{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T22:32:18Z","timestamp":1781735538038,"version":"3.54.5"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T00:00:00Z","timestamp":1651622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Malaria has been strongly linked to the transmission and pathophysiology of some viral diseases. Malaria and vaccine-preventable diseases often co-exist in endemic countries but the implication of their co-existence on their transmission dynamics and control is poorly understood. The study aims to evaluate the relationships between the incidence of malaria and cases of measles and yellow fever in Africa.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>The malaria incidence, death due to malaria, measles and yellow fever data were sourced from the WHO database. Poisson and zero-inflated time-trend regression were used to model the relationships between malaria and the two vaccine-preventable diseases. <jats:italic>P<\/jats:italic>-values &lt;0.05 were considered statistically significant.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>A significant negative relationship existed between malaria incidence and measles cases (<jats:italic>P<\/jats:italic>&lt;0.05), however, malaria showed a positive relationship with yellow fever (<jats:italic>P<\/jats:italic>&lt;0.05). The relationships between death due to malaria and measles\/yellow fever cases followed similar trends but with a higher level of statistical significance (<jats:italic>P<\/jats:italic>&lt;0.001).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Malaria varied negatively with measles cases but positively with yellow fever. The relationships observed in this study could be important for the management of malaria and the studied vaccine-preventable diseases. Increase vaccination coverage and\/or malaria treatment could modulate the direction of these relationships.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0268080","type":"journal-article","created":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T17:31:00Z","timestamp":1651685460000},"page":"e0268080","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Malaria transmission in Africa: Its relationship with yellow fever and measles"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8169-4571","authenticated-orcid":true,"given":"Oluyemi A.","family":"Okunlola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3089-2578","authenticated-orcid":true,"given":"Oyetunde T.","family":"Oyeyemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,5,4]]},"reference":[{"key":"pone.0268080.ref001","unstructured":"World Health Organization. World malaria report 2021. https:\/\/www.who.int\/teams\/global-malaria-programme\/reports\/world-malaria-report-2021. Accessed 18 March 2022."},{"key":"pone.0268080.ref002","unstructured":"World Health Organization. Malaria 2021. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/malaria. Accessed 20 March 2022."},{"key":"pone.0268080.ref003","unstructured":"World Health Organization. Compendium of who malaria guidance\u2014prevention, diagnosis, treatment, surveillance and elimination 2019. https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/312082\/WHO-CDS-GMP-2019.03-eng.pdf. Accessed 20 March 2022."},{"key":"pone.0268080.ref004","doi-asserted-by":"crossref","first-page":"ix","DOI":"10.1016\/S0065-3527(03)60013-8","article-title":"Preface to the flaviviruses","volume":"60","author":"TJ Chambers","year":"2003","journal-title":"Adv Virus Res"},{"key":"pone.0268080.ref005","doi-asserted-by":"crossref","first-page":"e1001638","DOI":"10.1371\/journal.pmed.1001638","article-title":"Yellow Fever in Africa: estimating the burden of disease and impact of mass vaccination from the outbreak and serological data","volume":"11","author":"T Garske","year":"2014","journal-title":"PLoS Med"},{"key":"pone.0268080.ref006","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1146\/annurev.ento.52.110405.091454","article-title":"Yellow fever: a disease that has yet to be conquered","volume":"52","author":"AD Barrett","year":"2007","journal-title":"Annu Rev Entomol"},{"key":"pone.0268080.ref007","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1093\/trstmh\/tru092","article-title":"The whole iceberg: estimating the incidence of yellow fever virus infection from the number of severe cases","volume":"108","author":"MA