{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T07:22:07Z","timestamp":1769152927636,"version":"3.49.0"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"\nObjective<\/jats:title>\nTo analyze the characteristics associated with vaccination against Covid-19 in pregnant and postpartum women with Severe Acute Respiratory Syndrome in Brazil and to investigate a possible association between vaccination and the clinical course and outcome of the disease.<\/jats:p>\n<\/jats:sec>\n\nMethods<\/jats:title>\nRetrospective cohort study of hospitalized pregnant and postpartum women diagnosed with Severe Acute Respiratory Syndrome (SARS) by SARS-CoV-2, presenting onset of signs and symptoms between May and October 2021. Secondary data were used, available in the Influenza Epidemiological Surveillance Information System (SIVEP-Gripe). Data were analyzed using the SPSS statistical program, medians were applied to present continuous variables and frequencies, and proportions were calculated for categorical variables, using logistic and multivariate regression analysis.<\/jats:p>\n<\/jats:sec>\n\nResults<\/jats:title>\nThe final study population included 3,585 pregnant and postpartum women, of whom 596 (16.6) were vaccinated: 443 (74.3%) received one dose and 153 (25.7%) received two doses. They were factors associated with non-vaccination against Covid-19 age \u2264 19 anos (OR: 2.57; IC95%<\/jats:sub> 1.40;4.71), non-white women (OR: 1.34; IC95%<\/jats:sub> 1.07;1.67) and those who required ventilatory support (OR: 1.51; IC95%<\/jats:sub> 1.19;1.90) and invasive ventilation (OR: 2.05; IC95%<\/jats:sub> 1.37;3.08). On the other hand, vaccination was associated with advanced maternal age (OR: 0.60; IC95%<\/jats:sub> 0.48;0.76), presence of comorbidities (OR: 0.57; IC95%<\/jats:sub> 0.45;0.72) and loss of taste (OR: 0.63; IC95%<\/jats:sub> 0.48;0.82).<\/jats:p>\n<\/jats:sec>\n\nConclusions<\/jats:title>\nDemographic, ethnic-racial and clinical characteristics were associated with the vaccination status of pregnant and postpartum women with SARS by SARS-CoV-2 in Brazil. Vaccination against Covid-19 in the obstetric population has already shown positive results in the evolution of severe cases, which reiterates its importance. It is essential that health services advance vaccination against Covid-19 in the obstetric population, especially adolescentes and non-white women.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0269091","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T17:52:52Z","timestamp":1655315572000},"page":"e0269091","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Factors associated with vaccination against Covid-19 in pregnant and hospitalized postpartum women: A retrospective cohort study"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2091-5975","authenticated-orcid":true,"given":"Marcela","family":"de Andrade Pereira Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena Fiats","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosana Rosseto de","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6233-3968","authenticated-orcid":true,"given":"Fernando Castilho","family":"Pelloso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constanza","family":"Pujals","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ra\u00edssa Bocchi","family":"Pedroso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Dalva de Barros","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra Marisa","family":"Pelloso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2022,6,15]]},"reference":[{"key":"pone.0269091.ref001","unstructured":"World Health Organization. WHO Director-General\u2019s opening remarks at the media briefing on COVID-19\u201311 March 2020. Geneva (CH): WHO; 2020. [cited 