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TMD comprises two groups of disorders, namely intra-articular TMD and masticatory muscle disorders. There is still difficulty in establishing the effectiveness of different therapeutic modalities for TMD with robust evidence, despite the large volume of publications in the area. The lack of outcomes standardization may represent a limiting factor in the search for scientific evidence.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Objective<\/jats:title><jats:p>This study aims to develop a core outcome sets (COS) for clinical trials in intra-articular TMD and masticatory muscle disorders.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Methods<\/jats:title><jats:p>The protocol for determining the COS-TMD will consist of three phases: 1. Synthesis of TMD Management Intervention Outcomes. The identification of outcomes will be carried out through a systematic review, which will include randomized clinical trials that evaluated the effectiveness of interventions used in TMD management. 2. Through a two-round international Delphi survey, the list of outcomes will be scored by three panels of stakeholders. 3. A representative sample of key stakeholders will be invited to participate in a face-to-face meeting where they can discuss the results of the Delphi survey and determine the final core set.<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Conclusions<\/jats:title><jats:p>The implementation of this protocol will determine the COS-TMD, which will be made available for use in all TMD clinical studies. The use of COS when planning and reporting TMD clinical trials will reduce the risk of publication bias and enable proper comparison of results found by different studies.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0267722","type":"journal-article","created":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T18:49:33Z","timestamp":1651171773000},"page":"e0267722","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Development of core outcome sets for clinical trials in temporomandibular disorders: A study protocol"],"prefix":"10.1371","volume":"17","author":[{"given":"Nat\u00e1lia dos Reis","family":"Ferreira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Miguel Machado","family":"Marto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleli T\u00f4rres","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Jo\u00e3o","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5997-9693","authenticated-orcid":true,"given":"Marcos Fabio","family":"DosSantos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2022,4,28]]},"reference":[{"issue":"1","key":"pone.0267722.ref001","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cden.2010.08.007","article-title":"Differential diagnosis of temporomandibular disorders and other orofacial pain disorders","volume":"55","author":"JP Okeson","year":"2011","journal-title":"Dent Clin North Am"},{"issue":"1","key":"pone.0267722.ref002","doi-asserted-by":"crossref","first-page":"6","DOI":"10.11607\/jop.1151","article-title":"Diagnostic Criteria for Temporomandibular Disorders (DC\/TMD) for Clinical and Research Applications: recommendations of the International RDC\/TMD Consortium Network* and Orofacial Pain Special Interest Groupdagger","volume":"28","author":"E Schiffman","year":"2014","journal-title":"J Oral Facial Pain Headache"},{"issue":"1","key":"pone.0267722.ref003","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/joor.12132","article-title":"Expanding the taxonomy of the diagnostic criteria for temporomandibular disorders","volume":"41","author":"CC Peck","year":"2014","journal-title":"Journal of Oral Rehabilitation"},{"unstructured":"National Institute of Dental and Craniofacial Research. 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temporomandibular disorders: A systematic review","volume":"46","author":"N Ferreira","year":"2018","journal-title":"J Craniomaxillofac Surg"},{"issue":"3","key":"pone.0267722.ref014","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.cden.2013.04.006","article-title":"Epidemiology, diagnosis, and treatment of temporomandibular disorders","volume":"57","author":"F Liu","year":"2013","journal-title":"Dent Clin North Am"},{"issue":"7","key":"pone.0267722.ref015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta24070","article-title":"Oral splints for patients with temporomandibular disorders or bruxism: a systematic review and economic evaluation","volume":"24","author":"P Riley","year":"2020","journal-title":"Health Technol Assess"},{"issue":"5","key":"pone.0267722.ref016","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.bjoms.2020.02.007","article-title":"Botulinum toxin in the management of temporomandibular disorders: a systematic 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Williamson","year":"2017","journal-title":"Trials"},{"issue":"1","key":"pone.0267722.ref020","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1186\/s13063-016-1555-2","article-title":"How to select outcome measurement instruments for outcomes included in a \"Core Outcome Set\"\u2014a practical guideline","volume":"17","author":"CA Prinsen","year":"2016","journal-title":"Trials"},{"issue":"11","key":"pone.0267722.ref021","doi-asserted-by":"crossref","first-page":"e1002447","DOI":"10.1371\/journal.pmed.1002447","article-title":"Core Outcome Set-STAndards for Development: The COS-STAD recommendations","volume":"14","author":"JJ Kirkham","year":"2017","journal-title":"PLoS Med"},{"issue":"1","key":"pone.0267722.ref022","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s13063-019-3230-x","article-title":"Core Outcome Set-STAndardised Protocol Items: the COS-STAP Statement","volume":"20","author":"JJ Kirkham","year":"2019","journal-title":"Trials"},{"issue":"3","key":"pone.0267722.ref023","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.pain.2003.08.001","article-title":"Core outcome domains for chronic pain clinical trials: IMMPACT recommendations","volume":"106","author":"DC Turk","year":"2003","journal-title":"Pain"},{"issue":"1\u20132","key":"pone.0267722.ref024","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.pain.2004.09.012","article-title":"Core outcome measures for chronic pain clinical trials: IMMPACT recommendations","volume":"113","author":"RH Dworkin","year":"2005","journal-title":"Pain"},{"issue":"4","key":"pone.0267722.ref025","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1046\/j.1365-2648.2000.t01-1-01567.x","article-title":"Research guidelines for the Delphi survey technique","volume":"32","author":"F Hasson","year":"2000","journal-title":"J Adv Nurs"},{"issue":"4","key":"pone.0267722.ref026","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jclinepi.2010.04.026","article-title":"GRADE guidelines: 1. 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