{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:44:19Z","timestamp":1790304259027,"version":"4.1.0"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2018\/07178-3"],"award-info":[{"award-number":["2018\/07178-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88887.461810\/2019-00"],"award-info":[{"award-number":["88887.461810\/2019-00"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Non-cystic fibrosis bronchiectasis (NCFB) is a heterogeneous disease, which assessment and severity can\u2019t be defined by one particular instrument but using a multidimensional score. Thus, in additional to traditional methods, alternative tools have been developed to assist these patients\u2019 evaluation.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Objective<\/jats:title>\n<jats:p>To correlate functional and morphological indexes with severity and dyspnea in NCFB patients, focusing on the correlation between the impulse oscillometry system (IOS) and the quantitative analysis of computed tomography (CT).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Clinically stable NCFB patients, between 18 and 80 years old were submitted to clinical, functional and morphological evaluations assessed by Bronchiectasis Severity Index (BSI) and Medical Research Council (MRC) scale; spirometry and IOS; and subjective and quantitative Chest CT scans analysis, respectively.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Results<\/jats:title>\n<jats:p>This study included 38 patients. The best correlations obtained between functional and morphological airway indexes were: resistance at 5 Hz\u2014R5 and the normalized thickness of bronchial walls\u2014Pi10 (r = 0.57), and the mean forced expiratory flow (FEF<jats:sub>25-75%<\/jats:sub>) and CT score (r = -0.39). BSI as well as MRC showed higher correlations with the quantitative automated analysis of CT (BSI and Pi10: r = 0.41; MRC and Pi10: r = 0.35) than with subjective CT score (BSI and CT score: r = 0.41; MRC and CT score: r = 0.15); and moderate and weak correlations were obtained on both functional airway indexes (BSI and peripheral airways resistance - R5-R20: r = 0.53; BSI and forced expiratory volume at the first second\u2014FEV<jats:sub>1<\/jats:sub>: R = -0,64; MRC and R5-R20: r = 0.42; and MRC and VEF<jats:sub>1<\/jats:sub>: r = -0.45).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>In NCFB patients, compartmentalized methods for assessing the respiratory system (IOS and the automated quantitative CT analysis) have a good correlation with severity and dyspnea.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0269897","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T17:36:22Z","timestamp":1657128982000},"page":"e0269897","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Correlation among clinical, functional and morphological indexes of the respiratory system in non-cystic fibrosis bronchiectasis patients"],"prefix":"10.1371","volume":"17","author":[{"given":"J\u00e9ssica","family":"Perossi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7160-4691","authenticated-orcid":true,"given":"Marcel","family":"Koenigkam-Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Perossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele Oliveira","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Let\u00edcia Helena de Souza","family":"Simoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo Celso Dutra","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9845-3611","authenticated-orcid":true,"given":"Ada Clarice","family":"Gastaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,7,6]]},"reference":[{"key":"pone.0269897.ref001","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1164\/ajrccm\/146.6.1430","article-title":"Mucus Hypersecretion in Bronchiectasis","volume":"145","author":"JV Fahy","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"pone.0269897.ref002","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1378\/chest.08-0776","article-title":"Bronchiectasis","volume":"134","author":"AE O\u2019Donnell","year":"2008","journal-title":"Chest"},{"key":"pone.0269897.ref003","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1136\/pgmj.2009.091041","article-title":"Non-cystic fibrosis bronchiectasis: diagnosis and management in 21st century","volume":"86","author":"P Goeminne","year":"2010","journal-title":"Postgrad Med J"},{"key":"pone.0269897.ref004","doi-asserted-by":"crossref","first-page":"249","DOI":"10.4046\/trd.2012.73.5.249","article-title":"Bronchiectasis","volume":"73","author":"C Kim","year":"2012","journal-title":"Tuberc Respir Dis"},{"key":"pone.0269897.ref005","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1183\/09031936.04.00142903","article-title":"HRCT lung abnormalities are not a surrogate for exercise limitation in bronchiectasis","volume":"24","author":"EA Edwards","year":"2004","journal-title":"Eur Respir J"},{"issue":"5","key":"pone.0269897.ref006","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1164\/rccm.201309-1575OC","article-title":"The Bronchiectasis Severity Index","volume":"189","author":"JD Chalmers","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"pone.0269897.ref007","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1183\/09031936.00026313","article-title":"Multidimensional approach to non-cystic fibrosis bronchiectasis: the FACED score","volume":"43","author":"MA Martinez-Garcia","year":"2014","journal-title":"Eur Respir J"},{"key":"pone.0269897.ref008","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2147\/COPD.S121943","article-title":"Predicting high risk of exacerbations in bronchiectasis: the E-FACED score","volume":"12","author":"MA Martinez-Garcia","year":"2017","journal-title":"International Journal of COPD"},{"issue":"5","key":"pone.0269897.ref009","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1590\/S1806-37132015000004517","article-title":"Determining respiratory system resistance and reactance by impulse oscillometry in obese individuals","volume":"41","author":"CG Albuquerque","year":"2015","journal-title":"J Bras Pneumol"},{"issue":"1","key":"pone.0269897.ref010","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1183\/20734735.020514","article-title":"Measuring lung function using sound waves: role of the forced oscillation technique and impulse oscillometry system","volume":"11","author":"B Brashier","year":"2015","journal-title":"Breathe (Sheff)"},{"key":"pone.0269897.ref011","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1136\/thx.2009.120790","article-title":"Comparison of inspiratory and expiratory resistance and reactance in patients with asthma and chronic obstructive pulmonar disease","volume":"65","author":"P Paredi","year":"2010","journal-title":"Thorax"},{"key":"pone.0269897.ref012","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.soard.2011.08.004","article-title":"Distal airway dysfunction in obese subjects corrects after bariatric surgery","volume":"8","author":"BW Oppenheimer","year":"2012","journal-title":"Surgery for Obesity and Related Diseases"},{"issue":"42","key":"pone.0269897.ref013","doi-asserted-by":"crossref","first-page":"e1845","DOI":"10.1097\/MD.0000000000001845","article-title":"Oscillating Positive Expiratory Pressure on Respiratory Resistance in Chronic Obstructive Pulmonary Disease with a Small Amount of Secretion","volume":"94","author":"AC Gastaldi","year":"2015","journal-title":"Medicine"},{"key":"pone.0269897.ref014","doi-asserted-by":"crossref","first-page":"261","DOI":"10.2214\/ajr.165.2.7618537","article-title":"CT findings in Bronchiectasis: Limited value in distinguishing between idiopathic and specific types","volume":"165","author":"DB Reiff","year":"1995","journal-title":"AJR"},{"issue":"1","key":"pone.0269897.ref015","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1109\/TMI.2007.902798","article-title":"About objective 3-D analysis of airway geometry in computerized tomography","volume":"27","author":"O Weinheimer","year":"2008","journal-title":"IEEE Transactions on Medical Imaging"},{"issue":"12","key":"pone.0269897.ref016","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1590\/S1806-37132008001200005","article-title":"Validation of the Modified Pulmonary Functional Status and Dyspnea Questionnaire and the Medical Research Council scale for use in Brazilian patients with chronic obstructive pulmonary disease","volume":"34","author":"D Kovelis","year":"2008","journal-title":"J Bras Pneumol"},{"key":"pone.0269897.ref017","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1183\/09031936.05.00034805","article-title":"Standardisation of spirometry","volume":"26","author":"MR Miller","year":"2005","journal-title":"Eur Respir J"},{"key":"pone.0269897.ref018","first-page":"659","article-title":"Reference spirometric values using techniques and equipment that meet ATS recommendations","volume":"123","author":"RO Crapo","year":"1981","journal-title":"Am Rev Respir Dis"},{"key":"pone.0269897.ref019","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1183\/09031936.03.00089403","article-title":"The forced oscillation technique in clinical practice: methodology, recommendations and future developments","volume":"22","author":"E Oostveen","year":"2003","journal-title":"Eur Respir J"},{"issue":"15","key":"pone.0269897.ref020","doi-asserted-by":"crossref","first-page":"565","DOI":"10.4187\/respcare.05471","article-title":"The influence of different mouthpieces on impulse oscillometry results","volume":"63","author":"GH Dionisio","year":"2018","journal-title":"Respir Care"},{"key":"pone.0269897.ref021","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1097\/RTI.0b013e3182277113","article-title":"Computed tomographic imaging of the airways in COPD and asthma","volume":"26","author":"HU Kauczor","year":"2011","journal-title":"J Thorac Imaging"},{"issue":"6","key":"pone.0269897.ref022","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1590\/0100-3984.2015.0145","article-title":"Quantitative computed tomography analysis os the airways in patients with cystic fibrosis using automated software: correlation with spirometry in the evaluation of severity","volume":"49","author":"M Koenigkam-Santos","year":"2016","journal-title":"Radiol Bras"},{"issue":"18","key":"pone.0269897.ref023","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1056\/NEJMra012519","article-title":"Bronchiectasis","volume":"346","author":"AF Barker","year":"2002","journal-title":"N Engl J Med"},{"key":"pone.0269897.ref024","doi-asserted-by":"crossref","first-page":"i1","DOI":"10.1136\/thx.2010.136119","article-title":"British Thoracic Society guideline for non-CF bronchiectasis","volume":"65","author":"MC Pasteur","year":"2010","journal-title":"Thorax"},{"key":"pone.0269897.ref025","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1148\/radiology.179.3.2027992","article-title":"Cystic Fibrosis: scoring system with thin-section CT","volume":"179","author":"M Bhalla","year":"1991","journal-title":"Radiology"},{"key":"pone.0269897.ref026","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1164\/ajrccm.162.4.9906120","article-title":"An investigation into causative factors in patients with bronchiectasis","volume":"162","author":"MC Pasteur","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"issue":"11","key":"pone.0269897.ref027","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.4187\/respcare.04710","article-title":"Impulse oscillometry and spirometry small-airway parameters in mild to moderate bronchiectasis","volume":"61","author":"WJ Guan","year":"2016","journal-title":"Respir Care"},{"issue":"2","key":"pone.0269897.ref028","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1097\/RTI.0b013e3182765785","article-title":"Automatic airway analysis on multidetector computed tomography in cystic fibrosis\u2013Correlation with pulmonary function testing","volume":"28","author":"MO Wielputz","year":"2013","journal-title":"J Thorac Imaging"},{"issue":"6","key":"pone.0269897.ref029","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1590\/0100-3984.2016.0163","article-title":"Use of computed tomography and automated software for quantitative analysis of the vasculature of patients with pulmonary hypertension","volume":"50","author":"DT Wada","year":"2017","journal-title":"Radiol Bras"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0269897","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T17:36:48Z","timestamp":1657129008000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0269897"}},"subtitle":[],"editor":[{"given":"Aleksandra","family":"Barac","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,7,6]]},"references-count":29,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,7,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0269897","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,6]]}}}