{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:55:45Z","timestamp":1791053745463,"version":"4.1.0"},"reference-count":75,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T00:00:00Z","timestamp":1652227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hindustan Unilever Limited","award":["212332"],"award-info":[{"award-number":["212332"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Introduction<\/jats:title>\n<jats:p>Childhood and adolescence require adequate amount of micronutrients for normal growth and development. The primary objective of study was to assess the prevalence of deficiencies of Vitamins (Vitamin A, 25 Hydroxy Vitamin D, Vitamin B12 and Folate) and minerals (Calcium, Zinc, Selenium and Iron), among urban school going children aged 6\u201311 and 12\u201316 years in ten cities of India. Secondary objective was to find the association between micronutrient deficiencies with sociodemographic and anthropometric indicators.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>A multi-center cross-sectional study was conducted across India. Participants in the age groups of 6 to 11 years (group 1) and 12 to 16 years (group 2) were selected from randomly chosen schools from each center. Data on socio economic status, anthropometric measures was collected. Blood samples were collected for biochemical analysis of micronutrients. Point estimates and 95% confidence intervals was used to assess the prevalence of deficiencies. Associations were observed using chi square, student t test and ANOVA test.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>From April 2019 to February 2020, 2428 participants (1235 in group 1 and 1193 group 2) were recruited from 60 schools across ten cites. The prevalence of calcium and iron deficiency was 59.9% and 49.4% respectively. 25 Hydroxy Vitamin D deficiency was seen in 39.7% and vitamin B12 in 33.4% of subjects. Folate, Selenium and Zinc were deficient in 22.2%, 10.4% and 6.8% of subjects respectively. Vitamin A deficiency least (1.6%). Anemia was prevalent in 17.6% subjects and was more common among females.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>One or more micronutrient deficiencies are found in almost one half of school going children in urban area. Hence efforts must be made to combat these on priority.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Trial registration number<\/jats:title>\n<jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ctri.nic.in\/Clinicaltrials\/pdf_generate.php?trialid=31533&amp;EncHid=&amp;modid=&amp;compid=%27,CTRI\/2019\/02\/017783\" xlink:type=\"simple\">CTRI\/2019\/02\/017783<\/jats:ext-link>.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0267003","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T18:20:08Z","timestamp":1652293208000},"page":"e0267003","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":43,"title":["Prevalence of specific micronutrient deficiencies in urban school going children and adolescence of India: A multicenter cross-sectional study"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1254-9802","authenticated-orcid":true,"given":"Shally","family":"Awasthi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divas","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas Ali","family":"Mahdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girdhar G.","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuj Kumar","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hina","family":"Parveen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Awasthi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsh","family":"Pande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anish","family":"T. 