{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T19:07:30Z","timestamp":1770836850084,"version":"3.50.1"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Australia-Indonesia Institute, Department of Foreign Affairs and Trade, Australian Government","award":["AII2018\/19073"],"award-info":[{"award-number":["AII2018\/19073"]}]},{"name":"Indonesian Endowment Fund for Education (LPDP), Ministry of Finance, Indonesia Government","award":["20161012049462"],"award-info":[{"award-number":["20161012049462"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objectives<\/jats:title>\n<jats:p>To report the prevalence of total diabetes in pregnancy (TDP) and diabetes-related microvascular complications among Indonesian pregnant women.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>We conducted a community-based cross-sectional study with multi-stage, cluster random sampling to select the participating community health centers (CHC) in Jogjakarta, Indonesia between July 2018-November 2019. All pregnant women in any trimester of pregnancy within the designated CHC catchment area were recruited. Capillary fasting blood glucose (FBG) and blood glucose (BG) at 1-hour (1-h), and 2-hour (2-h) post oral glucose tolerance test (OGTT) were measured. TDP was defined as the presence of pre-existing diabetes or diabetes in pregnancy (FBG \u22657.0 mmol\/L, or 2-h OGTT \u226511.1 mmol\/L, or random BG \u226511.1 mmol\/L with diabetes symptoms). Disc and macula-centered retinal photographs were captured to assess diabetic retinopathy (DR). Blood pressure, HbA1c and serum creatinine levels were also measured.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 631\/664 (95%) eligible pregnant women were included. The median age was 29 (IQR 26\u201334) years. The prevalence of TDP was 1.1% (95%CI 0.5, 2.3). It was more common in women with chronic hypertension (<jats:italic>p<\/jats:italic> = 0.028) and a family history of diabetes (<jats:italic>p<\/jats:italic> = 0.015). Among the TDP group, 71% had a high HbA1c, but no DR nor nephropathy were observed.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Although a very low prevalence of TDP and no diabetes-related microvascular complications were documented in this population, there is still a need for a screening program for diabetes in pregnancy. Once diabetes has been identified, appropriate management can then be provided to prevent adverse outcomes.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0267663","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T18:10:02Z","timestamp":1655316602000},"page":"e0267663","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prevalence of diabetes in pregnancy and microvascular complications in native Indonesian women: The Jogjakarta diabetic retinopathy initiatives in pregnancy (Jog-DRIP)"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0247-5387","authenticated-orcid":true,"given":"Felicia","family":"Widyaputri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyndell L.","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiara Putri","family":"Utami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annisa Pelita","family":"Harti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela Nurini","family":"Agni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3643-5925","authenticated-orcid":true,"given":"Detty Siti","family":"Nurdiati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tri Wahyu","family":"Widayanti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Supanji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Firman Setya","family":"Wardhana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Eko","family":"Prayogo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0366-8335","authenticated-orcid":true,"given":"Muhammad Bayu","family":"Sasongko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2022,6,15]]},"reference":[{"key":"pone.0267663.ref001","doi-asserted-by":"crossref","first-page":"23987","DOI":"10.3402\/gha.v7.23987","article-title":"The burden of diabetes mellitus during pregnancy in low- and middle-income countries: A systematic review","volume":"7","author":"L Kanguru","year":"2014","journal-title":"Glob Health Action"},{"issue":"Suppl 1","key":"pone.0267663.ref002","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.2337\/dc18-S002","article-title":"2. 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Microvascular complications and foot care: Standards of medical care in diabetes-2018.","author":"American Diabetes Association","journal-title":"Diabetes care"},{"key":"pone.0267663.ref004","author":"International Diabetes Federation.","year":"2019","journal-title":"IDF diabetes atlas 9th edition"},{"issue":"5","key":"pone.0267663.ref005","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.2337\/dc08-9020","article-title":"Managing preexisting diabetes for pregnancy: summary of evidence and consensus recommendations for care","volume":"31","author":"JL Kitzmiller","year":"2008","journal-title":"Diabetes Care"},{"issue":"3","key":"pone.0267663.ref006","doi-asserted-by":"crossref","first-page":"676","DOI":"10.2337\/dc09-1848","article-title":"International Association of Diabetes and Pregnancy Study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy","volume":"33","author":"International Association of Diabetes and Pregnancy Study Groups Consensus Panel","year":"2010","journal-title":"Diabetes Care"},{"issue":"3","key":"pone.0267663.ref007","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.diabres.2013.10.012","article-title":"Diagnostic criteria and classification of hyperglycaemia first detected in pregnancy: a World Health Organization guideline","volume":"103","author":"World Health Organization","year":"2014","journal-title":"Diabetes Res Clin Pract"},{"key":"pone.0267663.ref008","article-title":"ADIPS consensus guidelines for the testing and diagnosis of hyperglycaemia in pregnancy in Australia and New Zealand","author":"A Nankervis","year":"2014"},{"issue":"2","key":"pone.0267663.ref009","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.diabres.2013.11.003","article-title":"Global estimates of the prevalence of hyperglycaemia in pregnancy","volume":"103","author":"L Guariguata","year":"2014","journal-title":"Diabetes Res Clin Pract"},{"key":"pone.0267663.ref010","volume-title":"Profil kesehatan Provinsi Daerah Istimewa Yogyakarta tahun 2018","author":"Dinas Kesehatan Daerah Istimewa Yogyakarta","year":"2019"},{"key":"pone.0267663.ref011","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ajo.2017.06.019","article-title":"Prevalence of diabetic retinopathy and blindness in Indonesian adults with type 2 diabetes","volume":"181","author":"MB Sasongko","year":"2017","journal-title":"Am J Ophthalmol"},{"issue":"1","key":"pone.0267663.ref012","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1080\/09286586.2016.1255763","article-title":"Rationale and methodology for a community-based study of diabetic retinopathy in an Indonesian population with type 2 diabetes mellitus: The Jogjakarta Eye Diabetic Study in the Community.","volume":"24","author":"MB Sasongko","year":"2017","journal-title":"Ophthalmic Epidemiol"},{"issue":"1","key":"pone.0267663.ref013","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0168-8227(88)80079-2","article-title":"Capillary glucose determination in the screening of gestational diabetes","volume":"5","author":"E Meriggi","year":"1988","journal-title":"Diabetes Res Clin Pract"},{"issue":"7","key":"pone.0267663.ref014","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S","article-title":"Definition, diagnosis and classification of diabetes mellitus and its complications. 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ETDRS report number 10","volume":"98","author":"Early Treatment Diabetic Retinopathy Study Research Group","year":"1991","journal-title":"Ophthalmology"},{"key":"pone.0267663.ref016","year":"2008"},{"issue":"5","key":"pone.0267663.ref017","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1111\/ajo.12399","article-title":"The SOMANZ guidelines for the management of hypertensive disorders of pregnancy 2014.","volume":"55","author":"SA Lowe","year":"2015","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"pone.0267663.ref018","author":"World Health Organization","journal-title":"BMI classification. Global database on body mass index."},{"issue":"Suppl 1","key":"pone.0267663.ref019","doi-asserted-by":"crossref","first-page":"S137","DOI":"10.2337\/dc18-S013","article-title":"13. 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