{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T16:01:57Z","timestamp":1784044917013,"version":"3.55.0"},"reference-count":59,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T00:00:00Z","timestamp":1655164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Whether there are sex differences in hemodynamic profiles among people with elevated blood pressure is not well understood and could guide personalization of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We described the clinical and hemodynamic characteristics of adults with elevated blood pressure in China using impedance cardiography. We included 45,082 individuals with elevated blood pressure (defined as systolic blood pressure of \u2265130 mmHg or a diastolic blood pressure of \u226580 mmHg), of which 35.2% were women. Overall, women had a higher mean systolic blood pressure than men (139.0 [\u00b115.7] mmHg vs 136.8 [\u00b113.8] mmHg, P&lt;0.001), but a lower mean diastolic blood pressure (82.6 [\u00b19.0] mmHg vs 85.6 [\u00b18.9] mmHg, P&lt;0.001). After adjusting for age, region, and body mass index, women &lt;50 years old had lower systemic vascular resistance index (beta-coefficient [\u03b2] -31.7; 95% CI: -51.2, -12.2) and higher cardiac index (\u03b2 0.07; 95% CI: 0.04, 0.09) than men of their same age group, whereas among those \u226550 years old women had higher systemic vascular resistance index (\u03b2 120.4; 95% CI: 102.4, 138.5) but lower cardiac index (\u03b2 -0.15; 95% CI: -0.16, -0.13). Results were consistent with a propensity score matching sensitivity analysis, although the magnitude of the SVRI difference was lower and non-significant. However, there was substantial overlap between women and men in the distribution plots of these variables, with overlapping areas ranging from 78% to 88%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings indicate that there are sex differences in hypertension phenotype, but that sex alone is insufficient to infer an individual\u2019s profile.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0269777","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T13:51:07Z","timestamp":1655214667000},"page":"e0269777","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Hemodynamic differences between women and men with elevated blood pressure in China: A non-invasive assessment of 45,082 adults using impedance cardiography"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4557-9437","authenticated-orcid":true,"given":"C\u00e9sar","family":"Caraballo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5617-489X","authenticated-orcid":true,"given":"Shiwani","family":"Mahajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlei","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica S.","family":"Spatz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel P.","family":"Dreyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MaoZhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NingLing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihong","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng J.","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harlan M.","family":"Krumholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,6,14]]},"reference":[{"issue":"Pt 21","key":"pone.0269777.ref001","doi-asserted-by":"crossref","first-page":"5285","DOI":"10.1113\/jphysiol.2011.212753","article-title":"Sex and ageing differences in resting arterial pressure regulation: the role of the beta-adrenergic receptors","volume":"589","author":"EC Hart","year":"2011","journal-title":"J Physiol"},{"issue":"3","key":"pone.0269777.ref002","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1161\/HYPERTENSIONAHA.108.126391","article-title":"Sex differences in sympathetic neural-hemodynamic balance: implications for human blood pressure regulation","volume":"53","author":"EC 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