{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:29:58Z","timestamp":1792542598477,"version":"4.5.0"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009891","name":"International Society of Nephrology","doi-asserted-by":"publisher","award":["2018-2"],"award-info":[{"award-number":["2018-2"]}],"id":[{"id":"10.13039\/100009891","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Despite the guidelines provided by the World Health Organization for the treatment of malaria, treatment failure occurs in many hospitalized patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Objective<\/jats:title>\n<jats:p>Evaluate whether blood cell count parameters may serve as predictors for malaria treatment.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Methodology<\/jats:title>\n<jats:p>A cross-sectional study with a quantitative approach.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Results<\/jats:title>\n<jats:p>Of the 219 patients, 21.5% showed failure to antimalarial treatment, Patient with 21 and 40 years (72.6%), male (53.4%), from peri-urban area (47.5%), with high parasitemia (59.8%), treated with Arthemeter (90.9%) and the mortality were 5.9%. Significant associations were observed between occupation, level of parasitemia and outcome with resistance to antimalarial treatment (p&lt;0.05). Patients with normal Hb [OR: 0.75 (95% CI: 0.39\u20131.44), p = 0.393], RBC [OR: 0.83 (95% CI: 0.40\u20131.72), p = 0.632], RDW [OR: 0.54 (95% CI: 0.27\u20131.09), p = 0.088], MCV [OR: 0.61 (95% CI: 0.28\u20131.31), p = 0.204] were less likely to have malaria treatment failures after artemisinin-based therapy failure. In contrast, those with normal values of segmented neutrophils [OR: 0.32 (95% CI: 0.11\u20130.96), p = 0.042] and lymphocyte counts [OR: 0.24 (95% CI: 0.05\u20131.04), p = 0.055]. We also found that patients with significant low levels of Hct [OR: 0.31 (95% CI: 0.15\u20130.64) p = 0.002], and high leukocytes [OR: 8.88 (95% CI: 2.02\u201337.2), p = 0.004] and normal platelet values [OR: 1.42 (95% CI: 0.73\u20132.95), p = 0.280] demonstrated high probability of treatment failure.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The importance of blood cell count parameters in monitoring malaria therapy necessitates the urgent need to re-evaluate Artemether-based therapy. Future studies involving more participants in different settings are needed to provide further evidence.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0267671","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T17:35:27Z","timestamp":1651772127000},"page":"e0267671","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Evaluation of blood cell count parameters as predictors of treatment failure of malaria in Angola: An observational study"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2341-9133","authenticated-orcid":true,"given":"Euclides Nenga Manuel","family":"Sacomboio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cruz","family":"dos Santos Sebasti\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana Teresa da Costa","family":"Salvador","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquim Ant\u00f3nio","family":"Jo\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisy Viviana Sebasti\u00e3o","family":"Bapolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3255-8968","authenticated-orcid":true,"given":"Ngiambudulu M.","family":"Francisco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana","family":"Morais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Ekundi","family":"Valentim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,5,5]]},"reference":[{"key":"pone.0267671.ref001","unstructured":"ANGOLA. 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