{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:40:23Z","timestamp":1791423623404,"version":"4.3.3"},"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T00:00:00Z","timestamp":1652832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Hispanic persons living in the United States (U.S.) are at higher risk of infection and death from coronavirus disease 2019 (COVID-19) compared with non-Hispanic persons. Whether this disparity exists among critically ill patients with COVID-19 is unknown.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Objective<\/jats:title>\n<jats:p>To evaluate ethnic disparities in mortality among critically ill adults with COVID-19 enrolled in the Study of the Treatment and Outcomes in Critically Ill Patients with COVID-19 (STOP-COVID).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Multicenter cohort study of adults with laboratory-confirmed COVID-19 admitted to intensive care units (ICU) at 67 U.S. hospitals from March 4 to May 9, 2020. Multilevel logistic regression was used to evaluate 28-day mortality across racial\/ethnic groups.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 2153 patients were included (994 [46.2%] Hispanic and 1159 [53.8%] non-Hispanic White). The median (IQR) age was 62 (51\u201371) years (non-Hispanic White, 66 [57\u201374] years; Hispanic, 56 [46\u201367] years), and 1462 (67.9%) were men. Compared with non-Hispanic White patients, Hispanic patients were younger; were less likely to have hypertension, chronic obstructive pulmonary disease, coronary artery disease, or heart failure; and had longer duration of symptoms prior to ICU admission. During median (IQR) follow-up of 14 (7\u201324) days, 785 patients (36.5%) died. In analyses adjusted for age, sex, clinical characteristics, and hospital size, Hispanic patients had higher odds of death compared with non-Hispanic White patients (OR, 1.44; 95% CI, 1.12\u20131.84).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Among critically ill adults with COVID-19, Hispanic patients were more likely to die than non-Hispanic White patients, even though they were younger and had lower comorbidity burden. This finding highlights the need to provide earlier access to care to Hispanic individuals with COVID-19, especially given our finding of longer duration of symptoms prior to ICU admission among Hispanic patients. In addition, there is a critical need to address ongoing disparities in post hospital discharge care for patients with COVID-19.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0268022","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T17:34:55Z","timestamp":1652895295000},"page":"e0268022","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["Hispanic ethnicity and mortality among critically ill patients with COVID-19"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8670-3644","authenticated-orcid":true,"given":"Ana C.","family":"Ricardo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9635-7554","authenticated-orcid":true,"given":"Stephanie M.","family":"Toth-Manikowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Meza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Joo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5747-2151","authenticated-orcid":true,"given":"Shruti","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepa G.","family":"Lazarous","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7875-090X","authenticated-orcid":true,"given":"David E.","family":"Leaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6580-4080","authenticated-orcid":true,"given":"James P.","family":"Lash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the STOP-COVID Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,5,18]]},"reference":[{"key":"pone.0268022.ref001","unstructured":"Centers for Disease Control and Prevention. Demographic Trends of COVID-19 cases and deaths in the US reported to CDC. Available: https:\/\/covid.cdc.gov\/covid-data-tracker\/#demographics."},{"key":"pone.0268022.ref002","unstructured":"Centers for Disease Control and Prevention. Risk for COVID-19 Infection, Hospitalization, and Death By Race\/Ethnicity. 11 Sep 2021 [cited 25 Oct 2021]. Available: https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/covid-data\/investigations-discovery\/hospitalization-death-by-race-ethnicity.html."},{"key":"pone.0268022.ref003","doi-asserted-by":"crossref","first-page":"362","DOI":"10.7326\/M20-6306","article-title":"Racial and Ethnic Disparities in COVID-19-Related Infections, Hospitalizations, and Deaths: A Systematic Review","volume":"174","author":"K Mackey","year":"2021","journal-title":"Ann Intern Med"},{"key":"pone.0268022.ref004","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1001\/jamainternmed.2020.3596","article-title":"Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US","volume":"180","author":"S Gupta","year":"2020","journal-title":"JAMA Intern Med"},{"key":"pone.0268022.ref005","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)\u2014a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"PA Harris","year":"2009","journal-title":"J Biomed Inform"},{"key":"pone.0268022.ref006","doi-asserted-by":"crossref","first-page":"m1985","DOI":"10.1136\/bmj.m1985","article-title":"Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study","volume":"369","author":"AB