{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:34:19Z","timestamp":1788838459657,"version":"build-2803163510"},"reference-count":62,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T00:00:00Z","timestamp":1653350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"SGAIM Foundation"},{"DOI":"10.13039\/100008273","name":"Novartis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008273","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004362","name":"Schweizerische Herzstiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004362","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chuard Schmidt Foundation"},{"DOI":"10.13039\/501100005688","name":"Gottfried und Julia Bangerter-Rhyner-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005688","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Background<\/jats:title><jats:p>Hospital-acquired venous thromboembolism (VTE) is one of the leading preventable causes of in-hospital mortality. However, its risk assessment in medically ill inpatients is complicated due to the patients\u2019 heterogeneity and complexity of currently available risk assessment models (RAMs). The simplified Geneva score provides simplicity but has not yet been prospectively validated. Immobility is an important predictor for VTE in RAMs, but its definition is inconsistent and based on subjective assessment by nurses or physicians. In this study, we aim to prospectively validate the simplified Geneva score and to examine the predictive performance of a novel and objective definition of in-hospital immobilization using accelerometry.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Methods and analysis<\/jats:title><jats:p>RISE is a multicenter prospective cohort study. The goal is to recruit 1350 adult inpatients admitted for medical illness in three Swiss tertiary care hospitals. We collect data on demographics, comorbidities, VTE risk and thromboprophylaxis. Mobility from admission to discharge is objectively measured using a wrist-worn accelerometer. Participants are followed for 90 days for the occurrence of symptomatic VTE (primary outcome). Secondary outcomes are the occurrence of clinically relevant bleeding, and mortality. The evolution of autonomy in the activities of daily living, the length of stay, and the occurrence of readmission are also recorded. Time-dependent area under the curve, sensitivity, specificity, and positive and negative predictive values are calculated for each RAM (i.e. the simplified and original Geneva score, Padua, and IMPROVE score) with and without the objective mobility measures to assess their accuracy in predicting hospital-acquired VTE at 90 days.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Ethics and expected impact<\/jats:title><jats:p>The ethics committee approved the protocol and the study was registered on ClinicalTrials.gov as<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04439383\" xlink:type=\"simple\">NCT04439383<\/jats:ext-link>. RISE has the potential to optimize VTE risk stratification, and thus to improve the quality of care of medically hospitalized patients.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0268833","type":"journal-article","created":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T17:42:53Z","timestamp":1653414173000},"page":"e0268833","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Risk stratification for hospital-acquired venous thromboembolism in medical patients (RISE): Protocol for a prospective cohort study"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2698-9833","authenticated-orcid":true,"given":"Damien","family":"Choffat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline Darbellay","family":"Farhoumand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evrim","family":"Jaccard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2885-3799","authenticated-orcid":true,"given":"Roxane","family":"de la Harpe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6654-8154","authenticated-orcid":true,"given":"Vanessa","family":"Kraege","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1870-9109","authenticated-orcid":true,"given":"Malik","family":"Benmachiche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christel","family":"Gerber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salom\u00e9","family":"Leuzinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2452-8067","authenticated-orcid":true,"given":"Clara","family":"Podmore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1177-0815","authenticated-orcid":true,"given":"Minh