{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:32:15Z","timestamp":1790890335120,"version":"4.1.0"},"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T00:00:00Z","timestamp":1672358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Government of Ethiopia HIV prevention office","award":["ETH-H-HAPCO-1553."],"award-info":[{"award-number":["ETH-H-HAPCO-1553."]}]},{"DOI":"10.13039\/100009054","name":"U.S. President\u2019s Emergency Plan for AIDS Relief","doi-asserted-by":"crossref","award":["U2GGH001226"],"award-info":[{"award-number":["U2GGH001226"]}],"id":[{"id":"10.13039\/100009054","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hepatitis B and C virus infections are endemic diseases in sub-Saharan Africa, the region with the highest prevalence of these infections in the world. Female sex workers are exposed to sexually transmitted infections, including hepatitis B and C, because of their high-risk sexual behavior and limited access to health services. There are no large-scale data on the prevalence of hepatitis B and C virus infections among female sex workers in Ethiopia, a critical gap in information this study aimed to fill.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      <jats:bold>This was a<\/jats:bold>\n                      cross-sectional, biobehavioral survey conducted from December 2019\u2014April 2020 among 6085 female sex workers aged \u226515 years and residing in sixteen (16) regional capital cities and selected major towns of Ethiopia. Blood samples were collected from the participants for hepatitis B and C virus serological testing. The data were collected using an open data kits (ODK) software and imported into STATA version16 for analysis. Descriptive statistics (frequencies and proportions) were used to summarize data on the study variables. Bivariable and multivariable logistic regression analyses were conducted to determine the strength of association between independent variables (risk factors) and the outcome (hepatitis B and C virus infection). Adjusted Odd ratio (AOR) was used to determine independent associations, 95% confidence interval to assess precision of the estimates, and a\n                      <jats:italic>P<\/jats:italic>\n                      value \u2264 0.05 to determine statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The prevalence of hepatitis B and C infections among the 6085 female sex workers was 2.6% [(95% CI (2.2,2.8)] and 0.5% [(95% CI (0.4,0.7)], respectively. Female sex workers who had 61\u201390 and \u226591 paying clients in the past six months [(AOR = 1.66; 95% CI, (0.99, 2.79);\n                      <jats:italic>P<\/jats:italic>\n                      = 0.054] and [(AOR = 1.66 95% CI, (1.11, 2.49); P = 0.013], respectively, age at first sex selling of 20\u201324 and &gt;25 years [(AOR = 1.67; 95% CI, (1.14, 2.44);\n                      <jats:italic>P<\/jats:italic>\n                      = 0.009)] and [(AOR = 1.56; 95% CI (1.004, 2.43);\n                      <jats:italic>P<\/jats:italic>\n                      = 0.048)], respectively, known HIV positive status [(AOR = 1.64; 95% CI (1.03, 2.62);\n                      <jats:italic>P<\/jats:italic>\n                      = 0.036] were significantly associated with the prevalence of hepatitis B virus infection. Similarly, hepatitis C was significantly associated with, age at first sex \u226415 years and age 16\u201320 years [(AOR = 0.21; 95%CI (0.07,0.61);\n                      <jats:italic>P<\/jats:italic>\n                      = 0.005)] and [(AOR = 0.18; 95% CI (0.061, 0.53);\n                      <jats:italic>P<\/jats:italic>\n                      = 0.002)], respectively, known HIV positive status [(AOR = 2.85; 95%CI (1.10,7.37);\n                      <jats:italic>P<\/jats:italic>\n                      = 0.031)] and testing positive for syphilis [(AOR = 4.38; 95% CI (1.73,11.11);\n                      <jats:italic>P<\/jats:italic>\n                      = 0.002)], respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This analysis reveals an intermediate prevalence of hepatitis B and a low prevalence of hepatitis C infection among female sex workers in Ethiopia. It also suggests that population groups like female sex workers are highly vulnerable to hepatitis B, hepatitis C, and other sexually transmitted infections. There is a need for strengthening treatment and prevention interventions, including immunization services for hepatitis B vaccination, increasing HCV testing, and provision of treatment services.