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Black","year":"2003","journal-title":"Journal of Nutrition"},{"key":"pone.0267003.ref003","first-page":"99","article-title":"Assessment of mental and motor abilities of school going children with anaemia","volume":"42","author":"A.R. Gowri","year":"2005","journal-title":"Indian Journal of Nutrition and Dietetics"},{"issue":"1","key":"pone.0267003.ref004","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1089\/acm.2000.6.19","article-title":"The effect of vitamin-mineral supplementation on the intelligence of American schoolchildren: a randomized, double-blind placebo-controlled trial","volume":"6","author":"S. J. Schoenthaler","year":"2000","journal-title":"J Altern Complement Med"},{"key":"pone.0267003.ref005","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.2147\/NDT.S72491","article-title":"Iron deficiency and cognitive functions","volume":"10","author":"I. 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Lozoff","year":"2006","journal-title":"Semin Pediatr Neurol"},{"issue":"4","key":"pone.0267003.ref009","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.clnu.2016.06.013","article-title":"Feeding the brain\u2013The effects of micronutrient interventions on cognitive performance among school-aged children: A systematic review of randomized controlled trials","volume":"36","author":"Tanya R. Lawlis Long Fung Lam","year":"2017","journal-title":"Clinical Nutrition"},{"key":"pone.0267003.ref010","author":"B Thompson","year":"2014"},{"key":"pone.0267003.ref011","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1016\/S0140-6736(17)32804-0","article-title":"Nations within a nation: Variations in epidemiological transition across the states of India, 1990\u20132016 in the Global Burden of Disease Study","volume":"390","author":"India State-Level Disease Burden Initiative Collaborators","year":"2017","journal-title":"Lancet"},{"key":"pone.0267003.ref012","unstructured":"National Family Health Survey (NFHS-4), 2015\u201316. Mumbai: IIPS; [accessed on January 10, 2022]. International Institute for Population Sciences. Available from: http:\/\/rchiips.org\/nfhs\/NFHS4Reports\/India.pdf."},{"key":"pone.0267003.ref013","unstructured":"Prevalence of micronutrient deficiencies. New Delhi: Indian Council of Medical Research; 2003. [accessed on January 10, 2022]. National Nutrition Monitoring Bureau. NNMB Technical report No: 22. Available from: http:\/\/www.nnmbindia.org\/NNMB%20MND%20REPORT%202004-web.pdf."},{"key":"pone.0267003.ref014","unstructured":"Coverage evaluation Survey 2009, AHS, DLHS, NFHS\u2014Open Government Data (OGD) Platform India accessed January 10, 2022."},{"key":"pone.0267003.ref015","unstructured":"District Level Household and Facility Survey (DLHS-4) Mumbai: IIPS; 2012\u201313. [accessed on August 2, 2018]. International Institute for Population Sciences. Available from: http:\/\/www.rchiips.org\/DLHS-4.html"},{"key":"pone.0267003.ref016","unstructured":"District Level Household and Facility Survey (DLHS-4) Mumbai: IIPS; 2012\u201313. [accessed on January 10, 2022]. International Institute for Population Sciences. Available from: http:\/\/www.rchiips.org\/DLHS-4.html"},{"issue":"5","key":"pone.0267003.ref017","doi-asserted-by":"crossref","first-page":"511","DOI":"10.4103\/ijmr.IJMR_1768_18","article-title":"Micronutrient status of Indian population","volume":"148","author":"Z Gonmei","year":"2018","journal-title":"Indian J Med Res"},{"key":"pone.0267003.ref018","unstructured":"Ministry of Health and Family Welfare (MoHFW), Government of India, UNICEF and Population Council. 2019. Comprehensive National Nutrition Survey (CNNS) National Report. New Delhi."},{"issue":"9","key":"pone.0267003.ref019","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s13312-010-0116-0","article-title":"Impact of two regimens of Vitamin D supplementation on calcium\u2014Vitamin D\u2013PTH axis of schoolgirls of Delhi","volume":"47","author":"RK Marwaha","year":"2010","journal-title":"Indian Pediatr"},{"issue":"5","key":"pone.0267003.ref020","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1111\/j.1365-2265.2008.03360.x","article-title":"VDD in rural girls and pregnant women despite abundant sunshine in northern India","volume":"70","author":"M Sahu","year":"2009","journal-title":"Clin Endocrinol (Oxf)"},{"key":"pone.0267003.ref021","doi-asserted-by":"crossref","first-page":"178","DOI":"10.4103\/2230-8210.196031","article-title":"Prevalence of Vitamin D deficiency and associated risk factors among children residing at high altitude in Shimla district, Himachal Pradesh, India.","volume":"21","author":"U 