Docherty","year":"2020","journal-title":"BMJ"},{"key":"pone.0268022.ref007","article-title":"OpenSAFELY: factors associated with COVID-19 death in 17 million patients","author":"EJ Williamson","year":"2020","journal-title":"Nature"},{"key":"pone.0268022.ref008","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1056\/NEJMsa2011686","article-title":"Hospitalization and Mortality among Black Patients and White Patients with Covid-19","volume":"382","author":"EG Price-Haywood","year":"2020","journal-title":"New England Journal of Medicine"},{"key":"pone.0268022.ref009","first-page":"166","article-title":"Risk factors for mortality among COVID-19 patients","author":"O Albitar","year":"2020","journal-title":"Diabetes Research and Clinical Practice"},{"key":"pone.0268022.ref010","article-title":"AKI Treated with Renal Replacement Therapy in Critically Ill Patients with COVID-19","author":"S Gupta","year":"2020","journal-title":"J Am Soc Nephrol"},{"key":"pone.0268022.ref011","article-title":"Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19","author":"S Gupta","year":"2020","journal-title":"JAMA Intern Med"},{"key":"pone.0268022.ref012","doi-asserted-by":"crossref","first-page":"e1003379","DOI":"10.1371\/journal.pmed.1003379","article-title":"Patterns of COVID-19 testing and mortality by race and ethnicity among United States veterans: A nationwide cohort study","volume":"17","author":"CT Rentsch","year":"2020","journal-title":"PLoS Med"},{"key":"pone.0268022.ref013","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1186\/s12889-021-11431-2","article-title":"Disparities in COVID-19 hospitalizations and mortality among black and Hispanic patients: cross-sectional analysis from the greater Houston metropolitan area","volume":"21","author":"AP Pan","year":"2021","journal-title":"BMC Public Health"},{"key":"pone.0268022.ref014","doi-asserted-by":"crossref","first-page":"100455","DOI":"10.1016\/j.eclinm.2020.100455","article-title":"The association of race and COVID-19 mortality","volume":"25","author":"L Golestaneh","year":"2020","journal-title":"EClinicalMedicine"},{"key":"pone.0268022.ref015","doi-asserted-by":"crossref","first-page":"e206","DOI":"10.1093\/cid\/ciaa1012","article-title":"Risk Factors for Intensive Care Unit Admission and In-hospital Mortality Among Hospitalized Adults Identified through the US Coronavirus Disease 2019 (COVID-19)-Associated Hospitalization Surveillance Network (COVID-NET)","volume":"72","author":"L Kim","year":"2021","journal-title":"Clin Infect Dis"},{"key":"pone.0268022.ref016","doi-asserted-by":"crossref","first-page":"m1966","DOI":"10.1136\/bmj.m1966","article-title":"Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study","volume":"369","author":"CM Petrilli","year":"2020","journal-title":"BMJ"},{"key":"pone.0268022.ref017","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.2105\/AJPH.2012.301103","article-title":"Hispanic mortality paradox: a systematic review and meta-analysis of the longitudinal literature","volume":"103","author":"JM Ruiz","year":"2013","journal-title":"Am J Public Health"},{"key":"pone.0268022.ref018","doi-asserted-by":"crossref","first-page":"e1921165","DOI":"10.1001\/jamanetworkopen.2019.21165","article-title":"A Commentary on the Latin American Paradox","volume":"3","author":"AF Abra\u00eddo-Lanza","year":"2020","journal-title":"JAMA Netw Open"},{"key":"pone.0268022.ref019","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.2105\/AJPH.89.10.1543","article-title":"The Latino mortality paradox: a test of the \u201csalmon bias\u201d and healthy migrant hypotheses","volume":"89","author":"AF Abra\u00eddo-Lanza","year":"1999","journal-title":"Am J Public Health"},{"key":"pone.0268022.ref020","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1001\/jama.2020.8598","article-title":"COVID-19 and Racial\/Ethnic Disparities","volume":"323","author":"M Webb Hooper","year":"2020","journal-title":"JAMA"},{"key":"pone.0268022.ref021","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1001\/jama.2020.26443","article-title":"Racial and Ethnic Health Disparities Related to COVID-19","volume":"325","author":"L Lopez","year":"2021","journal-title":"JAMA"},{"key":"pone.0268022.ref022","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1093\/infdis\/jiaa474","article-title":"COVID-19 Pandemic: Disparate Health Impact on the Hispanic\/Latinx Population in the United States","volume":"222","author":"R Macias Gil","year":"2020","journal-title":"J Infect Dis"},{"key":"pone.0268022.ref023","doi-asserted-by":"crossref","first-page":"5493","DOI":"10.1038\/s41467-020-19057-5","article-title":"SARS-CoV-2 viral load is associated with increased disease severity and mortality","volume":"11","author":"J Fajnzylber","year":"2020","journal-title":"Nat Commun"},{"key":"pone.0268022.ref024","first-page":"71","article-title":"Racial and Ethnic Disparities in Receipt of Medications for Treatment of COVID-19\u2014United States, March 2020\u2013August 2021","author":"JL Wiltz","year":"2022","journal-title":"MMWR Morb Mortal Wkly Rep"}],"container-title":["PLOS 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