{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T10:34:15Z","timestamp":1774953255672,"version":"3.50.1"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T00:00:00Z","timestamp":1649980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"grants-in-aid from the research committee of ataxia, health labor sciences research grant, the ministry of health, labor and welfare, japan","award":["JPMH20FC1041"],"award-info":[{"award-number":["JPMH20FC1041"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"\nBackground<\/jats:title>\nThe standardized T1-weighted\/T2-weighted (sT1w\/T2w) ratio for the middle cerebellar peduncle (MCP) has been reported to be sensitive for detecting degenerative changes in the cerebellar subtype of multiple system atrophy (MSA-C), even in the early stages. We aimed to investigate the diagnostic value of the MCP sT1w\/T2w ratio for differentiating between MSA-C and spinocerebellar ataxia (SCA).<\/jats:p>\n<\/jats:sec>\n\nMethods<\/jats:title>\nWe included 32 MSA-C, 8 SCA type 3 (SCA3), 16 SCA type 6 (SCA6) patients, and 17 controls, and the MCP sT1w\/T2w ratio was analyzed using a region-of-interest approach. The diagnostic performance of the MCP sT1w\/T2w ratio in discriminating among MSA-C, SCA3, and SCA6 was assessed and compared with diagnosis based on visual interpretation of MCP hyperintensities and the \u201chot cross bun\u201d (HCB) sign.<\/jats:p>\n<\/jats:sec>\n\nResults<\/jats:title>\nMCP sT1w\/T2w ratio values were markedly lower in patients with MSA-C than in those with SCA3, those with SCA6, and controls (p<\/jats:italic> < 0.001). The MCP sT1w\/T2w ratio showed high diagnostic accuracy for distinguishing MSA-C from SCA3 (area under curve = 0.934), SCA6 (area under curve = 0.965), and controls (area under curve = 0.980). The diagnostic accuracy of the MCP sT1w\/T2w ratio for differentiating MSA-C from SCA3 or SCA6 (90.0% for MSA-C vs. SCA3, and 91.7% for MSA-C vs. SCA6) was comparable to or superior than that of visual interpretation of MCP hyperintensities (80.0\u201387.5% in MSA-C vs. SCA3 and 87.6\u201397.9% in MSA-C vs. SCA6) or the HCB sign (72.5\u201380.0% in MSA-C vs. SCA3 and 77.1\u201393.8% in MSA-C vs. SCA6).<\/jats:p>\n<\/jats:sec>\n\nConclusions<\/jats:title>\nThe MCP sT1w\/T2w ratio might be a sensitive imaging-based marker for detecting MSA-C-related changes and differentiating MSA-C from SCA3 or SCA6.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0267024","type":"journal-article","created":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T17:26:47Z","timestamp":1650043607000},"page":"e0267024","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Diagnostic efficacy of the magnetic resonance T1w\/T2w ratio for the middle cerebellar peduncle in multiple system atrophy and spinocerebellar ataxia: A preliminary study"],"prefix":"10.1371","volume":"17","author":[{"given":"Jiaqi","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuhiko","family":"Sugiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2389-0299","authenticated-orcid":true,"given":"Hajime","family":"Yokota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeki","family":"Hirano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Mukai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Ohira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyosuke","family":"Koide","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoichi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Finke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander U.","family":"Brandt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friedemann","family":"Paul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Kuwabara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2022,4,15]]},"reference":[{"key":"pone.0267024.ref001","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1212\/01.wnl.0000324625.00404.15","article-title":"Second consensus statement on the diagnosis of multiple system atrophy","volume":"71","author":"S Gilman","year":"2008","journal-title":"Neurology"},{"key":"pone.0267024.ref002","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1002\/mds.22413","article-title":"Proposed neuroimaging criteria for the diagnosis of multiple system atrophy","volume":"24","author":"Neuroimaging Working Group on 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