{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:38:03Z","timestamp":1790807883107,"version":"4.1.0"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["MVP000 and CIPHER"],"award-info":[{"award-number":["MVP000 and CIPHER"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR002240"],"award-info":[{"award-number":["UL1TR002240"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["U01TR003528"],"award-info":[{"award-number":["U01TR003528"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000092","name":"U.S. National Library of Medicine","doi-asserted-by":"publisher","award":["1R01LM013337"],"award-info":[{"award-number":["1R01LM013337"]}],"id":[{"id":"10.13039\/100000092","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR001857"],"award-info":[{"award-number":["UL1 TR001857"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1-TR001878"],"award-info":[{"award-number":["UL1-TR001878"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["CTSA Award #UL1TR002366"],"award-info":[{"award-number":["CTSA Award #UL1TR002366"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR001881"],"award-info":[{"award-number":["UL1TR001881"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000092","name":"U.S. National Library of Medicine","doi-asserted-by":"publisher","award":["R01LM012095"],"award-info":[{"award-number":["R01LM012095"]}],"id":[{"id":"10.13039\/100000092","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR001857"],"award-info":[{"award-number":["UL1TR001857"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR002541, UL1TR000005"],"award-info":[{"award-number":["UL1TR002541, UL1TR000005"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000092","name":"U.S. National Library of Medicine","doi-asserted-by":"publisher","award":["R01LM013345"],"award-info":[{"award-number":["R01LM013345"]}],"id":[{"id":"10.13039\/100000092","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["3U01HG008685-05S2"],"award-info":[{"award-number":["3U01HG008685-05S2"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS098023"],"award-info":[{"award-number":["R01NS098023"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>In young adults (18 to 49 years old), investigation of the acute respiratory distress syndrome (ARDS) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been limited. We evaluated the risk factors and outcomes of ARDS following infection with SARS-CoV-2 in a young adult population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study was conducted between January 1st, 2020 and February 28th, 2021 using patient-level electronic health records (EHR), across 241 United States hospitals and 43 European hospitals participating in the Consortium for Clinical Characterization of COVID-19 by EHR (4CE). To identify the risk factors associated with ARDS, we compared young patients with and without ARDS through a federated analysis. We further compared the outcomes between young and old patients with ARDS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 75,377 hospitalized patients with positive SARS-CoV-2 PCR, 1001 young adults presented with ARDS (7.8% of young hospitalized adults). Their mortality rate at 90 days was 16.2% and they presented with a similar complication rate for infection than older adults with ARDS. Peptic ulcer disease, paralysis, obesity, congestive heart failure, valvular disease, diabetes, chronic pulmonary disease and liver disease were associated with a higher risk of ARDS. We described a high prevalence of obesity (53%), hypertension (38%- although not significantly associated with ARDS), and diabetes (32%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Trough an innovative method, a large international cohort study of young adults developing ARDS after SARS-CoV-2 infection has been gather. It demonstrated the poor outcomes of this population and associated risk factor.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0266985","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T13:22:52Z","timestamp":1672838572000},"page":"e0266985","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Acute respiratory distress syndrome after SARS-CoV-2 infection on young adult population: International observational federated study based on electronic health records through the 4CE consortium"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9197-721X","authenticated-orcid":true,"given":"Bertrand","family":"Moal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5680-8701","authenticated-orcid":true,"given":"Arthur","family":"Orieux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Fert\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Neuraz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel A.","family":"Brat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0235-7543","authenticated-orcid":true,"given":"Paul","family":"Avillach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara-Lea","family":"Bonzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxi","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Cossin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1096-137X","authenticated-orcid":true,"given":"Romain","family":"Griffier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6931-3791","authenticated-orcid":true,"given":"David A.","family":"Hanauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8165-4783","authenticated-orcid":true,"given":"Christian","family":"Haverkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuk-Lam","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan R.","family":"Hutch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2043-1601","authenticated-orcid":true,"given":"Jeffrey G.","family":"Klann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3737-6565","authenticated-orcid":true,"given":"Trang T.","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ne Hooi Will","family":"Loh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeline","family":"Makoudjou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle L.","family":"Mowery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L.","family":"Olson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lav P.