{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T21:57:26Z","timestamp":1779919046524,"version":"3.53.1"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:00:00Z","timestamp":1659052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11972065"],"award-info":[{"award-number":["11972065"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Beijing Natural Science Foundation","award":["L202006"],"award-info":[{"award-number":["L202006"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Few studies have analyzed the different biomechanical properties of the lumbar with various morphological parameters, which play an important role in injury and degeneration. This study aims to preliminarily investigate biomechanical characteristics of the spine with different sagittal alignment morphotypes by using finite element (FE) simulation and in-vitro testing.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>According to the lumbar-pelvic radiographic parameters of the Chinese population, the parametric FE models (L1-S1-pelvis) of Roussouly\u2019s type (1\u20134) were validated and developed based on the in-vitro biomechanical testing. A pure moment of 7.5 Nm was applied in the three anatomical planes to simulate the physiological activities of flexion, extension, left-right lateral bending and left-right axial rotation.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The sagittal configuration of four Roussouly\u2019s type models had a strong effect on the biomechanical responses in flexion and extension. The apex of the lumbar lordosis is a critical position where the segment has the lowest range of motion among all the models. In flexion-extension, type 3 and 4 models with a good lordosis shape had a more uniform rotation distribution at each motor function segment, however, type 1 and 2 models with a straighter spine had a larger proportion of rotation at the L5-S1 level. In addition, type 1 and 2 models had higher intradiscal pressures (IDPs) at the L4-5 segment in flexion, while type 4 model had larger matrix and fiber stresses at the L5-S1 segment in extension.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The well-marched lordotic type 3 lumbar had greater stability, however, a straighter spine (type 1 and 2) had poor balance and load-bearing capacity. The hypolordotic type 4 model showed larger annulus fiber stress. Therefore, the sagittal alignment of Roussouly\u2019s type models had different kinetic and biomechanical responses under various loading conditions, leading to different clinical manifestations of the lumbar disease.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0266954","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T17:25:09Z","timestamp":1659115509000},"page":"e0266954","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Biomechanical responses of human lumbar spine and pelvis according to the Roussouly 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of sagittal balance on spinal lumbar loads: A numerical approach","volume":"28","author":"F Galbusera","year":"2013","journal-title":"Clin Biomech"},{"key":"pone.0266954.ref002","article-title":"Human balance, the evolution of bipedalism and dysequilibrium syndrome","author":"JR Skoyles","year":"2006","journal-title":"Med Hypotheses"},{"key":"pone.0266954.ref003","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/BF02368136","article-title":"A Barycentremetic Study of the Sagittal Shape of Spine and Pelvis: The Conditions Required for an Economic Standing Position","volume":"20","author":"R Poincar","year":"1992","journal-title":"Ann Biomed Eng"},{"issue":"Suppl 5","key":"pone.0266954.ref004","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s00586-011-1928-x","article-title":"Biomechanical analysis of the spino-pelvic organization and adaptation in pathology","volume":"20","author":"P Roussouly","year":"2011","journal-title":"Eur Spine 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Sebaaly","year":"2020","journal-title":"Eur Spine J"},{"key":"pone.0266954.ref011","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1007\/s43390-020-00112-6","article-title":"Surgical correction of Adult Spinal Deformity in accordance to the Roussouly classification: effect on postoperative mechanical complications","volume":"8","author":"TJ Bari","year":"2020","journal-title":"Spine Deform"},{"key":"pone.0266954.ref012","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00264-014-2516-6","article-title":"Evidence showing the relationship between sagittal balance and clinical outcomes in surgical treatment of degenerative spinal diseases: a literature review","volume":"39","author":"JC Le Huec","year":"2015","journal-title":"Int Orthop"},{"key":"pone.0266954.ref013","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/jor.22569","article-title":"Numerical evaluation of the correlation between the normal variation in the sagittal alignment of the lumbar 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New explicit solution for static shape control of smart laminated cantilever piezo-composite-hybrid plates\/beams under thermo-electro-mechanical loads using piezoelectric actuators","author":"Soheil Gohari","year":"2016","journal-title":"Compos Struct"},{"key":"pone.0266954.ref026","article-title":"A FEM-based model to study the behavior of SRG-strengthened R\/C beams","author":"AA Katsamakas","year":"2021","journal-title":"Compos Struct"},{"key":"pone.0266954.ref027","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1080\/10255842.2020.1745783","article-title":"Sensitivities of lumbar segmental kinematics and functional tissue loads in sagittal bending to design parameters of a ball-in-socket total disc arthroplasty prosthesis","volume":"23","author":"C Zhou","year":"2020","journal-title":"Comput Methods Biomech Biomed Engin"},{"key":"pone.0266954.ref028","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.acme.2019.06.009","article-title":"Localized failure analysis of internally pressurized laminated ellipsoidal woven GFRP composite domes: Analytical, numerical, and experimental studies","volume":"19","author":"S Gohari","year":"2019","journal-title":"Arch Civ Mech Eng"},{"key":"pone.0266954.ref029","article-title":"Comparison of animals used in disc research to human lumbar disc geometry","author":"GD O\u2019Connell","year":"2007","journal-title":"Spine (Phila Pa 1976)"},{"key":"pone.0266954.ref030","article-title":"Geometry of the vertebral bodies and the intervertebral discs in lumbar segments adjacent to spondylolysis and spondylolisthesis: Pilot study","author":"E Been","year":"2011","journal-title":"Eur Spine J"},{"key":"pone.0266954.ref031","article-title":"Proximal junctional kyphosis in adult scoliosis: comparison of four radiological predictor models","author":"A Sebaaly","year":"2018","journal-title":"Eur Spine J"},{"key":"pone.0266954.ref032","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.1007\/s00586-015-4048-1","article-title":"Analysis of an unexplored group of sagittal deformity patients: low pelvic tilt despite positive sagittal malalignment","volume":"25","author":"E Ferrero","year":"2016","journal-title":"Eur Spine J"},{"key":"pone.0266954.ref033","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1097\/01.brs.0000231761.73859.2c","article-title":"What is intervertebral disc degeneration, and what causes it?","author":"MA Adams","year":"2006","journal-title":"Spine"},{"key":"pone.0266954.ref034","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1007\/s00586-006-0294-6","article-title":"Sagittal balance of the pelvis-spine complex and lumbar degenerative diseases. 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