{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:45:35Z","timestamp":1780339535750,"version":"3.54.1"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T00:00:00Z","timestamp":1656547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Although the Interferon Gamma Release Assays (IGRA) is often used to identify latent tuberculosis, it also plays a crucial role in diagnosing active extrapulmonary tuberculosis. Some studies have assessed the use of IGRA as a biomarker for osteoarticular tuberculosis (OATB), which is elevated following TB infection. Still, conclusive results about its effectiveness have not been reported.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Method<\/jats:title>\n<jats:p>We searched PubMed, Embase, and Cochran databases. We obtained literature related to the diagnosis of OATB by IGRA, and the retrieval period was from the establishment of the database to June 2021. The bivariate random effect model was used to summarize the sensitivity, specificity, and accuracy of other indicators in diagnosing OATB by IGRA, and the forest plot and receiver operating characteristic (ROC) curve were used for testing.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>We included seven studies involving 643 subjects in diagnosing OATB by IGRA. The comprehensive sensitivity and specificity were 0.84 (95% CI, 0.70\u20130.92) and 0.78 (95% CI, 0.66\u20130.87), respectively. The area under the curve (AUC) was 0.87.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>In blood samples, the diagnostic accuracy of IGRAS is poor in patients with suspected OAT. We conclude that IGRA may not be appropriate for patients with OATB.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0269234","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T17:46:54Z","timestamp":1656611214000},"page":"e0269234","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Interferon gamma release assays for diagnosis of osteoarticular tuberculosis: A systematic review and meta-analysis"],"prefix":"10.1371","volume":"17","author":[{"given":"Chunnian","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangfeng","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,6,30]]},"reference":[{"issue":"2","key":"pone.0269234.ref001","doi-asserted-by":"crossref","first-page":"e22260","DOI":"10.1002\/jcla.22260","article-title":"Application of molecular, microbiological, and immunological tests for the diagnosis of bone and joint tuberculosis","volume":"32","author":"Y Tang","year":"2018","journal-title":"J Clin Lab Anal"},{"issue":"1","key":"pone.0269234.ref002","doi-asserted-by":"crossref","first-page":"5882","DOI":"10.1038\/s41598-018-24285-3","article-title":"Prospective Comparison of QFT-GIT and T-SPOT.TB Assays for Diagnosis of Active Tuberculosis","volume":"8","author":"F Du","year":"2018","journal-title":"Sci Rep"},{"issue":"7","key":"pone.0269234.ref003","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1046\/j.1440-1746.1999.01940.x","article-title":"Colonic tuberculosis: clinical features, endoscopic appearance and management","volume":"14","author":"SP Misra","year":"1999","journal-title":"J Gastroenterol Hepatol"},{"issue":"2","key":"pone.0269234.ref004","first-page":"61","article-title":"Extrapulmonary tuberculosis: are statistical reports accurate?","volume":"2","author":"E. 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