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0269510","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T13:46:55Z","timestamp":1672408015000},"page":"e0269510","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Prevalence and factors associated with hepatitis B and C virus infections among female Sex workers in Ethiopia: Results of the national biobehavioral Survey, 2020"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2784-3564","authenticated-orcid":true,"given":"Birra Bejiga","family":"Bedassa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemechu Gudeta","family":"Ebo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jemal Ayalew","family":"Yimam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaleta Bulti","family":"Tura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1153-2355","authenticated-orcid":true,"given":"Feyiso Bati","family":"Wariso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sileshi","family":"Lulseged","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Getachew Tollera","family":"Eticha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsigereda Kifle","family":"Wolde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saro Abdella","family":"Abrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,12,30]]},"reference":[{"issue":"1","key":"pone.0269510.ref001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12889-020-08893-1","article-title":"Prevalence and associated risk factors for Hepatitis B and C viruses among refugees in Gambella, Ethiopia","volume":"20","author":"A Ayele","year":"2020","journal-title":"BMC Public Health"},{"key":"pone.0269510.ref002","unstructured":"World Health Organization(WHO). Hepatitis B. Department of Communicable Diseases Surveillance and Response WHO\/CDS\/CSR\/LYO 2002. 2002. 2002."},{"issue":"9","key":"pone.0269510.ref003","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1111\/jvh.12123","article-title":"Viral hepatitis and the Global Burden of Disease: a need to regroup","volume":"20","author":"G Cooke","year":"2013","journal-title":"Journal of viral hepatitis"},{"issue":"10049","key":"pone.0269510.ref004","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/S0140-6736(16)30579-7","article-title":"The global burden of viral hepatitis from 1990 to 2013: findings from the Global Burden of Disease Study 2013","volume":"388","author":"JD Stanaway","year":"2016","journal-title":"The Lancet"},{"issue":"1","key":"pone.0269510.ref005","first-page":"1","volume":"17","author":"BE Feleke","year":"2020","journal-title":"Impacts of hepatitis B and hepatitis C co-infection with tuberculosis, a prospective cohort study"},{"key":"pone.0269510.ref006","author":"World Health Organization (WHO)","year":"2012","journal-title":"Prevention and treatment of HIV and other sexually transmitted infections for sex workers in low-and middle-income countries: recommendations for a public health approach"},{"issue":"4","key":"pone.0269510.ref007","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.respe.2011.02.102","article-title":"HIV infection and STI in the trans population: a critical review","volume":"59","author":"A Giami","year":"2011","journal-title":"Revue d\u2019epidemiologie et de sante publique"},{"key":"pone.0269510.ref008","volume-title":"Progress report on HIV, viral hepatitis and sexually transmitted infections 2019: accountability for the global health sector strategies, 2016\u20132021","author":"World Health Organization (WHO)","year":"2019"},{"issue":"4","key":"pone.0269510.ref009","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1007\/s10461-011-9985-z","article-title":"Socio-demographic characteristics and behavioral risk factors of female sex workers in sub-saharan Africa: a systematic review","volume":"16","author":"F Scorgie","year":"2012","journal-title":"AIDS and Behavior"},{"key":"pone.0269510.ref010","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1590\/0037-8682-0231-2017","article-title":"High-risk behaviors for hepatitis B and C infections among female sex workers","volume":"51","author":"MAM Puga","year":"2018","journal-title":"Revista da Sociedade Brasileira de Medicina Tropical"},{"issue":"12","key":"pone.0269510.ref011","first-page":"e0259891","volume":"16","author":"AM Bitty-Anderson","year":"2021","journal-title":"Prevalence of hepatitis B and C among female sex workers in Togo, West Africa"},{"key":"pone.0269510.ref012","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6650333","article-title":"Seroprevalence