16 Apr 2021]. https:\/\/www.who.int\/docs\/default-source\/coronaviruse\/transcripts\/who-audio-emergencies-coronavirus-press-conference-full-and-final-11mar2020.pdf"},{"key":"pone.0269091.ref002","unstructured":"World Health Organization. WHO Coronavirus (COVID-19) Dashboard. Geneva (CH) WHO; 2021. [cited 20 Apr 2021] https:\/\/covid19.who.int\/"},{"issue":"44","key":"pone.0269091.ref003","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.15585\/mmwr.mm6944e3","article-title":"Update: Characteristics of Symptomatic Women of Reproductive Age with Laboratory-Confirmed SARS-CoV-2 Infection by Pregnancy Status\u2014United States, January 22\u2013October 3, 2020","volume":"69","author":"LD Zambrano","year":"2020","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"pone.0269091.ref004","doi-asserted-by":"crossref","first-page":"m3320","DOI":"10.1136\/bmj.m3320","article-title":"Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis","volume":"370","author":"J Allotey","year":"2020","journal-title":"BMJ"},{"key":"pone.0269091.ref005","unstructured":"Minist\u00e9rio da Sa\u00fade (BR). Funda\u00e7\u00e3o Osvaldo Cruz. Boletim observat\u00f3rio Covid-19. Semanas epidemiol\u00f3gicas 20 e 21. Bras\u00edlia, DF; 2021 [cited 20 May 2021] https:\/\/agencia.fiocruz.br\/sites\/agencia.fiocruz.br\/files\/u34\/boletim_covid_2021-semanas_20-21-red.pdf"},{"key":"pone.0269091.ref006","first-page":"43","article-title":"Vaccines for COVID-19: the current state of play","volume":"35","author":"A Koirala","year":"2020","journal-title":"Paediatr Respir Rev"},{"key":"pone.0269091.ref007","unstructured":"World Health Organization. WHO Coronavirus Disease (COVID-19) Vaccines. Geneva (CH): WHO; 2021 [cited 06 Jun 2021] https:\/\/extranet.who.int\/pqweb\/vaccines\/covid-19-vaccines"},{"key":"pone.0269091.ref008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/14767058.2021.1937991","article-title":"COVID-19 vaccination in pregnancy and postpartum","author":"E Brillo","year":"2021","journal-title":"J Mater Fetal Neonatal Med"},{"issue":"24","key":"pone.0269091.ref009","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1056\/NEJMoa2104983","article-title":"Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons","volume":"384","author":"TT Shimabukuro","year":"2021","journal-title":"N Engl J Med"},{"key":"pone.0269091.ref010","unstructured":"The American College of Obstetricians and Gynecologists (ACOG). COVID-19 Vaccines and Pregnancy: Key recommendations and Messaging for Clinicians. 2021 [cited 02 Oct 2021] https:\/\/www.acog.org\/covid-19\/covid-19-vaccines-and-pregnancy-conversation-guide-for-clinicians"},{"key":"pone.0269091.ref011","unstructured":"Centers for Disease Control and Prevention (US). Vaccination Considerations for People who are Pregnant or Breastfeeding. 2021 [cited 02 Oct 2021] https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/vaccines\/recommendations\/pregnancy.html"},{"key":"pone.0269091.ref012","unstructured":"International Federation of Gynecology and Obstetrics (FIGO). COVID-19 Vaccination for Pregnant and Breastfeeding Women. 2021 [cited 03 Oct 2021] https:\/\/www.figo.org\/covid-19-vaccination-pregnant-and-breastfeeding-women"},{"key":"pone.0269091.ref013","unstructured":"Minist\u00e9rio da Sa\u00fade (BR). Plano Nacional de Operacionaliza\u00e7\u00e3o da vacina\u00e7\u00e3o contra a covid-19. 6a edi\u00e7\u00e3o. Bras\u00edlia: Minist\u00e9rio da Sa\u00fade, 2021 [cited 10 Oct 2021] https:\/\/www.conasems.org.br\/wp-content\/uploads\/2021\/04\/6a-Edic%CC%A7a%CC%83o-Plano-Vacinac%CC%A7a%CC%83o-contra-Covid_V5_27abr-21.pdf"},{"key":"pone.0269091.ref014","unstructured":"Minist\u00e9rio da Sa\u00fade (BR). Guia de vigil\u00e2ncia epidemiol\u00f3gica. Emerg\u00eancia de sa\u00fade p\u00fablica de import\u00e2ncia nacional pela doen\u00e7a pelo coronav\u00edrus 2019. Bras\u00edlia: Minist\u00e9rio da Sa\u00fade, 2020 [cited 20 Oct 2021] https:\/\/portalarquivos.saude.gov.br\/images\/af_gvs_coronavirus_6ago20_ajustes-finais-2.pdf"},{"key":"pone.0269091.ref015","unstructured":"Minist\u00e9rio da Sa\u00fade (BR). Portaria n\u00b0. 