Johansson","year":"2014","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"pone.0268080.ref008","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1016\/j.vaccine.2011.12.123","article-title":"Measles control in Sub-Saharan Africa: South Africa as a case study","volume":"30","author":"S Verguet","year":"2012","journal-title":"Vaccine"},{"key":"pone.0268080.ref009","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.bjid.2015.07.010","article-title":"Plasmodium falciparum and hepatitis B virus infection in Nigerian urban population","volume":"19","author":"OT Oyeyemi","year":"2015a","journal-title":"Braz J Infect Dis"},{"issue":"2","key":"pone.0268080.ref010","first-page":"84","article-title":"Maternal Plasmodium falciparum and hepatitis B virus infections in Nigeria","volume":"4","author":"OT Oyeyemi","year":"2015b","journal-title":"J Dis Global Health"},{"key":"pone.0268080.ref011","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2478\/jim-2020-0011","article-title":"Malaria and HIV infections among febrile patients in Lagos, Southwestern, Nigeria","volume":"5","author":"OT Oyeyemi","year":"2020","journal-title":"J Interdisciplinary Med"},{"key":"pone.0268080.ref012","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12936-016-1100-5","article-title":"Concurrent malaria and arbovirus infections in Kedougou, Southeastern Senegal","volume":"15","author":"A Sow","year":"2016","journal-title":"Malar J"},{"issue":"1","key":"pone.0268080.ref013","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0035-9203(87)90298-7","article-title":"Aedes aegypti and yellow fever virus: the effect of chloroquine on infection and transmission rates","volume":"81","author":"BR Miller","year":"1987","journal-title":"Trans Roy Soc Trop Med Hyg"},{"key":"pone.0268080.ref014","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4269\/ajtmh.1991.44.79","article-title":"The effect of chloroquine prophylaxis on yellow fever vaccine antibody response: comparison of plaque reduction neutralization test and enzyme-linked immunosorbent assay","volume":"44","author":"M Barry","year":"1991","journal-title":"Am J Trop Med Hyg"},{"key":"pone.0268080.ref015","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1136\/adc.2005.085274","article-title":"Placental malaria and immunity to infant measles","volume":"91","author":"S Owens","year":"2006","journal-title":"Arch Dis Child"},{"key":"pone.0268080.ref016","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1214\/09-AOAS306","article-title":"A flexible regression model for count data","volume":"4","author":"KF Sellers","year":"2010","journal-title":"Ann Appl Stat"},{"key":"pone.0268080.ref017","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1177\/1471082X17697749","article-title":"Mean-parameterized Conway\u2013Maxwell\u2013Poisson regression models for dispersed counts","volume":"17","author":"A. Huang","year":"2017","journal-title":"Stat Model"},{"key":"pone.0268080.ref018","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2307\/1269547","article-title":"Zero-inflated Poisson regression, with an application to defects in manufacturing","volume":"34","author":"D. Lambert","year":"1992","journal-title":"Technimetrics"},{"issue":"4","key":"pone.0268080.ref019","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1080\/02664763.2012.752448","article-title":"Some ridge regression estimators for the zero-inflated Poisson model","volume":"40","author":"BMG Kibria","year":"2013","journal-title":"J Appl Stat"},{"key":"pone.0268080.ref020","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1093\/comjnl\/7.4.308","article-title":"A simplex method for function minimization","volume":"7","author":"JA Nelder","year":"1965","journal-title":"Comp J"},{"key":"pone.0268080.ref021","doi-asserted-by":"crossref","first-page":"e2021041","DOI":"10.4178\/epih.e2021041","article-title":"Modeling the relationship between malaria prevalence and insecticide-treated bed nets coverage using Leroux prior Bayesian spatial generalized linear mixed models","author":"OA Okunlola","year":"2021","journal-title":"Epidemiol Health"},{"issue":"7572","key":"pone.0268080.ref022","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature15535","article-title":"The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015","volume":"526","author":"S Bhatt","year":"2015","journal-title":"Nature"},{"key":"pone.0268080.ref023","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1046\/j.1365-2915.1998.00091.x","article-title":"Permethrin-impregnated