and associated factors of human immunodeficiency virus, treponema pallidum, hepatitis B virus, and hepatitis C virus among female sex workers in Dessie City, Northeast Ethiopia","volume":"2021","author":"Y Metaferia","year":"2021","journal-title":"BioMed Research International"},{"issue":"1","key":"pone.0269510.ref013","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ijid.2008.06.019","article-title":"Hepatitis B and hepatitis C in Pakistan: prevalence and risk factors","volume":"13","author":"SA Ali","year":"2009","journal-title":"International journal of infectious diseases"},{"issue":"7","key":"pone.0269510.ref014","doi-asserted-by":"crossref","first-page":"e036711","DOI":"10.1136\/bmjopen-2019-036711","article-title":"Role of unsafe medical practices and sexual behaviours in the hepatitis B and C syndemic and HIV co-infection in Rwanda: a cross-sectional study","volume":"10","author":"JD Makuza","year":"2020","journal-title":"BMJ open"},{"key":"pone.0269510.ref015","unstructured":"ICF CICsaCEa. Ethiopia demographic and health survey, Addis Ababa, Ethiopia and Calverton, Maryland, USA. 2016."},{"key":"pone.0269510.ref016","unstructured":"Federal Ministry of Health (FMO) AA, Ethiopia. National strategy for prevention and control of viral hepatitis. 2016."},{"issue":"1","key":"pone.0269510.ref017","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12879-016-2090-1","article-title":"Hepatitis viruses in Ethiopia: a systematic review and meta-analysis","volume":"16","author":"Y Belyhun","year":"2016","journal-title":"BMC infectious diseases"},{"key":"pone.0269510.ref018","first-page":"5915","author":"M Wondmagegn","year":"2022","journal-title":"Seroprevalence of Hepatitis B Virus, Hepatitis C Virus, Syphilis and Associated Factors Among Female Sex Workers in Gondar Town, Northwest Ethiopia"},{"key":"pone.0269510.ref019","author":"D Daka","year":"2020","journal-title":"Sero-prevalence of Hepatitis B Surface Antigen and Associated Factors Among Female Sex Workers in Hawassa, Ethiopia, 2019"},{"issue":"3","key":"pone.0269510.ref020","doi-asserted-by":"crossref","DOI":"10.4314\/ejhd.v20i3.46836","article-title":"Seroprevalence of HIV, hepatitis B infections and syphilis among street dwellers in Gondar city, Northwest Ethiopia","volume":"20","author":"F Moges","year":"2006","journal-title":"Ethiopian Journal of Health Development"},{"issue":"1","key":"pone.0269510.ref021","first-page":"135","article-title":"Prevalence and factors associated with HIV and hepatitis B virus infections among female commercial sex workers in Mekelle, Ethiopia: cross sectional study","volume":"6","author":"G Bugssa","year":"2015","journal-title":"Research"},{"key":"pone.0269510.ref022","unstructured":"Towns L, Ababa A. HIV\/AIDS in Ethiopia. 2014."},{"key":"pone.0269510.ref023","unstructured":"(EPHI) EPHI. Ethiopia population-based HIV impact Assessment (EPHIA) 2017\u20132018:Final Report Addis Ababa: EPHIA: August 2020.EPHIA project: http:\/\/www.ephia.gov.et, The PHIA Project.. 2017\u20132018."},{"issue":"1","key":"pone.0269510.ref024","first-page":"285","volume":"40","author":"KJ Gile","year":"2010","journal-title":"7. Respondent-driven sampling: An assessment of current methodology"},{"issue":"6","key":"pone.0269510.ref025","first-page":"448","volume":"74","author":"L Ju\u00e1rez-Figueroa","year":"1998","journal-title":"Low prevalence of hepatitis B markers among Mexican female sex workers"},{"issue":"5","key":"pone.0269510.ref026","first-page":"368","volume":"11","author":"N Kassaian","year":"2011","journal-title":"Hepatitis B and C among women with illegal social behavior in Isfahan, Iran: Seroprevalence and associated factors"},{"issue":"6","key":"pone.0269510.ref027","first-page":"662","article-title":"Prevalence of sexually transmitted infections in female sex workers in Athens, Greece\u2212 2005","volume":"16","author":"H Papadogeorgaki","year":"2006","journal-title":"European Journal of Dermatology"},{"issue":"4","key":"pone.0269510.ref028","first-page":"517","volume":"10","author":"ADC Passos","year":"2007","journal-title":"Hepatitis B among female sex workers in Ribeir\u00e3o Preto-S\u00e3o Paulo, Brazil"},{"issue":"1","key":"pone.0269510.ref029","first-page":"1","volume":"17","author":"M Mutagoma","year":"2017","journal-title":"Syphilis and HIV prevalence and associated factors to their co-infection, hepatitis B and hepatitis C viruses prevalence among female sex workers in