Khoa","family":"Truong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Dumans-Louis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Marti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Reny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drahomir","family":"Aujesky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damiana","family":"Rakovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Limacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5803-3233","authenticated-orcid":true,"given":"Jean-Beno\u00eet","family":"Rossel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Baumgartner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"M\u00e9an","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,5,24]]},"reference":[{"key":"pone.0268833.ref001","author":"G. Maynard","year":"2016","edition":"2"},{"issue":"6","key":"pone.0268833.ref002","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1378\/chest.118.6.1680","article-title":"New onset of venous thromboembolism among hospitalized patients at Brigham and Women\u2019s Hospital is caused more often by prophylaxis failure than by withholding treatment.","volume":"118","author":"SZ Goldhaber","year":"2000","journal-title":"Chest"},{"issue":"6","key":"pone.0268833.ref003","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1001\/archinte.160.6.809","article-title":"Risk factors for deep vein thrombosis and pulmonary embolism: a population-based case-control study","volume":"160","author":"JA Heit","year":"2000","journal-title":"Arch Intern Med"},{"issue":"5","key":"pone.0268833.ref004","first-page":"CD003747","article-title":"Heparin for the prevention of venous thromboembolism in acutely ill medical patients (excluding stroke and myocardial infarction).","author":"R Alikhan","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"issue":"26","key":"pone.0268833.ref005","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1056\/NEJMoa1111288","article-title":"Low-molecular-weight heparin and mortality in acutely ill medical patients","volume":"365","author":"AK Kakkar","year":"2011","journal-title":"The New England journal of medicine"},{"issue":"11","key":"pone.0268833.ref006","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1056\/NEJM199909093411103","article-title":"A comparison of enoxaparin with placebo for the prevention of venous thromboembolism in acutely ill medical patients. Prophylaxis in Medical Patients with Enoxaparin Study Group","volume":"341","author":"MM Samama","year":"1999","journal-title":"The New England journal of medicine"},{"issue":"2","key":"pone.0268833.ref007","doi-asserted-by":"crossref","first-page":"e195S","DOI":"10.1378\/chest.11-2296","article-title":"Prevention of VTE in nonsurgical patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines","volume":"141","author":"SR Kahn","year":"2012","journal-title":"Chest"},{"issue":"22","key":"pone.0268833.ref008","doi-asserted-by":"crossref","first-page":"3198","DOI":"10.1182\/bloodadvances.2018022954","article-title":"American Society of Hematology 2018 guidelines for management of venous thromboembolism: prophylaxis for hospitalized and nonhospitalized medical patients","volume":"2","author":"HJ Schunemann","year":"2018","journal-title":"Blood Adv"},{"issue":"3","key":"pone.0268833.ref009","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1160\/TH13-05-0427","article-title":"Multicentre validation of the Geneva Risk Score for hospitalised medical patients at risk of venous thromboembolism. Explicit ASsessment of Thromboembolic RIsk and Prophylaxis for Medical PATients in SwitzErland (ESTIMATE).","volume":"111","author":"M Nendaz","year":"2014","journal-title":"Thromb Haemost"},{"issue":"11","key":"pone.0268833.ref010","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1111\/j.1538-7836.2010.04044.x","article-title":"A risk assessment model for the identification of hospitalized medical patients at risk for venous thromboembolism: the Padua Prediction Score","volume":"8","author":"S Barbar","year":"2010","journal-title":"J Thromb Haemost"},{"issue":"3","key":"pone.0268833.ref011","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1378\/chest.10-1944","article-title":"Predictive and associative models to identify hospitalized medical patients at risk for VTE","volume":"140","author":"AC