bednet effects on resting and feeding behaviour of lymphatic filariasis vector mosquitoes in Kenya","volume":"12","author":"C Bogh","year":"1998","journal-title":"Med Vet Entomol"},{"key":"pone.0268080.ref024","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.actatropica.2010.08.005","article-title":"Beyond temperature and precipitation: Ecological risk factors that modify malaria transmission","volume":"116","author":"GH Stresman","year":"2010","journal-title":"Acta Trop"},{"key":"pone.0268080.ref025","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/1475-2875-8-103","article-title":"Development of vegetable farming: a cause of the emergence of insecticide resistance in populations of Anopheles gambiae in urban areas of Benin","volume":"8","author":"AW Yadouleton","year":"2009","journal-title":"Malar J"},{"key":"pone.0268080.ref026","doi-asserted-by":"crossref","first-page":"177","DOI":"10.4269\/ajtmh.2003.68.177","article-title":"Strong association between house characteristics and malaria vectors in Sri Lanka","volume":"68","author":"F Konradsen","year":"2003","journal-title":"Am J Trop Med Hyg"},{"key":"pone.0268080.ref027","unstructured":"World Health Organization 2021. More malaria cases and deaths in 2020 linked to COVID-19 disruptions. https:\/\/www.who.int\/news\/item\/06-12-2021-more-malaria-cases-and-deaths-in-2020-linked-to-covid-19-disruptions. Accessed 22 March 2022."},{"key":"pone.0268080.ref028","unstructured":"The Global Fund. Malaria. https:\/\/www.theglobalfund.org\/en\/malaria\/?lang=en. Accessed 22 March 2022."},{"key":"pone.0268080.ref029","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S1471-4922(01)02031-1","article-title":"The past, present and future of childhood malaria mortality in Africa","volume":"17","author":"RW Snow","year":"2001","journal-title":"Trends Parasitol"},{"key":"pone.0268080.ref030","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1046\/j.1365-3156.2003.01030.x","article-title":"Malaria morbidity, treatment seeking behaviour, and mortality in a cohort of young children in rural Burkina Faso","volume":"8","author":"O Muller","year":"2003","journal-title":"Trop Med lnt Health"},{"key":"pone.0268080.ref031","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1093\/aje\/kwh001","article-title":"Spatial patterns of infant mortality in Mali: the effect of malaria endemicity","volume":"159","author":"A Gemperli","year":"2004","journal-title":"Am J Epidemiol"},{"key":"pone.0268080.ref032","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1475-2875-3-17","article-title":"The relationship between the Plasmodium falciparum parasite ratio in childhood and climate estimates of malaria transmission in Kenya","volume":"3","author":"J Omumbo","year":"2004","journal-title":"Malar J"},{"key":"pone.0268080.ref033","unstructured":"WHO and UNICEF. Estimates of national immunization coverage\u2014Nigeria 2020a. https:\/\/www.who.int\/immunization\/monitoring_surveillance\/data\/nga.pdf. Accessed 04 February 2021."},{"key":"pone.0268080.ref034","unstructured":"WHO and UNICEF (2020c). Estimates of national immunization coverage\u2014Democratic Republic of the Congo. https:\/\/www.who.int\/immunization\/monitoring_surveillance\/data\/cod.pdf. Accessed 04 February 2021."},{"key":"pone.0268080.ref035","unstructured":"WHO and UNICEF (2020c). Estimates of national immunization coverage\u2014Togo. https:\/\/www.who.int\/immunization\/monitoring_surveillance\/data\/tgo.pdf. Accessed 04 February 2021."},{"key":"pone.0268080.ref036","first-page":"3","article-title":"Possible contributing factors to the paucity of yellow fever epidemics in the Ashanti region of Ghana, West Africa","volume":"73","author":"PA Addy","year":"1996","journal-title":"East Afr Med J"},{"key":"pone.0268080.ref037","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1186\/s13071-019-3557-x","article-title":"Larval species diversity, seasonal occurrence and larval habitat preference of mosquitoes transmitting Rift Valley fever and malaria in Baringo County, Kenya","volume":"12","author":"IM Ondiba","year":"2019","journal-title":"Parasite Vector"},{"key":"pone.0268080.ref038","unstructured":"WHO. Malaria Fact Sheet 2020. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/malaria. 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