Rwanda"},{"key":"pone.0269510.ref030","first-page":"219","volume":"50","author":"J Forbi","year":"2008","journal-title":"High prevalence of hepatitis B virus among female sex workers in Nigeria"},{"issue":"6","key":"pone.0269510.ref031","first-page":"e0129247","volume":"10","author":"G Kerubo","year":"2015","journal-title":"Hepatitis B, hepatitis C and HIV-1 coinfection in two informal urban settlements in Nairobi, Kenya"},{"issue":"9","key":"pone.0269510.ref032","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1128\/JCM.40.9.3523-3525.2002","article-title":"Prevalence of blood-borne infectious diseases in blood donors in Ghana","volume":"40","author":"W Ampofo","year":"2002","journal-title":"Journal of clinical microbiology"},{"key":"pone.0269510.ref033","first-page":"165","volume":"45","author":"JL V\u00e1zquez-Mart\u00ednez","year":"2003","journal-title":"G\u00f3mez-Dant\u00e9s HJspdm. Seroprevalence of hepatitis B in pregnant women in Mexico"},{"key":"pone.0269510.ref034","volume-title":"Joint United Nations Programme on HIV\/AIDS, Global Network of Sex Work Projects. Prevention and treatment of HIV and other sexually transmitted infections for sex workers in lowand middle-income countries: recommendations for a public health approach","author":"United Nation (UN), World Health Organization (WHO)","year":"2012"},{"issue":"2","key":"pone.0269510.ref035","first-page":"234","article-title":"A Study on the HBV and the HCV Infections in Female Sex Workers and their Co-Infection with HIV","volume":"7","author":"D. Anuradha","year":"2013","journal-title":"Journal of clinical and diagnostic research: JCDR"},{"issue":"5","key":"pone.0269510.ref036","first-page":"636","volume":"17","author":"RdLB Magalh\u00e3es","year":"2016","journal-title":"Risk practices and immunization against hepatitis B among female sex workers"},{"issue":"4","key":"pone.0269510.ref037","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1080\/14681994.2020.1778165","article-title":"HBV, HCV and HIV among female sex workers; is it a health problem?","volume":"35","author":"AG Farghaly","year":"2020","journal-title":"Sexual and Relationship Therapy"},{"issue":"4","key":"pone.0269510.ref038","first-page":"215","article-title":"Prevalence of human immunodeficiency virus, hepatitis B and hepatitis C virus antibodies and hepatitis B antigen among commercial sex workers in Japan","volume":"9","author":"K Ishi","year":"2001","journal-title":"Gynecology"},{"issue":"0 2","key":"pone.0269510.ref039","first-page":"S69","volume":"24","author":"CS Todd","year":"2010","journal-title":"HIV, hepatitis B, and hepatitis C prevalence and associated risk behaviors among female sex workers in three Afghan cities"},{"issue":"9","key":"pone.0269510.ref040","doi-asserted-by":"crossref","first-page":"e24721","DOI":"10.1371\/journal.pone.0024721","article-title":"HBV infection in relation to consistent condom use: a population-based study in Peru","volume":"6","author":"A Bernabe-Ortiz","year":"2011","journal-title":"PLoS One"},{"issue":"6","key":"pone.0269510.ref041","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1177\/2325957417732836","article-title":"Prevalence of sexually transmitted infections and their risk factors among female sex workers in Isfahan, Iran: a cross-sectional study","volume":"16","author":"M Nasirian","year":"2017","journal-title":"Journal of the International Association of Providers of AIDS Care (JIAPAC)"},{"issue":"1","key":"pone.0269510.ref042","first-page":"1","volume":"10","author":"B Tessema","year":"2010","journal-title":"Seroprevalence of HIV, HBV, HCV and syphilis infections among blood donors at Gondar University Teaching Hospital, Northwest Ethiopia: declining trends over a period of five years"},{"issue":"1","key":"pone.0269510.ref043","first-page":"49","volume":"263","author":"CE Stevens","year":"1990","journal-title":"Epidemiology of hepatitis C virus: a preliminary study in volunteer blood donors"},{"issue":"8","key":"pone.0269510.ref044","doi-asserted-by":"crossref","first-page":"658","DOI":"10.7326\/0003-4819-125-8-199610150-00006","article-title":"Hepatitis C update","volume":"125","author":"A CM Scharara","year":"1996","journal-title":"Ann Intern Med"},{"key":"pone.0269510.ref045","unstructured":"World Health Organization (WHO). Global progress report on HIV, viral hepatitis and sexually transmitted infections, 2021: accountability for the global health sector strategies 2016\u20132021: actions for impact: web annex 2: data methods. 2021."