Spyropoulos","year":"2011","journal-title":"Chest"},{"issue":"3","key":"pone.0268833.ref012","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1378\/chest.10-1944","article-title":"Predictive and associative models to identify hospitalized medical patients at risk for VTE","volume":"140","author":"AC Spyropoulos","year":"2011","journal-title":"Chest"},{"issue":"1","key":"pone.0268833.ref013","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1160\/TH17-06-0403","article-title":"Comparative Performance of Clinical Risk Assessment Models for Hospital-Acquired Venous Thromboembolism in Medical Patients","volume":"118","author":"M Blondon","year":"2018","journal-title":"Thromb Haemost"},{"issue":"6","key":"pone.0268833.ref014","doi-asserted-by":"crossref","first-page":"e001152","DOI":"10.1161\/JAHA.114.001152","article-title":"External validation of the risk assessment model of the International Medical Prevention Registry on Venous Thromboembolism (IMPROVE) for medical patients in a tertiary health system","volume":"3","author":"D Rosenberg","year":"2014","journal-title":"Journal of the American Heart Association"},{"issue":"3","key":"pone.0268833.ref015","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1177\/1076029612452781","article-title":"Relevance of immobility and importance of risk assessment management for medically ill patients","volume":"19","author":"RD Hull","year":"2013","journal-title":"Clinical and applied thrombosis\/hemostasis: official journal of the International Academy of Clinical and Applied Thrombosis\/Hemostasis"},{"issue":"8","key":"pone.0268833.ref016","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1111\/j.1532-5415.2004.52354.x","article-title":"Prevalence and outcomes of low mobility in hospitalized older patients","volume":"52","author":"CJ Brown","year":"2004","journal-title":"Journal of the American Geriatrics Society"},{"issue":"4","key":"pone.0268833.ref017","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.gerinurse.2004.06.016","article-title":"Frequency of hallway ambulation by hospitalized older adults on medical units of an academic hospital","volume":"25","author":"BL Callen","year":"2004","journal-title":"Geriatric nursing"},{"issue":"12","key":"pone.0268833.ref018","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1001\/archinte.1991.00400120090017","article-title":"The provision of physical activity to hospitalized elderly patients","volume":"151","author":"BA Lazarus","year":"1991","journal-title":"Arch Intern Med"},{"issue":"1","key":"pone.0268833.ref019","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1001\/jamainternmed.2018.5145","article-title":"Routine Inpatient Mobility Assessment and Hospital Discharge Planning.","volume":"179","author":"EH Hoyer","year":"2019","journal-title":"JAMA internal medicine"},{"issue":"4","key":"pone.0268833.ref020","doi-asserted-by":"crossref","first-page":"220","DOI":"10.14423\/SMJ.0000000000000788","article-title":"Measuring Functional Status in Hospitalized Older Adults Through Electronic Health Record Documentation.","volume":"111","author":"L Sinvani","year":"2018","journal-title":"Southern medical journal"},{"issue":"2","key":"pone.0268833.ref021","doi-asserted-by":"crossref","first-page":"e187673","DOI":"10.1001\/jamanetworkopen.2018.7673","article-title":"Association of Wearable Activity Monitors With Assessment of Daily Ambulation and Length of Stay Among Patients Undergoing Major Surgery.","volume":"2","author":"TJ Daskivich","year":"2019","journal-title":"JAMA network open"},{"issue":"4","key":"pone.0268833.ref022","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1682\/JRRD.2007.06.0086","article-title":"Validation of use of wireless monitors to measure levels of mobility during hospitalization","volume":"45","author":"CJ Brown","year":"2008","journal-title":"Journal of rehabilitation research and development"},{"key":"pone.0268833.ref023","doi-asserted-by":"crossref","first-page":"3280240","DOI":"10.1155\/2018\/3280240","article-title":"Using Accelerometers to Measure Physical Activity in Older Patients Admitted to Hospital.","volume":"2018","author":"P Hartley","year":"2018","journal-title":"Current gerontology and geriatrics research"},{"issue":"11","key":"pone.0268833.ref024","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1007\/s40520-018-0930-0","article-title":"Physical activity among hospitalised older people: insights from upper and lower limb accelerometry","volume":"30","author":"SER Lim","year":"2018","journal-title":"Aging clinical and experimental research."