{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:20:42Z","timestamp":1789564842247,"version":"build-2803163510"},"reference-count":58,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T00:00:00Z","timestamp":1653004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["105319_159833."],"award-info":[{"award-number":["105319_159833."]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>This secondary analysis of a randomised controlled patient-blinded trial comparing effectiveness and side effect briefings in patients with chronic low back pain (CLBP) investigated the association between patients\u2019 pre-treatment expectations about minimal acupuncture treatment and pain intensity as outcome during and after the end of the treatment.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Chronic low back pain patients with a pain intensity of at least 4 on a numeric rating scale from 0 to 10 received eight sessions of minimal acupuncture treatment over 4 weeks. The primary outcome was change in pain intensity rated on a Numerical Rating Scale (NRS 0\u201310) from inclusion visit to treatment session 4 and to the end of the treatment. Patients\u2019 expectations about the effectiveness of acupuncture were assessed using the Expectation for Treatment Scale (ETS) before randomization. Linear regression was applied to investigate whether patients\u2019 pre-treatment expectations predicted changes in pain intensity during and after treatment.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 142 CLBP patients (40.1 \u00b1 12.5 years; 65.5% female) were included in our analysis. Patients\u2019 pre-treatment expectations about acupuncture treatment were associated with changes in pain intensity after four sessions of minimal acupuncture treatment (<jats:italic>b<\/jats:italic> = -0.264, p = 0.002), but not after the end of the treatment. This association was found in females and males.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Our results imply that higher pre-treatment expectations only lead to larger reductions in pain intensity in the initial phase of a treatment, with a similar magnitude for both females and males. As the treatment progresses in the second half of the treatment, adapted expectations or other non-specific effects might play a more important role in predicting treatment outcome.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0268646","type":"journal-article","created":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T17:33:07Z","timestamp":1653067987000},"page":"e0268646","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Do patients\u2019 pre-treatment expectations about acupuncture effectiveness predict treatment outcome in patients with chronic low back pain? 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Ther"},{"issue":"1","key":"pone.0268646.ref042","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1026\/0943-8149.16.1.26","article-title":"The German version of the Life-Orientation-Test (LOT-R) for dispositional optimism and pessimism.","volume":"16","author":"H Glaesmer","year":"2008","journal-title":"Z Gesundheitspsychol."},{"key":"pone.0268646.ref043","unstructured":"Patient-Reported Outcomes Measurement Information System. 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Cohen","year":"1983","journal-title":"Appl Psychol Meas."},{"issue":"7549","key":"pone.0268646.ref053","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1136\/bmj.332.7549.1080","article-title":"The cost of dichotomising continuous variables","volume":"332","author":"DG Altman","year":"2006","journal-title":"BMJ"},{"issue":"8","key":"pone.0268646.ref054","first-page":"1022","article-title":"Reliability of pain scales in the assessment of literate and illiterate patients with rheumatoid arthritis","volume":"17","author":"MB Ferraz","year":"1990","journal-title":"J Rheumatol"},{"issue":"11","key":"pone.0268646.ref055","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1097\/AJP.0000000000000062","article-title":"Factors influencing further acupuncture usage and a more positive outcome in patients with osteoarthritis of the knee and the hip: A 3-year follow-up of a randomized pragmatic trial","volume":"30","author":"F Martins","year":"2014","journal-title":"Clin J Pain"},{"key":"pone.0268646.ref056","doi-asserted-by":"crossref","first-page":"125937","DOI":"10.1155\/2013\/125937","article-title":"Standardized versus individualized acupuncture for chronic low back pain: A randomized controlled trial","volume":"2013","author":"D Pach","year":"2013","journal-title":"Evid Based Complement Alternat Med"},{"issue":"30","key":"pone.0268646.ref057","doi-asserted-by":"crossref","DOI":"10.3310\/hta16300","article-title":"The measurement of patients\u2019 expectations for health care: a review and psychometric testing of a measure of patients\u2019 expectations.","volume":"16","author":"A Bowling","year":"2012","journal-title":"Health Technol Asses"},{"issue":"6","key":"pone.0268646.ref058","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.jpain.2016.01.477","article-title":"Overlap and differences between patient and provider Eexpectations for treatment outcomes: The case of acupuncture","volume":"17","author":"J Barth","year":"2016","journal-title":"J Pain"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0268646","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T17:34:13Z","timestamp":1653068053000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0268646"}},"subtitle":[],"editor":[{"given":"Yuanyuan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,5,20]]},"references-count":58,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,5,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0268646","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,20]]}}}