},{"issue":"6","key":"pone.0269510.ref046","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1007\/s10508-019-01574-0","article-title":"HIV and other sexually transmitted infections among female sex workers in Iran: a systematic review and meta-analysis","volume":"49","author":"M Karamouzian","year":"2020","journal-title":"Archives of sexual behavior"},{"issue":"5","key":"pone.0269510.ref047","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/S0035-9203(98)90887-2","article-title":"Prevalence and genotype of hepatitis C virus infection in pregnant women and blood donors in Ghana","volume":"92","author":"M Wansbrough-Jonesl","year":"1998","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"issue":"5","key":"pone.0269510.ref048","first-page":"449","volume":"15","author":"B Koate","year":"2005","journal-title":"Seroprevalence of hepatitis C virus among blood donors in Rivers State, Nigeria"},{"issue":"4","key":"pone.0269510.ref049","first-page":"165","article-title":"Prevalence of antibodies to syphilis among blood donors in Accra, Ghana","volume":"56","author":"AA Adjei","year":"2003","journal-title":"Japanese journal of infectious diseases"},{"issue":"1","key":"pone.0269510.ref050","first-page":"1","volume":"6","author":"MI Matee","year":"2006","journal-title":"Seroprevalence of human immunodeficiency virus, hepatitis B and C viruses and syphilis infections among blood donors at the Muhimbili National Hospital in Dar Es Salaam, Tanzania"},{"issue":"4","key":"pone.0269510.ref051","first-page":"872","volume":"30","author":"C Laurent","year":"2001","journal-title":"Seroepidemiological survey of hepatitis C virus among commercial sex workers and pregnant women in Kinshasa, Democratic Republic of Congo"},{"issue":"1","key":"pone.0269510.ref052","volume":"13","author":"HG Ouedraogo","year":"2019","journal-title":"Hepatitis B, C and delta viruses\u2019 infections and correlate factors among female sex workers in Burkina Faso, West-Africa"},{"issue":"12","key":"pone.0269510.ref053","first-page":"e1024","article-title":"Hepatitis B\/C and HIV in sub-Saharan Africa: an association between highly prevalent infectious diseases","volume":"14","author":"RE Barth","year":"2010","journal-title":"A systematic review and meta-analysis"},{"issue":"1","key":"pone.0269510.ref054","first-page":"87","volume":"15","author":"M Aklilu","year":"2001","journal-title":"Factors associated with HIV-1 infection among sex workers of Addis Ababa, Ethiopia"},{"issue":"1","key":"pone.0269510.ref055","first-page":"12","volume":"68","author":"W Ayele","year":"2002","journal-title":"Higher prevalence of anti-HCV antibodies among HIV-positive compared to HIV-negative inhabitants of Addis Ababa, Ethiopia"},{"issue":"2","key":"pone.0269510.ref056","first-page":"e0115311","volume":"10","author":"Y Chen","year":"2015","journal-title":"Bridging the epidemic: a comprehensive analysis of prevalence and correlates of HIV, hepatitis C, and syphilis, and infection among female sex workers in Guangxi Province, China"},{"issue":"9","key":"pone.0269510.ref057","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1007\/s00705-020-04716-1","article-title":"Global prevalence of HCV and\/or HBV coinfections among people who inject drugs and female sex workers who live with HIV\/AIDS: a systematic review and meta-analysis","volume":"165","author":"R Rashti","year":"2020","journal-title":"Archives of virology"},{"issue":"6","key":"pone.0269510.ref058","doi-asserted-by":"crossref","first-page":"432","DOI":"10.3390\/pathogens9060432","article-title":"Systematic review and meta-analysis of global prevalence of HBsAg and HIV and HCV antibodies among people who inject drugs and female sex workers","volume":"9","author":"R Rashti","year":"2020","journal-title":"Pathogens"},{"issue":"3","key":"pone.0269510.ref059","doi-asserted-by":"crossref","first-page":"230","DOI":"10.2471\/BLT.18.219469","article-title":"Countdown to 2030: eliminating hepatitis B disease, China","volume":"97","author":"J Liu","year":"2019","journal-title":"Bulletin of the World Health Organization"},{"issue":"10003","key":"pone.0269510.ref060","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1016\/S0140-6736(15)61412-X","article-title":"Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965 and 2013","volume":"386","author":"A Schweitzer","year":"2015","journal-title":"The Lancet"},{"key":"pone.0269510.ref061","unstructured":"World Health Organization (WHO). 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