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malarkodi J.","family":"Samayamuthu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7165-0949","authenticated-orcid":true,"given":"Fernando J.","family":"Sanz Vidorreta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily R.","family":"Schriver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6135-0173","authenticated-orcid":true,"given":"Petra","family":"Schubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Verdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2079-8684","authenticated-orcid":true,"given":"Shyam","family":"Visweswaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Griffin M.","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongqi","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harrison G.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9929-7403","authenticated-orcid":true,"given":"Daniela","family":"Z\u00f6ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac S.","family":"Kohane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The Consortium for Clinical Characterization of COVID-19 by EHR (4CE)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Boyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5272-2265","authenticated-orcid":true,"given":"Vianney","family":"Jouhet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,1,4]]},"reference":[{"key":"pone.0266985.ref001","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1164\/ajrccm.149.3.7509706","article-title":"The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination","volume":"149","author":"GR Bernard","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"key":"pone.0266985.ref002","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1056\/NEJMoa2002032","article-title":"Clinical Characteristics of Coronavirus Disease 2019 in China","volume":"382","author":"W Guan","year":"2020","journal-title":"N Engl J Med"},{"key":"pone.0266985.ref003","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1016\/S0140-6736(20)31189-2","article-title":"Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study","volume":"395","author":"MJ Cummings","year":"2020","journal-title":"The Lancet"},{"key":"pone.0266985.ref004","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1177\/0885066620946692","article-title":"COVID-19-Associated Critical Illness\u2014Report of the First 300 Patients Admitted to Intensive Care Units at a New York City Medical Center","volume":"35","author":"S Chand","year":"2020","journal-title":"J Intensive Care Med"},{"key":"pone.0266985.ref005","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1007\/s42399-020-00476-w","article-title":"Age-Adjusted Risk Factors Associated with Mortality and Mechanical Ventilation Utilization Amongst COVID-19 Hospitalizations\u2014a Systematic Review and Meta-Analysis","volume":"2","author":"U Patel","year":"2020","journal-title":"SN Compr Clin Med"},{"key":"pone.0266985.ref006","unstructured":"Luyt C-E. Long-term Outcomes of Pandemic 2009 Influenza A(H1N1)-Associated Severe ARDS.: 10."},{"key":"pone.0266985.ref007","volume":"22","author":"MA Matthay","year":"2019","journal-title":"Acute respiratory distress syndrome"},{"key":"pone.0266985.ref008","doi-asserted-by":"crossref","first-page":"689","DOI":"10.4187\/respcare.04644","article-title":"What\u2019s Next After ARDS: Long-Term Outcomes","volume":"61","author":"D Chiumello","year":"2016","journal-title":"Respir Care"},{"key":"pone.0266985.ref009","article-title":"Acute Management and Long-Term Survival Among Subjects With Severe Middle East Respiratory Syndrome Coronavirus Pneumonia and ARDS","volume":"9","author":"I Khalid","year":"2015","journal-title":"Respir CARE"},{"key":"pone.0266985.ref010","first-page":"6","article-title":"Long-term outcome after the acute respiratory distress syndrome: different from general critical illness?","volume":"23","author":"T Bein","year":"2017","journal-title":"Respir Syst"},{"key":"pone.0266985.ref011","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ccc.2011.10.004","article-title":"Economics of Mechanical Ventilation and Respiratory Failure","volume":"28","author":"CR Cooke","year":"2012","journal-title":"Crit Care Clin"},{"key":"pone.0266985.ref012","article-title":"Characteristics of Adults aged 18\u201349 Years without Underlying Conditions Hospitalized with Laboratory-Confirmed COVID-19 in the United States, COVID-NET\u2014March\u2013August 2020","author":"D Owusu","year":"2020","journal-title":"Clin Infect Dis"},{"key":"pone.0266985.ref013","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1001\/jamainternmed.2020.5313","article-title":"Clinical Outcomes in Young US Adults Hospitalized With COVID-19","volume":"181","author":"JW Cunningham","year":"2021","journal-title":"JAMA Intern Med"},{"key":"pone.0266985.ref014","article-title":"Risk factors for severity of COVID-19 in hospital patients age 18\u201329 years","volume":"22","author":"M Sandoval","journal-title":"PLOS ONE"},{"key":"pone.0266985.ref015","doi-asserted-by":"crossref","first-page":"e0243343","DOI":"10.1371\/journal.pone.0243343","article-title":"Characteristics, comorbidities and survival analysis of young adults hospitalized with COVID-19 in New York City","volume":"15","author":"BL Altonen","year":"2020","journal-title":"PLOS ONE"},{"key":"pone.0266985.ref016","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/s41746-020-00308-0","article-title":"International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium","volume":"3","author":"GA