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Yet evidence suggests that activating CRF-expressing neurons in the central amygdala (CeA) or nucleus accumbens (NAc) can magnify incentive motivation in absence of distress, at least for sucrose rewards. However, traditional CRF hypotheses in addiction neuroscience are primarily directed toward drug rewards. The question remains open whether CRF systems can similarly act via incentive motivation mechanisms to promote pursuit of drug rewards, such as cocaine. Here we tested whether optogenetic excitation of CRF-containing neurons in either NAc medial shell, lateral CeA, or dorsolateral BNST of transgenic <jats:italic>Crh<\/jats:italic>-Cre+ rats would spur preference and pursuit of a particular laser-paired cocaine reward over an alternative cocaine reward, and whether excitation served as a positively-valenced incentive itself, through laser self-stimulation tests. We report that excitation of CRF-containing neurons in either NAc or CeA recruited mesocorticolimbic circuitry to amplify incentive motivation to pursue the laser-paired cocaine: focusing preference on the laser-paired cocaine reward in a two-choice task, and spurred pursuit as doubled breakpoint in a progressive ratio task. Crucially indicating positive-valence, excitation of CRF neurons in NAc and CeA also was actively sought after by most rats in self-stimulation tasks. Conversely, CRF neuronal activation in BNST was never self-stimulated, but failed to enhance cocaine consumption. Collectively, we find that NAc and CeA CRF-containing neurons can amplify pursuit and consumption of cocaine by positively-valenced incentive mechanisms, without any aversive distress.<\/jats:p>","DOI":"10.1371\/journal.pone.0267345","type":"journal-article","created":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T17:23:24Z","timestamp":1651598604000},"page":"e0267345","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Corticotropin releasing factor (CRF) systems: Promoting cocaine pursuit without distress via incentive motivation"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8385-9229","authenticated-orcid":true,"given":"Hannah M.","family":"Baumgartner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeliene","family":"Granillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Schulkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent C.","family":"Berridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,5,3]]},"reference":[{"issue":"Pt B","key":"pone.0267345.ref001","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.neuropharm.2013.05.024","article-title":"Addiction as a stress surfeit disorder","volume":"76","author":"GF Koob","year":"2014","journal-title":"Neuropharmacology"},{"key":"pone.0267345.ref002","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/npp.2015.142","article-title":"Stress-Induced Reinstatement of Drug Seeking: 20 Years of Progress","volume":"41","author":"JR Mantsch","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"pone.0267345.ref003","first-page":"125","article-title":"Pathways to relapse: the neurobiology of drug- and stress-induced relapse to drug-taking","volume":"25","author":"J. 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