},{"issue":"6","key":"pone.0268833.ref025","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1249\/MSS.0000000000000224","article-title":"Assessing sedentary behavior with the GENEActiv: introducing the sedentary sphere.","volume":"46","author":"AV Rowlands","year":"2014","journal-title":"Medicine and science in sports and exercise"},{"issue":"3","key":"pone.0268833.ref026","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s12603-017-0931-2","article-title":"Assessment of Physical Activity of Hospitalised Older Adults: A Systematic Review","volume":"22","author":"SER Lim","year":"2018","journal-title":"The journal of nutrition, health & aging"},{"issue":"9","key":"pone.0268833.ref027","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1001\/archinte.164.9.963","article-title":"Risk factors for venous thromboembolism in hospitalized patients with acute medical illness: analysis of the MEDENOX Study","volume":"164","author":"R Alikhan","year":"2004","journal-title":"Arch Intern Med"},{"issue":"13","key":"pone.0268833.ref028","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1161\/CIRCULATIONAHA.107.726232","article-title":"Clinical predictors for fatal pulmonary embolism in 15,520 patients with venous thromboembolism: findings from the Registro Informatizado de la Enfermedad TromboEmbolica venosa (RIETE) Registry.","volume":"117","author":"S Laporte","year":"2008","journal-title":"Circulation"},{"issue":"5","key":"pone.0268833.ref029","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: development and validation.","volume":"40","author":"ME Charlson","year":"1987","journal-title":"Journal of chronic diseases"},{"issue":"6","key":"pone.0268833.ref030","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1093\/aje\/kwq433","article-title":"Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries","volume":"173","author":"H Quan","year":"2011","journal-title":"American journal of epidemiology"},{"issue":"12","key":"pone.0268833.ref031","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1056\/NEJMoa1805090","article-title":"Rivaroxaban for Thromboprophylaxis after Hospitalization for Medical Illness","volume":"379","author":"AC Spyropoulos","year":"2018","journal-title":"The New England journal of medicine"},{"issue":"1","key":"pone.0268833.ref032","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1378\/chest.09-3081","article-title":"Factors at admission associated with bleeding risk in medical patients: findings from the IMPROVE investigators","volume":"139","author":"H Decousus","year":"2011","journal-title":"Chest"},{"issue":"2","key":"pone.0268833.ref033","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1378\/chest.14-2842","article-title":"Validation of the International Medical Prevention Registry on Venous Thromboembolism Bleeding Risk Score","volume":"149","author":"DC Hostler","year":"2016","journal-title":"Chest"},{"issue":"8","key":"pone.0268833.ref034","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/0895-4356(89)90065-6","article-title":"Improving the sensitivity of the Barthel Index for stroke rehabilitation","volume":"42","author":"S Shah","year":"1989","journal-title":"Journal of clinical epidemiology"},{"issue":"10","key":"pone.0268833.ref035","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1249\/MSS.0000000000000978","article-title":"Raw accelerometer data analysis with GGIR R-package: does accelerometer brand matter","volume":"48","author":"AV Rowlands","year":"2016","journal-title":"Medicine and science in sports and exercise"},{"issue":"5","key":"pone.0268833.ref036","doi-asserted-by":"crossref","first-page":"e0109913","DOI":"10.1371\/journal.pone.0109913","article-title":"Number of Days Required to Estimate Habitual Activity Using Wrist-Worn GENEActiv Accelerometer: A Cross-Sectional Study","volume":"11","author":"CB Dillon","year":"2016","journal-title":"PloS one"},{"issue":"1","key":"pone.0268833.ref037","doi-asserted-by":"crossref","first-page":"e1920185","DOI":"10.1001\/jamanetworkopen.2019.20185","article-title":"Association Between Physical Activity Levels in the Hospital Setting and Hospital-Acquired Functional Decline in Elderly Patients","volume":"3","author":"P Tasheva","year":"2020","journal-title":"JAMA Network Open"},{"issue":"4","key":"pone.0268833.ref038","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/00006199-198707000-00002","article-title":"The