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In attempts for finding therapeutic treatment for the new disease, this work has focused on examining the polymerase inhibitors against the SARS-CoV-2 nsp12 and co-factors nsp8 and nsp7. Several polymerase inhibitors were examined against PDB ID: 6M71 using computational analysis evaluating the ligand\u2019s binding affinity to replicating groove to the active site. The findings of this analysis showed Cytarabine of -5.65 Kcal\/mol with the highest binding probability (70%) to replicating groove of 6M71. The complex stability was then examined over 19 ns molecular dynamics simulation suggesting that Cytarabine might be possible potent inhibitor for the SARS-CoV-2 RNA Dependent RNA Polymerase.<\/jats:p>","DOI":"10.1371\/journal.pone.0268909","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T17:29:53Z","timestamp":1654018193000},"page":"e0268909","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Seeking antiviral drugs to inhibit SARS-CoV-2 RNA dependent RNA polymerase: A molecular docking analysis"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7463-0000","authenticated-orcid":true,"given":"Ibrahim","family":"Khater","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5542-9387","authenticated-orcid":true,"given":"Aaya","family":"Nassar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,5,31]]},"reference":[{"key":"pone.0268909.ref001","first-page":"1","volume":"77","author":"C Acuti","year":"2020","journal-title":"Advances in Biological Regulation SARS-CoV-2 pandemic: An overview."},{"key":"pone.0268909.ref002","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S1471-4914(03)00133-3","article-title":"Severe acute respiratory syndrome: identification of the etiological agent","volume":"9","author":"C Drosten","year":"2003","journal-title":"Trends Mol Med"},{"key":"pone.0268909.ref003","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.bbrc.2018.02.136","article-title":"Structural characterization of the HCoV-229E fusion core","volume":"497","author":"W Zhang","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"pone.0268909.ref004","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.3390\/v4061011","article-title":"Mechanisms of coronavirus cell entry mediated by the viral spike protein","volume":"4","author":"S Belouzard","year":"2012","journal-title":"Viruses"},{"key":"pone.0268909.ref005","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1097\/CCM.0b013e3181ceb25b","article-title":"The 1918 influenza pandemic: lessons for 2009 and the future.","volume":"38","author":"DM Morens","year":"2010","journal-title":"Crit Care Med"},{"key":"pone.0268909.ref006","first-page":"187","article-title":"Understanding the Influenza A H1N1 2009 Pandemic.","volume":"10","author":"Z. 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