1.119, de 5 de Junho de 2008. Regulamenta a vigil\u00e2ncia de \u00f3bitos maternos. Di\u00e1rio Oficial da Uni\u00e3o de 2008. [cited 21 Mar 2021] https:\/\/bvsms.saude.gov.br\/bvs\/saudelegis\/gm\/2008\/prt1119_05_06_2008.html"},{"key":"pone.0269091.ref016","unstructured":"Conselho Nacional de Sa\u00fade (BR). Resolu\u00e7\u00e3o n\u00b0. 510, de 7 de Abril de 2016. Disp\u00f5e sobre as normas aplic\u00e1veis a pesquisas em Ci\u00eancias Humanas e Sociais [cited 01 Apr 2021] http:\/\/conselho.saude.gov.br\/resolucoes\/2016\/Reso510.pdf"},{"key":"pone.0269091.ref017","unstructured":"Minist\u00e9rio da Sa\u00fade (BR). Plano Nacional de Operacionaliza\u00e7\u00e3o da vacina\u00e7\u00e3o contra a covid-19. 1a edi\u00e7\u00e3o. Bras\u00edlia: Minist\u00e9rio da Sa\u00fade, 2020 [cited 01 Apr 2021] https:\/\/www.conasems.org.br\/wp-content\/uploads\/2021\/04\/1a-Edic%CC%A7a%CC%83o-Plano-Nacional-de-Vacinac%CC%A7a%CC%83o-contra-Covid_V1_16dez20.pdf"},{"key":"pone.0269091.ref018","unstructured":"Minist\u00e9rio da Sa\u00fade (BR). Plano Nacional de Operacionaliza\u00e7\u00e3o da vacina\u00e7\u00e3o contra a covid-19. 2a edi\u00e7\u00e3o. Bras\u00edlia: Minist\u00e9rio da Sa\u00fade, 2021 [cited 01 Apr 2021] https:\/\/www.conasems.org.br\/wp-content\/uploads\/2021\/04\/2a-Edic%CC%A7a%CC%83o-Plano-Vacinac%CC%A7a%CC%83o-contra-Covid_v2_25jan21.pdf"},{"key":"pone.0269091.ref019","unstructured":"Minist\u00e9rio da Sa\u00fade (BR). Secretaria de Vigil\u00e2ncia em Sa\u00fade. Departamento de Imuniza\u00e7\u00e3o e Doen\u00e7as Transmiss\u00edveis. Coordena\u00e7\u00e3o-Geral do Programa Nacional de Imuniza\u00e7\u00f5es. Nota t\u00e9cnica n\u00b0. 651\/2021-CGPNI\/DEIDT\/SVS\/MS. [cited 01 Apr 2021]"},{"issue":"3","key":"pone.0269091.ref020","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/ijgo.13407","article-title":"Risk factors for adverse outcomes among pregnant and postpartum women with acute respiratory distress syndrome due to COVID-19 in Brazil","volume":"151","author":"MO Menezes","year":"2020","journal-title":"International Journal of Gynecology & Obstetrics"},{"key":"pone.0269091.ref021","unstructured":"Minist\u00e9rio da Sa\u00fade (BR). Secretaria Extraordin\u00e1ria de Enfrentamento \u00e0 COVID-19. Nota T\u00e9cnicaa n\u00b0 45\/2021-SECOVID\/GAB\/SECOVID\/MS. Bras\u00edlia: Minist\u00e9rio da Sa\u00fade, 2021 [cited 28 Sep 2021] https:\/\/sbim.org.br\/images\/files\/notas-tecnicas\/sei-ms-secovid-libera-vacinacao-adolescentes-210922.pdf"},{"issue":"342","key":"pone.0269091.ref022","first-page":"1","article-title":"Impact of aging on obstetric outcomes: defining advanced maternal age in Barcelona","volume":"19","author":"MC Nieto","year":"2019","journal-title":"BMC Pregnancy and Childbirth"},{"issue":"3","key":"pone.0269091.ref023","first-page":"1","article-title":"Desigualdades raciais em sa\u00fade e a pandemia da Covid-19","volume":"18","author":"EF Goes","year":"2020","journal-title":"Trab Educ Sa\u00fade"},{"key":"pone.0269091.ref024","first-page":"100917","article-title":"COVID-19 poses alarming pregnancy and postpartum mortality risk in Brazil","volume":"36","author":"S Gurzenda","year":"2021","journal-title":"E Clinical Medicine"},{"issue":"33","key":"pone.0269091.ref025","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.15585\/mmwr.mm6933e1","article-title":"Disparities in Incidence of COVID-19 Among Underrepresented Racial\/Ethnic