Braden Scale for Predicting Pressure Sore Risk","volume":"36","author":"N Bergstrom","year":"1987","journal-title":"Nurs Res"},{"issue":"11","key":"pone.0268833.ref039","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1056\/NEJMoa064247","article-title":"Idraparinux versus standard therapy for venous thromboembolic disease","volume":"357","author":"HR Buller","year":"2007","journal-title":"The New England journal of medicine"},{"issue":"11","key":"pone.0268833.ref040","doi-asserted-by":"crossref","first-page":"e040151","DOI":"10.1136\/bmjopen-2020-040151","article-title":"Clinical Surveillance vs. Anticoagulation For low-risk patiEnts with isolated SubSegmental Pulmonary Embolism: protocol for a multicentre randomised placebo-controlled non-inferiority trial (SAFE-SSPE).","volume":"10","author":"C Baumgartner","year":"2020","journal-title":"BMJ Open"},{"issue":"10","key":"pone.0268833.ref041","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1056\/NEJM199709043371001","article-title":"Low-Molecular-Weight Heparin in the Treatment of Patients with Venous Thromboembolism.","volume":"337","author":"TC Investigators","year":"1997","journal-title":"New England Journal of Medicine"},{"issue":"1","key":"pone.0268833.ref042","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jvsv.2016.08.002","article-title":"Analysis of noncatheter-associated upper extremity deep venous thrombosis from the RIETE registry","volume":"5","author":"DH Newton","year":"2017","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"issue":"4","key":"pone.0268833.ref043","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s11239-013-0875-2","article-title":"The Swiss cohort of elderly patients with venous thromboembolism (SWITCO65+): rationale and methodology","volume":"36","author":"M Mean","year":"2013","journal-title":"Journal of thrombosis and thrombolysis"},{"issue":"6","key":"pone.0268833.ref044","doi-asserted-by":"crossref","first-page":"e18996","DOI":"10.1097\/MD.0000000000018996","article-title":"A STROBE cohort study of 755 deep and superficial upper-extremity vein thrombosis","volume":"99","author":"G Ploton","year":"2020","journal-title":"Medicine"},{"issue":"5","key":"pone.0268833.ref045","doi-asserted-by":"crossref","first-page":"e0154832","DOI":"10.1371\/journal.pone.0154832","article-title":"Multifaceted Intervention to Prevent Venous Thromboembolism in Patients Hospitalized for Acute Medical Illness: A Multicenter Cluster-Randomized Trial","volume":"11","author":"PM Roy","year":"2016","journal-title":"PloS one"},{"issue":"7","key":"pone.0268833.ref046","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1177\/1076029616663847","article-title":"Comparisons Between Upper and Lower Extremity Deep Vein Thrombosis: A Review of the RIETE Registry.","volume":"23","author":"LP Cote","year":"2017","journal-title":"Clinical and applied thrombosis\/hemostasis: official journal of the International Academy of Clinical and Applied Thrombosis\/Hemostasis"},{"key":"pone.0268833.ref047","article-title":"Comparison of Bleeding Risk Scores in Elderly Patients Receiving Extended Anticoagulation with Vitamin K Antagonists for Venous Thromboembolism","author":"AN Frei","year":"2021","journal-title":"Thromb Haemost. (EFirst)."},{"issue":"4","key":"pone.0268833.ref048","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/j.1538-7836.2005.01204.x","article-title":"Subcommittee on Control of Anticoagulation of the S, Standardization Committee of the International Society on T, Haemostasis. Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients","volume":"3","author":"S Schulman","year":"2005","journal-title":"J Thromb Haemost"},{"issue":"6","key":"pone.0268833.ref049","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1160\/TH15-09-0756","article-title":"The MARINER trial of rivaroxaban after hospital discharge for medical patients at high risk of VTE. Design, rationale, and clinical implications","volume":"115","author":"GE Raskob","year":"2016","journal-title":"Thromb Haemost"},{"issue":"6","key":"pone.0268833.ref050","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1111\/jth.14769","article-title":"Definition of pulmonary embolism-related death and classification of the cause of death in venous thromboembolism studies: Communication from the SSC of the ISTH","volume":"18","author":"T Tritschler","year":"2020","journal-title":"J Thromb