{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:47:42Z","timestamp":1792072062288,"version":"4.4.0"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Introduction<\/jats:title>\n<jats:p>Hypertension is one global public health emergency disease, and is one of the most critical factors for chronic diseases such as cardiovascular disease, stroke, arrhythmias, heart failure, and renal diseases. Hypertension affects quality of life of patients, however there is limited evidence on the factors that affect health related quality of life among hypertensive patients. As a result, the purpose of this study is to look into factors that affect the health-related quality of life of adult hypertensive patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>An institutional based cross-sectional study was conducted in Dessie City public health facilities from March to April 2021 with the total samples size of 376 hypertensive patients. Simple random sampling technique was employed to select study participants. World health organization health related quality of life 26 items were used to measure outcome variable. Simple linear regression analysis was done and forwarded to multivariable linear regression analysis at p-value&lt;0.2. In multivariable linear regression analysis variables whose p-value less than 0.05 at 95% confidence interval with unstandardized \u03b2-coefficient were declared as statistically significant.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 360 hypertensive patients were included in the study. The mean scores of physical, psychological, social and environmental domains were 42.93, SD (18.86), 51.78, SD (20.40), 57.31, SD (20.20) and 48.15, SD (16.26), respectively. Age, duration of antihypertensive treatment, low social support, physical inactivity, co-morbidity, being widow, khat chewing, and being single had a significant association with lower health related quality of life.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion and recommendations<\/jats:title>\n<jats:p>The health-related quality of life of hypertensive patients were found low in all domains. The findings indicate the necessity for health professionals, government, non-governmental organizations and community to pay more attention to patients\u2019 quality of life, seeking changes in the therapeutic approach in general.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0268150","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T19:01:41Z","timestamp":1664478101000},"page":"e0268150","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":42,"title":["Health related quality of life among adult hypertensive patients on treatment in Dessie City, Northeast Ethiopia"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7673-4938","authenticated-orcid":true,"given":"Kidist","family":"Adamu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amsalu","family":"Feleke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8533-3570","authenticated-orcid":true,"given":"Amare","family":"Muche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toyeb","family":"Yasin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asnakew Molla","family":"Mekonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7059-1449","authenticated-orcid":true,"given":"Muluken Genetu","family":"Chane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisay","family":"Eshete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1580-4269","authenticated-orcid":true,"given":"Anisa","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7613-7079","authenticated-orcid":true,"given":"Abel","family":"Endawkie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4577-868X","authenticated-orcid":true,"given":"Zinabu","family":"Fentaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"key":"pone.0268150.ref001","author":"FMOH","year":"2016","journal-title":"Guidelines on Clinical and Programmatic Management of Major Non Communicable Diseases"},{"key":"pone.0268150.ref002","first-page":"1","article-title":"A cross-sectional assessment of health-related quality of life (HRQoL) among hypertensive patients in Pakistan","author":"F Saleem","year":"2012"},{"key":"pone.0268150.ref003","first-page":"551","volume":"28","author":"Group THEW","year":"1998","journal-title":"Development of the World Health Organization WHOQOL-BREF Quality of Life Assessment"},{"key":"pone.0268150.ref004","author":"Introducing the WHOQOL instruments","year":"2004","journal-title":"World Heal Organ"},{"key":"pone.0268150.ref005","first-page":"1","article-title":"Profile and predictor of health-related quality of life among hypertensive patients in south-western Nigeria","volume":"8","author":"MO Ogunlana","year":"2009","journal-title":"BMC Cardiovasc Disord"},{"key":"pone.0268150.ref006","article-title":"Journal of Hypertension: Open Access Health Related Quality of Life and Associated Factors among Adult Hypertensive Patients on Jimma University Specialized Hospital, South","volume":"7","author":"A. 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