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Wu","year":"2006","edition":"4"},{"key":"pone.0267003.ref039","volume-title":"Clinical Chemistry: Theory Analysis.","author":"W.E. Schreiber","year":"2010","edition":"5"},{"key":"pone.0267003.ref040","author":"World Health Organization"},{"key":"pone.0267003.ref041","volume-title":"Vitamin and Mineral Nutrition Information System","author":"World Health Organization","year":"2011"},{"key":"pone.0267003.ref042","volume-title":"Tietz Textbook of Clinical Chemistry","author":"A. Burtis","year":"1999","edition":"3"},{"key":"pone.0267003.ref043","volume-title":"Effects of disease on Clinical Lab","author":"DS Young","year":"2001","edition":"4"},{"key":"pone.0267003.ref044","author":"K.L. Nutall","year":"2001","edition":"5"},{"key":"pone.0267003.ref045","volume-title":"Clinical Chemistry: Theory, Analysis, Correlation","author":"W.E. Schreiber","year":"2003","edition":"4"},{"key":"pone.0267003.ref046","first-page":"2302","author":"Burtis Carl","edition":"4"},{"issue":"2","key":"pone.0267003.ref047","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1093\/ajcn\/nqab066","article-title":"Prevalence of low serum zinc concentrations in Indian children and adolescents: findings from the Comprehensive National Nutrition Survey 2016\u201318","volume":"114","author":"R Pullakhandam","year":"2021","journal-title":"Am J Clin Nutr"},{"key":"pone.0267003.ref048","volume-title":"Vitamin and Mineral Nutrition Information System","author":"World Health Organization","year":"2011"},{"issue":"9","key":"pone.0267003.ref049","doi-asserted-by":"crossref","first-page":"189","DOI":"10.46234\/ccdcw2021.057","article-title":"Serum Vitamin A Nutritional Status of Children and Adolescents Aged 6\u221217 Years\u2014China, 2016\u22122017[J].","volume":"3","author":"Rui Wang","year":"2021","journal-title":"China CDC Weekly"},{"key":"pone.0267003.ref050","volume-title":"Vitamin and Mineral Nutrition Information System.","year":"2015"},{"issue":"9890","key":"pone.0267003.ref051","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0140-6736(13)60937-X","article-title":"Maternal and child undernutrition and overweight in low-income and middle-income countries","volume":"382","author":"R Black","year":"2013","journal-title":"Lancet"},{"key":"pone.0267003.ref052","doi-asserted-by":"crossref","first-page":"478S","DOI":"10.1093\/ajcn\/nqaa101","article-title":"Intraindividual double burden of overweight and micronutrient deficiencies or anemia among preschool children","volume":"112","author":"Junjie Guo Reina Engle-Stone","year":"2020","journal-title":"The American Journal of Clinical Nutrition"},{"key":"pone.0267003.ref053","volume-title":"Text Book of Human Nutrition","author":"N Pralhad Rao","year":"2009"},{"key":"pone.0267003.ref054","first-page":"257","article-title":"Universal vitamin A supplementation programme in India: the need for a re-look (editorial).","volume":"23","author":"U Kapil","year":"2010","journal-title":"Nat Med J India"},{"key":"pone.0267003.ref055","first-page":"1601","article-title":"National nutrition supplementation programs.","volume":"29","author":"U Kapil","year":"1992","journal-title":"Indian Pediatr"},{"key":"pone.0267003.ref056","doi-asserted-by":"crossref","first-page":"583654","DOI":"10.3389\/fendo.2021.583654","article-title":"Modern India and Dietary Calcium Deficiency\u2014Half a Century Nutrition Data\u2014Retrospect\u2013Introspect and the Road Ahead.","volume":"12","author":"CV Harinarayan","year":"2021","journal-title":"Front. Endocrinol"},{"issue":"2","key":"pone.0267003.ref057","doi-asserted-by":"crossref","first-page":"324","DOI":"10.4103\/jfmpc.jfmpc_78_18","article-title":"Vitamin D deficiency in India.","volume":"7","author":"P Aparna","year":"2018","journal-title":"J Family Med Prim Care"},{"key":"pone.0267003.ref058","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S0140-6736(15)60865-0","article-title":"Iron deficiency anaemia","volume":"387","author":"A Lopez","year":"2016","journal-title":"Lancet"},{"issue":"11","key":"pone.0267003.ref059","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1080\/17474086.2017.1354696","article-title":"Anemia