{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:16:42Z","timestamp":1787498202847,"version":"build-2736575974"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T00:00:00Z","timestamp":1649894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To quantitatively analyze morphological and functional alterations of the meibomian glands in eyes with marginal entropion and their changes after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixty eyes of 52 patients with marginal entropion and underwent meibography and interferometer were included. One-hundred and seventeen age- and sex-matched eyes with minimal to mild meibomian gland dysfunction (MGD) were recruited as control eyes. Meibomian gland loss (MGL) and lipid layer thickness (LLT) were compared between eyes with marginal entropion and control eyes. Subgroup analysis was performed according to the extent of entropion. MGL and average LLT at 1 and 5 months after surgery were compared with those of 20 eyes with marginal entropion followed without surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In eyes with marginal entropion, MGL was higher (27.7% vs. 12.8%, P = 0.014), and average LLT was thinner (64 nm vs. 86 nm, P = 0.005) than those in control eyes. MGL was higher in eyes with more extensive entropion (&gt; 2\/3 eyelid width) than in eyes with less extensive entropion (\u2264 1\/3 eyelid width) (40.5% vs. 13.2%, P = 0.001). Average LLT increased after surgery (97 nm at 1 month, P = 0.003; 75 nm at 5 months, P = 0.319), and thicker than that of eyes followed without surgery (97 nm vs. 66 nm, P = 0.046). MGLs after surgery remained unchanged from the preoperative MGL (all P &gt; 0.7).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Marginal entropion is associated with morphological and functional alterations of the meibomian glands. Functional improvement after entropion repair suggests that marginal entropion could cause or exacerbate MGD. Further studies are required to establish the role of entropion repair in managing MGD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0267118","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T13:35:31Z","timestamp":1649943331000},"page":"e0267118","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Quantitative analysis of morphological and functional alterations of the meibomian glands in eyes with marginal entropion"],"prefix":"10.1371","volume":"17","author":[{"given":"Min Kyu","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho-Seok","family":"Sa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4815-0804","authenticated-orcid":true,"given":"Namju","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Sun","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon Young","family":"Hyon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hokyung","family":"Choung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang In","family":"Khwarg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,4,14]]},"reference":[{"key":"pone.0267118.ref001","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/IOP.0000000000000008","article-title":"Correction of lower eyelid marginal entropion by eyelid margin splitting and anterior lamellar repositioning","volume":"30","author":"YJ Choi","year":"2014","journal-title":"Ophthalmic Plast Reconstr Surg"},{"key":"pone.0267118.ref002","doi-asserted-by":"crossref","first-page":"203","DOI":"10.4274\/tjo.20591","article-title":"Marginal Entropion: A Frequently Overlooked Eyelid Malposition","volume":"45","author":"M Erdogan","year":"2015","journal-title":"Turk J Ophthalmol"},{"key":"pone.0267118.ref003","first-page":"99","volume-title":"Techniques in ophthalmic plastic surgery","author":"JA Nerad","year":"2010"},{"key":"pone.0267118.ref004","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/S0161-6420(93)31485-5","article-title":"The histopathology and the mechanism of entropion in patients with trachoma","volume":"100","author":"AA al-Rajhi","year":"1993","journal-title":"Ophthalmology"},{"key":"pone.0267118.ref005","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.ajo.2005.11.004","article-title":"Marx line: fluorescein staining line on the inner lid as indicator of meibomian gland function","volume":"141","author":"M Yamaguchi","year":"2006","journal-title":"Am J Ophthalmol"},{"key":"pone.0267118.ref006","doi-asserted-by":"crossref","first-page":"5","DOI":"10.17816\/OV915-12","article-title":"Meibomian gland dysfunction with involutional eyelids malposition","volume":"9","author":"RV Potemkin VV","year":"2016","journal-title":"Ophthalmology journal"},{"key":"pone.0267118.ref007","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3928\/1542-8877-19970201-14","article-title":"Tarsoconjunctival advancement: a modified surgical technique to correct cicatricial entropion and metaplasia of the marginal tarsus","volume":"28","author":"R Kuckelkorn","year":"1997","journal-title":"Ophthalmic Surg Lasers"},{"key":"pone.0267118.ref008","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.ajo.2013.01.008","article-title":"Correlation between quantitative measurements of tear film lipid layer thickness and meibomian gland loss in patients with obstructive meibomian gland dysfunction and normal controls","volume":"155","author":"Y Eom","year":"2013","journal-title":"Am J Ophthalmol"},{"key":"pone.0267118.ref009","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.ophtha.2007.06.031","article-title":"Noncontact infrared meibography to document age-related changes of the meibomian glands in a normal population","volume":"115","author":"R Arita","year":"2008","journal-title":"Ophthalmology"},{"key":"pone.0267118.ref010","first-page":"231","article-title":"Assessment of the Tear Film Lipid Layer Thickness after Cataract Surgery","volume":"33","author":"JS Kim","year":"2018","journal-title":"Semin Ophthalmol"},{"key":"pone.0267118.ref011","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ophtha.2008.10.012","article-title":"Contact lens wear is associated with decrease of meibomian