Haemost"},{"key":"pone.0268833.ref051","article-title":"Development of a standardized definition of pulmonary embolism-related death: a cross-sectional survey of international thrombosis experts","author":"T Tritschler","year":"2020","journal-title":"J Thromb Haemost"},{"issue":"17","key":"pone.0268833.ref052","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1161\/CIRCULATIONAHA.106.685313","article-title":"Clinical End Points in Coronary Stent Trials","volume":"115","author":"DE Cutlip","year":"2007","journal-title":"Circulation"},{"key":"pone.0268833.ref053","article-title":"Manual of the international statistical classification of diseases, injury, and causes of death","author":"World Health Organization","year":"1977"},{"issue":"3","key":"pone.0268833.ref054","doi-asserted-by":"crossref","first-page":"200","DOI":"10.7326\/0003-4819-158-3-201302050-00583","volume":"158","author":"SPIRIT 2013 Statement: Defining Standard Protocol Items for Clinical Trials","year":"2013","journal-title":"Annals of Internal Medicine"},{"issue":"446","key":"pone.0268833.ref055","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1080\/01621459.1999.10474144","article-title":"A Proportional Hazards Model for the Subdistribution of a Competing Risk","volume":"94","author":"JP Fine","year":"1999","journal-title":"Journal of the American Statistical Association"},{"issue":"9610","key":"pone.0268833.ref056","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0140-6736(08)60202-0","article-title":"Venous thromboembolism risk and prophylaxis in the acute hospital care setting (ENDORSE study): a multinational cross-sectional study","volume":"371","author":"AT Cohen","year":"2008","journal-title":"Lancet (London, England)."},{"issue":"5","key":"pone.0268833.ref057","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1160\/TH14-06-0525","article-title":"Predictors of thromboprophylaxis in hospitalised medical patients. Explicit ASsessment of Thromboembolic RIsk and Prophylaxis for Medical PATients in SwitzErland (ESTIMATE).","volume":"113","author":"D Spirk","year":"2015","journal-title":"Thromb Haemost"},{"issue":"6","key":"pone.0268833.ref058","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1111\/jep.12569","article-title":"Thromboprophylaxis adherence to the ninth edition of American college of chest physicians antithrombotic guidelines in a tertiary care centre: a cross-sectional study","volume":"22","author":"T Theriault","year":"2016","journal-title":"Journal of evaluation in clinical practice"},{"issue":"2","key":"pone.0268833.ref059","doi-asserted-by":"crossref","first-page":"e200064","DOI":"10.1001\/jamanetworkopen.2020.0064","article-title":"Effect of a Physiotherapist-Guided Home-Based Exercise Intervention on Physical Capacity and Patient-Reported Outcomes Among Patients With Acute Pulmonary Embolism: A Randomized Clinical Trial","volume":"3","author":"N Rolving","year":"2020","journal-title":"JAMA Network Open"},{"issue":"2","key":"pone.0268833.ref060","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1123\/japa.2018-0462","article-title":"Physical Activity in the Hospital: Documentation and Influence on Venous Thromboembolism Prophylaxis","volume":"28","author":"JM Pavon","year":"2020","journal-title":"Journal of Aging and Physical Activity"},{"issue":"12","key":"pone.0268833.ref061","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1136\/thx.47.12.1019","article-title":"Development of a shuttle walking test of disability in patients with chronic airways obstruction","volume":"47","author":"SJ Singh","year":"1992","journal-title":"Thorax"},{"issue":"5","key":"pone.0268833.ref062","doi-asserted-by":"crossref","first-page":"272","DOI":"10.12788\/jhm.3153","article-title":"Increasing Mobility via In-hospital Ambulation Protocol Delivered by Mobility Technicians: A Pilot Randomized Controlled Trial","volume":"14","author":"AC Hamilton","year":"2019","journal-title":"J Hosp Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0268833","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T04:33:19Z","timestamp":1700627599000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0268833"}},"subtitle":[],"editor":[{"given":"Roza","family":"Chaireti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,5,24]]},"references-count":62,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,5,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0268833","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,24]]}}}