Brat","year":"2020","journal-title":"Npj Digit Med"},{"key":"pone.0266985.ref017","article-title":"Validation of a Derived International Patient Severity Algorithm to Support COVID-19 Analytics from Electronic Health Record Data","author":"JG Klann","year":"2020","journal-title":"Health Informatics"},{"key":"pone.0266985.ref018","doi-asserted-by":"crossref","first-page":"700656","DOI":"10.3389\/fped.2021.700656","article-title":"National Trends in Disease Activity for COVID-19 Among Children in the US","volume":"9","author":"Consortium for Clinical Characterization of COVID-19 by EHR (4CE)","year":"2021","journal-title":"Front Pediatr"},{"key":"pone.0266985.ref019","doi-asserted-by":"crossref","first-page":"e2112596","DOI":"10.1001\/jamanetworkopen.2021.12596","article-title":"International Analysis of Electronic Health Records of Children and Youth Hospitalized With COVID-19 Infection in 6 Countries","volume":"4","author":"FT Bourgeois","year":"2021","journal-title":"JAMA Netw Open"},{"key":"pone.0266985.ref020","unstructured":"International Comparisons of Harmonized Laboratory Value Trajectories to Predict Severe COVID-19: Leveraging the 4CE Collaborative Across 342 Hospitals and 6 Countries: A Retrospective Cohort Study | medRxiv. [cited 22 Dec 2020]. https:\/\/www.medrxiv.org\/content\/10.1101\/2020.12.16.20247684v1"},{"key":"pone.0266985.ref021","article-title":"What Every Reader Should Know About Studies Using Electronic Health Record Data but May Be Afraid to Ask","volume":"9","author":"IS Kohane","journal-title":"J Med INTERNET Res."},{"key":"pone.0266985.ref022","unstructured":"WHO Anatomical Therapeutic Chemical (ATC) Classification. https:\/\/pubchem.ncbi.nlm.nih.gov\/source\/11950"},{"key":"pone.0266985.ref023","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00005650-199801000-00004","article-title":"Comorbidity Measures for Use with Administrative Data","volume":"36","author":"A Elixhauser","year":"1998","journal-title":"Med Care"},{"key":"pone.0266985.ref024","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v036.i03","article-title":"Conducting Meta-Analyses in R with the metafor Package","volume":"36","author":"W. Viechtbauer","year":"2010","journal-title":"J Stat Softw"},{"key":"pone.0266985.ref025","article-title":"Incidence and Outcomes of Acute Lung Injury","volume":"9","author":"GD Rubenfeld","year":"2005","journal-title":"N Engl J Med"},{"key":"pone.0266985.ref026","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1001\/jama.2016.0291","article-title":"Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries","volume":"315","author":"G Bellani","year":"2016","journal-title":"JAMA"},{"key":"pone.0266985.ref027","doi-asserted-by":"crossref","first-page":"e193215","DOI":"10.1001\/jamanetworkopen.2019.3215","article-title":"Association of Age With Short-term and Long-term Mortality Among Patients Discharged From Intensive Care Units in France","volume":"2","author":"A Atramont","year":"2019","journal-title":"JAMA Netw Open"},{"key":"pone.0266985.ref028","doi-asserted-by":"crossref","first-page":"42","DOI":"10.14740\/jocmr3660","article-title":"Gastrointestinal Bleeding in Patients With Acute Respiratory Distress Syndrome: A National Database Analysis","volume":"11","author":"F Siddiqui","year":"2019","journal-title":"J Clin Med Res"},{"key":"pone.0266985.ref029","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/s00134-015-3725-1","article-title":"Prevalence and outcome of gastrointestinal bleeding and use of acid suppressants in acutely ill adult intensive care patients","volume":"41","author":"the SUP-ICU co-authors","year":"2015","journal-title":"Intensive Care Med"},{"key":"pone.0266985.ref030","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1378\/chest.12-0117","article-title":"Obesity and ARDS","volume":"142","author":"K Hibbert","year":"2012","journal-title":"Chest"},{"key":"pone.0266985.ref031","article-title":"Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study","author":"CM Petrilli","year":"2020","journal-title":"BMJ"},{"key":"pone.0266985.ref032","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1097\/CCM.0b013e3181a0fea5","article-title":"Diabetes, insulin, and development of acute lung injury","volume":"37","author":"S Honiden","year":"2009","journal-title":"Crit Care Med"},{"key":"pone.0266985.ref033","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1097\/00003246-200007000-00001","article-title":"Diabetic patients have a decreased incidence of acute respiratory distress syndrome","volume":"28","author":"M Moss","year":"2000","journal-title":"Crit Care Med"},{"key":"pone.0266985.ref034","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/s13054-018-2158-y","article-title":"Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database","volume":"22","author":"on behalf of the LUNG SAFE Investigators","year":"2018","journal-title":"Crit Care"},{"key":"pone.0266985.ref035","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1007\/s12325-018-0805-y","article-title":"Interpretation and Impact of Real-World Clinical Data for the Practicing Clinician","volume":"35","author":"L Blonde","year":"2018","journal-title":"Adv Ther"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0266985","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T13:23:18Z","timestamp":1672838598000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0266985"}},"subtitle":[],"editor":[{"given":"Robert Jeenchen","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,1,4]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0266985","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.03.31.22273257","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,4]]}}}