glands","volume":"116","author":"R Arita","year":"2009","journal-title":"Ophthalmology"},{"key":"pone.0267118.ref012","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s00417-012-1943-6","article-title":"Effects of long-term topical anti-glaucoma medications on meibomian glands","volume":"250","author":"R Arita","year":"2012","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"pone.0267118.ref013","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.jcjo.2017.11.006","article-title":"Functional and structural evaluation of the meibomian gland using a LipiView interferometer in thyroid eye disease","volume":"53","author":"J Park","year":"2018","journal-title":"Can J Ophthalmol"},{"key":"pone.0267118.ref014","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.ophtha.2012.06.064","article-title":"Improving awareness, identification, and management of meibomian gland dysfunction","volume":"119","author":"GN Foulks","year":"2012","journal-title":"Ophthalmology"},{"key":"pone.0267118.ref015","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1097\/ICO.0b013e318191b870","article-title":"The relationship between dry eye symptoms and lipid layer thickness","volume":"28","author":"CA Blackie","year":"2009","journal-title":"Cornea"},{"key":"pone.0267118.ref016","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.clae.2011.08.003","article-title":"Non-contact meibography: keep it simple but effective","volume":"35","author":"H Pult","year":"2012","journal-title":"Cont Lens Anterior Eye"},{"key":"pone.0267118.ref017","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1097\/ICO.0b013e3182a7f3e1","article-title":"Evaluation of lipid layer thickness measurement of the tear film as a diagnostic tool for Meibomian gland dysfunction","volume":"32","author":"D Finis","year":"2013","journal-title":"Cornea"},{"key":"pone.0267118.ref018","doi-asserted-by":"crossref","first-page":"4076","DOI":"10.1167\/iovs.16-19251","article-title":"Analysis of Factors Associated With the Tear Film Lipid Layer Thickness in Normal Eyes and Patients With Dry Eye Syndrome","volume":"57","author":"JW Jung","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"pone.0267118.ref019","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1167\/iovs.10-6997b","article-title":"The international workshop on meibomian gland dysfunction: report of the definition and classification subcommittee","volume":"52","author":"JD Nelson","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"pone.0267118.ref020","doi-asserted-by":"crossref","first-page":"3996","DOI":"10.1167\/iovs.15-18467","article-title":"Functional and Morphologic Changes of Meibomian Glands in an Asymptomatic Adult Population","volume":"57","author":"NS Yeotikar","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"pone.0267118.ref021","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.clae.2010.02.003","article-title":"Tear film dynamics and lipid layer characteristics\u2014effect of age and gender","volume":"33","author":"C Maissa","year":"2010","journal-title":"Cont Lens Anterior Eye"},{"key":"pone.0267118.ref022","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.ophtha.2014.12.018","article-title":"Increased Tear Fluid Production as a Compensatory Response to Meibomian Gland Loss: A Multicenter Cross-sectional Study","volume":"122","author":"R Arita","year":"2015","journal-title":"Ophthalmology"},{"key":"pone.0267118.ref023","first-page":"e1116","article-title":"Meibomian gland inversion: under-recognized entity","volume":"97","author":"WF Siah","year":"2019","journal-title":"Acta Ophthalmol"},{"key":"pone.0267118.ref024","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.2147\/OPTH.S261783","article-title":"Anterior Lamellar Recession versus Posterior Lamellar Tarsal Rotation for Lower Lid Trachomatous Trichiasis: A Randomized Controlled Trial","volume":"14","author":"FM Abdelaziz","year":"2020","journal-title":"Clin Ophthalmol"},{"key":"pone.0267118.ref025","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/sj.eye.6700224","article-title":"Correlation of lipid layer thickness measurements with fluorescein tear film break-up time and Schirmer\u2019s test","volume":"17","author":"MA Isreb","year":"2003","journal-title":"Eye (Lond)"},{"key":"pone.0267118.ref026","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/sj.eye.6701611","article-title":"Tear film lipid layer thickness and ocular comfort after meibomian therapy via latent heat with a novel device in normal subjects","volume":"19","author":"M Mitra","year":"2005","journal-title":"Eye (Lond)"},{"key":"pone.0267118.ref027","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1097\/IOP.0000000000000281","article-title":"The BLICK Mnemonic for Clinical\u2013Anatomical Assessment of Patients With Epiphora","volume":"30","author":"DT Tse","year":"2014","journal-title":"Ophthalmic Plast Reconstr Surg"},{"key":"pone.0267118.ref028","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3341\/kjo.2018.0012","article-title":"Evaluation of Tear Film Lipid Layer Thickness Measurements Obtained Using an Ocular Surface Interferometer in Nasolacrimal Duct Obstruction Patients","volume":"32","author":"SM Lee","year":"2018","journal-title":"Korean J Ophthalmol"},{"key":"pone.0267118.ref029","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S0021-5155(01)00417-8","article-title":"Tear Lipid Layer Interference Changes After Dacryocystorhinostomy","volume":"45","author":"M Kubo","year":"2001","journal-title":"Jpn J Ophthalmol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0267118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T13:35:56Z","timestamp":1649943356000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0267118"}},"subtitle":[],"editor":[{"given":"Michael","family":"Mimouni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,4,14]]},"references-count":29,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,4,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0267118","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,14]]}}}