{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:06:47Z","timestamp":1789834007054,"version":"4.0.1"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T00:00:00Z","timestamp":1650326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Aim<\/jats:title><jats:p>Portopulmonary hypertension (PoPH) is a rare and serious complication of liver cirrhosis and portal hypertension that can interfere with liver transplantation (LT). We evaluated the prevalence of PoPH and the clinical features of right ventricular systolic pressure (RVSP), which is equivalent to pulmonary artery systolic pressure, in LT candidates.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Methods<\/jats:title><jats:p>This was a single-center retrospective study. A total of 157 Japanese patients with decompensated liver cirrhosis or portal hypertension (76 men, median age = 52 years [range: 18\u201368 years]) were enrolled. The relationships between RVSP and clinical parameters, and the prevalence of PoPH in LT candidates, were evaluated.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Results<\/jats:title><jats:p>The cardiological parameters were as follows: brain natriuretic peptide (BNP), 39.1 (4.0\u2013780.5) pg\/mL; RVSP, 31.2 (16.0\u2013122.4) mmHg; ejection fraction, 58% (28\u201372%); and mean peak tricuspid regurgitation velocity, 2.3 (1.5\u20135.3) m\/s. The RVSP was significantly higher in females (<jats:italic>p<\/jats:italic>= 0.02) and primary biliary cholangitis (PBC) patients (<jats:italic>p<\/jats:italic>= 0.01), and was weakly correlated with the BNP level (r = 0.40,<jats:italic>p<\/jats:italic>= 0.01). For RVSPs of &lt; 36 and \u2265 36 mmHg, the 5-year survival rates were 36.1%<jats:italic>versus<\/jats:italic>34.1%, and 85.4%<jats:italic>versus<\/jats:italic>85.3%, in non-LT and LT cases, respectively (<jats:italic>p<\/jats:italic>= 0.47 and 0.69, respectively). Among six patients with an RVSP \u2265 50 mmHg, three (1.9%) were diagnosed with PoPH and treated with vasodilators.<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Conclusions<\/jats:title><jats:p>PoPH was observed in 3 cases (1.9%) in 157 LT candidates. In patients with suspected mild pulmonary hypertension (RVSP, 36 - 50 mmHg), LT was successfully performed.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0267125","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T17:36:49Z","timestamp":1650389809000},"page":"e0267125","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Portopulmonary hypertension and the risk of high right ventricular systolic pressure in liver transplant candidates"],"prefix":"10.1371","volume":"17","author":[{"given":"Ryoko","family":"Hayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1248-4324","authenticated-orcid":true,"given":"Tomomi","family":"Kogiso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kana","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Egawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhisa","family":"Hagiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsutoshi","family":"Tokushige","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,4,19]]},"reference":[{"issue":"4","key":"pone.0267125.ref001","first-page":"849","article-title":"Pulmonary 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