{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:45:45Z","timestamp":1781311545717,"version":"3.54.1"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T00:00:00Z","timestamp":1650326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["141811\/2020-0"],"award-info":[{"award-number":["141811\/2020-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Introduction<\/jats:title>\n<jats:p>Depression is a serious and widespread mental health disorder. Although effective treatment does exist, a significant proportion of patients with depression fail to respond to antidepressant treatment trials, a condition named treatment-resistant depression. Efficient approach should be given this condition in order to revert the burden caused by depression. Clinical practice guidelines (CPGs) are evidence-based health promotion instruments to improve diagnosis and treatment. CPGs recommendations for treatment-resistant depression must be trustworthy. The objective of the proposed study is to systematically identify, appraise the quality of CPGs for the treatment of depression and elaborate a synthesis of recommendations for treatment-resistant depression of CPGs considered to be of high quality and with high quality recommendations.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods and analysis<\/jats:title>\n<jats:p>We will search the databases of organizations, such as PubMed, Embase, Cochrane Library, PsycInfo, and the Virtual Health Library, and organizations that develop CPGs. Three independent researchers will assess the quality of the CPGs and their recommendations using the AGREE II and AGREE-REX instruments, respectively. Given the identification of divergences and convergences as well as weak and strong points among high quality CPGs, our work may help developers, clinicians and eventually patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Ethics and dissemination<\/jats:title>\n<jats:p>No ethical approval is required for a systematic review, as no patient data will be used. The research results will be disseminated in conferences and submitted to a peer reviewed journal.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0267323","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T17:36:15Z","timestamp":1650389775000},"page":"e0267323","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Recommendations for the pharmacological treatment of treatment-resistant depression: A systematic review protocol"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4375-3729","authenticated-orcid":true,"given":"Franciele Cordeiro","family":"Gabriel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Airton Tetelbom","family":"Stein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Oliveira","family":"de Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9ssica Caroline Henrique","family":"Fontes-Mota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8693-3121","authenticated-orcid":true,"given":"Itamires Ben\u00edcio","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila da Silva","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f4nica Cristiane","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9rio","family":"Fr\u00e1guas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0751-8932","authenticated-orcid":true,"given":"Ivan D.","family":"Florez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo Telles","family":"Correia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0886-368X","authenticated-orcid":true,"given":"Eliane","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,4,19]]},"reference":[{"key":"pone.0267323.ref001","unstructured":"World Health Organization. Depression and other common mental disorders: global health estimates [Internet]. Geneva: WHO; 2017 [cited 2017 Dec 8]. Available from: http:\/\/apps.who.int\/iris\/bitstream\/10665\/254610\/1\/WHO-MSD-MER-2017.2-eng.pdf"},{"key":"pone.0267323.ref002","volume-title":"Affective disorders: the instruments of psychiatric research","author":"C. 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The appraisal of guidelines research & evaluation: recommendation excellence (AGREE-REX) [Internet]. [place unknown]: AGREE; 2019 [cited 2019 May 17]. Available from: https:\/\/www.agreetrust.org\/wp-content\/uploads\/2019\/04\/AGREE-REX-2019.pdf"},{"key":"pone.0267323.ref023","doi-asserted-by":"crossref","first-page":"e205535","DOI":"10.1001\/jamanetworkopen.2020.5535","article-title":"Development and validation of a tool to assess the quality of clinical practice guideline recommendations","volume":"3","author":"MC Brouwers","year":"2020","journal-title":"JAMA Netw Open"},{"key":"pone.0267323.ref024","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jclinepi.2020.05.025","article-title":"What to do with all the AGREEs? 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