Groups in Counties Identified as Hotspots During June 5\u201318, 2020\u201322 States, February\u2013June 2020","volume":"69","author":"JT Moore","year":"2020","journal-title":"MMWR Morbidity and Mortality Weekly Report"},{"issue":"11","key":"pone.0269091.ref026","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1093\/cid\/ciaa1066","article-title":"Disproportionate impact of Coronavirus Disease 2019 (COVID-19) among pregnant and postpartum Black Women in Brazil through structural racism lens","volume":"72","author":"DS Santos","year":"2020","journal-title":"Clin Infect Dis"},{"key":"pone.0269091.ref027","article-title":"The Relationship Between Social Determinants of Health and Racial Disparities in COVID-19 Mortality","author":"AK Dalsania","year":"2021","journal-title":"J Racial Ethn Health Disparities"},{"issue":"3","key":"pone.0269091.ref028","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/ijgo.13804","article-title":"Mortality in pregnancy and the postpartum period in women with severe acute respiratory distress syndrome related to COVID-19 in Brazil, 2020","volume":"155","author":"CA Scheler","year":"2021","journal-title":"Int J Gynaecol Obstet"},{"issue":"1","key":"pone.0269091.ref029","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1590\/1806-9282.67.01.20200633","article-title":"Race inequalities in maternal mortality in the city of Rio de Janeiro, Brazil: 2010\u20132019","volume":"67","author":"LGR Alves","year":"2021","journal-title":"Rev Assoc Med Bras"},{"issue":"4","key":"pone.0269091.ref030","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1007\/s11524-021-00551-0","article-title":"Vaccination Disparity: Quantifying Racial Inequity in COVID-19 Vaccine Administration in Maryland","volume":"98","author":"S Cardona","year":"2021","journal-title":"Journal of Urban Health"},{"key":"pone.0269091.ref031","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"C Huang","year":"2020","journal-title":"The Lancet"},{"issue":"Supl 2","key":"pone.0269091.ref032","first-page":"471","article-title":"S\u00edndrome Respirat\u00f3ria Aguda Grave em gestantes e pu\u00e9rperas portadoras da COVID-19","volume":"30","author":"APN Godoi","year":"2021","journal-title":"Rev Bras Saude Mater Infant"},{"issue":"5","key":"pone.0269091.ref033","doi-asserted-by":"crossref","first-page":"101620","DOI":"10.1016\/j.bjid.2021.101620","article-title":"Characteristics and outcomes of pregnant women with SARS-CoV-2 infection and other severe acute respiratory infections (SARI) in Brazil from January to November 2020","volume":"25","author":"LF Leal","year":"2021","journal-title":"Braz J Infect Dis"},{"issue":"10269","key":"pone.0269091.ref034","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0140-6736(20)32661-1","article-title":"Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK","volume":"397","author":"M Voysey","year":"2020","journal-title":"The Lancet"},{"issue":"8","key":"pone.0269091.ref035","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1007\/s00405-020-05965-1","article-title":"Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study","volume":"277","author":"JR Lechien","year":"2020","journal-title":"Eur Arch of Otorhinolaryngol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0269091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T17:53:19Z","timestamp":1655315599000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0269091"}},"subtitle":[],"editor":[{"given":"Antonio Simone","family":"Lagan\u00e0","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,6,15]]},"references-count":35,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,6,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0269091","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,15]]}}}