{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:42:49Z","timestamp":1790671369498,"version":"4.1.0"},"reference-count":18,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:00:00Z","timestamp":1664496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000295","name":"Epilepsy Research UK","doi-asserted-by":"crossref","award":["P1906"],"award-info":[{"award-number":["P1906"]}],"id":[{"id":"10.13039\/501100000295","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/T033150\/1"],"award-info":[{"award-number":["MR\/T033150\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"\n Objective<\/jats:title>\n Alternating Hemiplegia of Childhood (AHC) is characterised by paroxysmal hemiplegic episodes and seizures. Remission of hemiplegia upon sleep is a clinical diagnostic feature of AHC. We investigated whether: 1) Hemiplegic events are associated with spectral EEG changes 2) Sleep in AHC is associated with clinical or EEG spectral features that may explain its restorative effect.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We retrospectively performed EEG spectral analysis in five adults with AHC and twelve age-\/gender-matched epilepsy controls. Five-minute epochs of hemiplegic episodes and ten-minute epochs of four sleep stages were selected from video-EEGs. Arousals were counted per hour of sleep.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We found 1) hemispheric differences in pre-ictal and ictal spectral power (\n p<\/jats:italic>\n = 0.034), during AHC hemiplegic episodes 2) 22% reduced beta power (\n p<\/jats:italic>\n = 0.017) and 26% increased delta power (\n p<\/jats:italic>\n = 0.025) during wakefulness in AHC versus controls. There were 98% more arousals in the AHC group versus controls (\n p<\/jats:italic>\n = 0.0003).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n There are hemispheric differences in spectral power preceding hemiplegic episodes in adults with AHC, and sleep is disrupted.<\/jats:p>\n <\/jats:sec>\n \n Significance<\/jats:title>\n Spectral EEG changes may be a potential predictive tool for AHC hemiplegic episodes. Significantly disrupted sleep is a feature of AHC.<\/jats:p>\n <\/jats:sec>","DOI":"10.1371\/journal.pone.0268720","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T13:33:49Z","timestamp":1664544829000},"page":"e0268720","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Alternating hemiplegia of childhood: An electroclinical study of sleep and hemiplegia"],"prefix":"10.1371","volume":"17","author":[{"given":"Josephine","family":"Poole","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Zagaglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Demurtas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Farrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew C.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay M.","family":"Sisodiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Balestrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6116-2335","authenticated-orcid":true,"given":"Umesh","family":"Vivekananda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,9,30]]},"reference":[{"key":"pone.0268720.ref001","first-page":"5014","article-title":"Alternating hemiplegia of childhood in Denmark: Clinical manifestations and ATP1A3 mutation status","volume":"18","author":"CE Hoei-Hansen","year":"2014","journal-title":"European Journal of Paediatric Neurology"},{"key":"pone.0268720.ref002","doi-asserted-by":"crossref","first-page":"7777","DOI":"10.1111\/j.1469-8749.2007.00777.x","article-title":"The treatment and management of alternating hemiplegia of childhood","volume":"49","author":"B Neville","year":"2007","journal-title":"Developmental Medicine & Child Neurology"},{"key":"pone.0268720.ref003","first-page":"6733","article-title":"Goutitieurologyanagement of alternating hemipood","volume":"122","author":"M Bourgeois","year":"1993","journal-title":"The Journal of Pediatrics"},{"key":"pone.0268720.ref004","doi-asserted-by":"crossref","first-page":"e2866","DOI":"10.1212\/WNL.0000000000010794","article-title":"Cardiac phenotype in ATP1A3-related syndromes: A multicenter cohort study","volume":"95","author":"S Balestrini","year":"2020","journal-title":"Neurology"},{"key":"pone.0268720.ref005","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s13023-015-0335-5","article-title":"Clinical profile of patients with ATP1A3 mutations in Alternating Hemiplegia of Childhoodon status","volume":"10","author":"E Panagiotakaki","year":"2015","journal-title":"ing the complex Orphanet Journal of Rare Diseases"},{"key":"pone.0268720.ref006","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1212\/WNL.0000000000008159","article-title":"The epileptology of alternating hemiplegia of childhood","volume":"93","author":"J Uchitel","year":"2019","journal-title":"Neurology"},{"key":"pone.0268720.ref007","unstructured":"Aicardi J, Bourgeois M, Goutiti hemiplegia of childhood. ernating Hemiplegia of Childhoodon status. ing the complex pAlternating Hemiplegia of Childhood 1995;:3ing."},{"key":"pone.0268720.ref008","doi-asserted-by":"crossref","first-page":"6519","DOI":"10.5664\/jcsm.7572","article-title":"Polysomnography Findings and Sleep Disorders in Children With Alternating Hemiplegia of Childhood","volume":"15","author":"S Kansagra","year":"2019","journal-title":"Journal of Clinical Sleep Medicine"},{"key":"pone.0268720.ref009","doi-asserted-by":"crossref","first-page":"9404","DOI":"10.1016\/j.jneumeth.2003.10.009","article-title":"EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis","volume":"134","author":"A Delorme","year":"2004","journal-title":"Journal of Neuroscience Methods"},{"key":"pone.0268720.ref010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2011\/156869","article-title":"FieldTrip: Open Source Software for Advanced Analysis of MEG, EEG, and Invasive Electrophysiological Data","volume":"2011","author":"R Oostenveld","year":"2011","journal-title":"Computational Intelligence and Neuroscience"},{"key":"pone.0268720.ref011","article-title":"The AASM manual for the scoring of sleep and associated events. Rules, Terminology and Technical Specifications","author":"RB Berry","year":"2012","journal-title":"American Academy of Sleep Medicine"},{"key":"pone.0268720.ref012","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1111\/j.1469-8986.1966.tb02650.x","article-title":"THE FIRST NIGHT EFFECT: AN EEG STUDYOF SLEEP","volume":"2","author":"HW Agnew","year":"1966","journal-title":"Psychophysiology"},{"key":"pone.0268720.ref013","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1212\/WNL.57.8.1491","article-title":"Benign nocturnal alternating hemiplegia of childhood: Six patients and long-term follow-up","volume":"57","author":"V Chaves-Vischer","year":"2001","journal-title":"Neurology"},{"key":"pone.0268720.ref014","first-page":"5251","article-title":"Benign nocturnal alternating hemiplegia of childhood: Two cases with positive evolution","volume":"33","year":"2011","journal-title":"Brain and Development"},{"key":"pone.0268720.ref015","unstructured":"Brashear A, Sweadner KJ, Cook JF, et al. ATP1A3-Related Neurologic Disorders. GeneReviews 2008."},{"key":"pone.0268720.ref016","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1007\/s00415-020-09698-3","article-title":"White matter and cerebellar involvement in alternating hemiplegia of childhood","volume":"267","author":"M Severino","year":"2020","journal-title":"J Neurol"},{"key":"pone.0268720.ref017","first-page":"awab095","article-title":"Consciousness among delta waves: a paradox?","author":"J Frohlich","year":"2021","journal-title":"Brain"},{"key":"pone.0268720.ref018","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3389\/fneur.2020.00327","article-title":"Epilepsy and Its Interaction With Sleep and Circadian Rhythm","volume":"11","author":"B Jin","year":"2020","journal-title":"Frontiers in Neurology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0268720","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T13:34:09Z","timestamp":1664544849000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0268720"}},"subtitle":[],"editor":[{"given":"Dragan","family":"Hrncic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,9,30]]},"references-count":18,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,9,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0268720","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.05.14.22274850","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,30]]}}}