in children: prevalence, causes, diagnostic work-up, and long-term consequences","volume":"10","author":"Slimane Allali","year":"2017","journal-title":"Expert Review of Hematology"},{"key":"pone.0267003.ref060","author":"A. Sommer","year":"1995","edition":"3"},{"key":"pone.0267003.ref061","doi-asserted-by":"crossref","first-page":"100768","DOI":"10.1016\/j.cegh.2021.100768","article-title":"Prevalence and determinants of Vitamin A deficiency among children in India: Findings from a national cross-sectional survey","volume":"11","author":"Sampurna Kundu","year":"2021","journal-title":"Clinical Epidemiology and Global Health"},{"key":"pone.0267003.ref062","volume-title":"Gazette of India: Notification, Part-2: standards on fortification","author":"National Report. New Delhi. Food Safety and Standards Authority of India (FSSAI)","year":"2018"},{"issue":"7","key":"pone.0267003.ref063","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1039\/c3mt00353a","article-title":"Multiple impacts of zinc on immune function","volume":"6","author":"Hajo Haase","year":"2014","journal-title":"Metallomics"},{"key":"pone.0267003.ref064","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/s41558-018-0253-3","article-title":"Impact of anthropogenic CO2 emissions on global human nutrition","volume":"8","author":"M.R. Smith","year":"2018","journal-title":"Nature Clim Change"},{"key":"pone.0267003.ref065","volume-title":"Selenium Deficiency.","author":"AP Shreenath","year":"2020"},{"key":"pone.0267003.ref066","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.3390\/nu12072098","article-title":"Selenium deficiency is associated with mortality risk from COVID-19.","volume":"12","author":"A Moghaddam","year":"2020","journal-title":"Nutrients"},{"key":"pone.0267003.ref067","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1093\/ajcn\/nqaa095","article-title":"Association between regional selenium status and reported outcome of COVID-19 cases in China","volume":"11","author":"J Zhang","year":"2020","journal-title":"Am J Clin Nutr"},{"key":"pone.0267003.ref068","doi-asserted-by":"crossref","first-page":"111053","DOI":"10.1016\/j.nut.2020.111053","article-title":"An exploratory study of selenium status in healthy individuals and in patients with COVID-19 in a south Indian population: The case for adequate selenium status","volume":"82","author":"M Majeed","year":"2021","journal-title":"Nutrition"},{"key":"pone.0267003.ref069","first-page":"452","article-title":"Association between fatality rate of COVID-19 and selenium deficiency in China.","volume":"21","author":"H Zhang","year":"2021","journal-title":"Infectious Diseases"},{"issue":"5","key":"pone.0267003.ref070","doi-asserted-by":"crossref","first-page":"457","DOI":"10.5223\/pghn.2020.23.5.457","article-title":"Risk Factors and Nutritional Profiles Associated with Stunting in Children","volume":"23","author":"ADB Febriani","year":"2020","journal-title":"Pediatr Gastroenterol Hepatol Nutr"},{"issue":"11","key":"pone.0267003.ref071","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1017\/S1368980017002816","article-title":"Vitamin D status is associated with underweight and stunting in children aged 6\u201336 months residing in the Ecuadorian Andes","volume":"21","author":"R. Mokhtar","year":"2018","journal-title":"Public Health Nutrition"},{"key":"pone.0267003.ref072","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1007\/s00394-018-1876-x","article-title":"The association between serum zinc level and overweight\/obesity: a meta-analysis.","volume":"58","author":"Gu","year":"2019","journal-title":"Eur J Nutr"},{"key":"pone.0267003.ref073","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s12011-020-02060-8","article-title":"Association of Serum Zinc Levels in Overweight and Obesity","author":"M.J. Lugo","year":"2020","journal-title":"Biol Trace Elem Res"},{"key":"pone.0267003.ref074","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s12011-016-0691-6","article-title":"Trace element alterations in the hair of diabetic and obese women","volume":"174","author":"S.H. 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