{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T19:17:11Z","timestamp":1773688631655,"version":"3.50.1"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Infantile wheezing and eczema are associated with the subsequent onset of asthma and other atopic diseases. However, there are no large population-based surveys on infantile allergic symptoms in Japan. The objective of the study was to determine the prevalence of wheezing and asthma in infants in Nagoya, Japan. This population-based cross-sectional study was performed in the metropolitan city of Nagoya, Japan. We surveyed parents to ascertain the prevalence of wheezing and eczema in infants who attended group health checkups at 3, 18, and 36 months of age. Their parents completed modified questionnaires from the International Study of Asthma and Allergies in Childhood. More than 90% of the approximately 40,000 children in each study group living in the target area were included in the survey. The prevalence of wheezing was 8%, 17%, and 13% at 3, 18, and 36 months, respectively, and was characterized by birth season. The prevalence of eczema was 24%, 30%, and 31%, at 3, 18, and 36 months, respectively. Participants born in autumn and winter had a higher incidence of eczema in each age group. Three-quarters of the children had a parental history of allergic conditions. Parental allergic diseases and male gender are risk factors for wheezing and eczema in children. This survey had a high response rate and covered almost the entire population of the target age groups in a large city. We believe that the results of this study, therefore, provide a much higher level of confidence regarding the prevalence of allergies in infants in Japan than that in previous studies with limited cohorts.<\/jats:p>","DOI":"10.1371\/journal.pone.0268092","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T17:47:54Z","timestamp":1651772874000},"page":"e0268092","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Prevalence of infantile wheezing and eczema in a metropolitan city in Japan: A complete census survey"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7442-9649","authenticated-orcid":true,"given":"Masaki","family":"Futamura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimichi","family":"Hiramitsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Kamioka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chikae","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harue","family":"Umemura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rieko","family":"Nakanishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Sugiura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuto","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1932-7973","authenticated-orcid":true,"given":"Komei","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2022,5,5]]},"reference":[{"issue":"1","key":"pone.0268092.ref001","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.alit.2019.08.010","article-title":"Nationwide survey of the prevalence of wheeze, rhino-conjunctivitis, and eczema among Japanese children in 2015.","volume":"69","author":"E Morikawa","year":"2020","journal-title":"Allergol Int"},{"issue":"1","key":"pone.0268092.ref002","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.alit.2019.06.003","article-title":"Prevalence, disease burden, and treatment reality of patients with severe, uncontrolled asthma in Japan.","volume":"69","author":"H Nagase","year":"2020","journal-title":"Allergol Int"},{"issue":"4","key":"pone.0268092.ref003","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/1346-8138.14218","article-title":"Burden of atopic dermatitis in Japanese adults: Analysis of data from the 2013 National Health and Wellness Survey","volume":"45","author":"K Arima","year":"2018","journal-title":"J Dermatol"},{"key":"pone.0268092.ref004","unstructured":"Ministry of Health L, and Welfare, Japan. 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