","key":"pone.0266919.ref001","first-page":"1","article-title":"Cumulative antimicrobial susceptibility data for a tertiary-level paediatric oncology unit in Johannesburg, South Africa","volume":"3","author":"N Von Knorring","year":"2019","journal-title":"SA Journal of Oncology"},{"issue":"4","key":"pone.0266919.ref002","doi-asserted-by":"crossref","first-page":"341","DOI":"10.4103\/0255-0857.55454","article-title":"Characterization and anti-microbial susceptibility of gram-negative bacteria isolated from bloodstream infections of cancer patients on chemotherapy in Pakistan","volume":"27","author":"S Saghir","year":"2009","journal-title":"Indian journal of medical microbiology"},{"issue":"3","key":"pone.0266919.ref003","doi-asserted-by":"crossref","first-page":"190","DOI":"10.14715\/cmb\/2021.67.3.30","article-title":"Microbiological profile and antibiotic vulnerability of bacterial isolates from cancer patients","volume":"67","author":"S. 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