{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:17:41Z","timestamp":1747196261816,"version":"3.40.5"},"reference-count":25,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Purpose<\/jats:title>\n<jats:p>To evaluate a multivariable model predicting the individual probability of successful intravitreal ocriplasmin (IVO) treatment in eyes with vitreomacular traction (VMT).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Data from three prospective, multicenter IVO studies (OASIS, ORBIT, and INJECT) were pooled. Patients were included if they were treated for a symptomatic VMT without a full-thickness macular hole. A prediction model for VMT resolution using the factors \u2018age\u2019 and \u2018horizontal VMT diameter\u2019 was validated by receiver operating characteristic analysis and according to grouped prediction after calibration. Multivariable regression analysis was performed to check robustness and explore further improvements.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Data from 591 eyes was included. In the univariate analysis all key factors (age, gender, VMT diameter, lens status, ERM) significantly correlated to treatment success. The prediction model was robust and clinically applicable to estimate the success rate of IVO treatment (AUC of ROC: 0.70). A refinement of the model was achieved through a calibration process.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The developed multivariable model using \u2018horizontal VMT diameter\u2019 and \u2018age\u2019 is a valid tool for prediction of VMT resolution upon IVO treatment.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0270120","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T17:29:16Z","timestamp":1658770156000},"page":"e0270120","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Calculating the individual probability of successful ocriplasmin treatment in eyes with vitreomacular traction\u2013Validation and refinement of a multivariable prediction model"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6458-0302","authenticated-orcid":true,"given":"Christoph","family":"Paul","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Helge","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Raber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Bertelmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the EXPORT study group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2022,7,25]]},"reference":[{"issue":"12","key":"pone.0270120.ref001","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1016\/j.ophtha.2013.07.042","article-title":"The International Vitreomacular Traction Study Group classification of vitreomacular adhesion, traction, and macular hole","volume":"120","author":"JS Duker","year":"2013","journal-title":"Ophthalmology"},{"issue":"7","key":"pone.0270120.ref002","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1056\/NEJMoa1110823","article-title":"Enzymatic vitreolysis with ocriplasmin for vitreomacular traction and macular holes","volume":"367","author":"P Stalmans","year":"2012","journal-title":"The New England journal of medicine"},{"issue":"3","key":"pone.0270120.ref003","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1136\/bjophthalmol-2014-304961","article-title":"Rate and timing of spontaneous resolution in a vitreomacular traction group: should the role of watchful waiting be re-evaluated as an alternative to ocriplasmin therapy?","volume":"99","author":"S Dimopoulos","year":"2015","journal-title":"The British journal of ophthalmology"},{"issue":"4","key":"pone.0270120.ref004","first-page":"617","article-title":"A retrospective cohort study in patients with tractional diseases of the vitreomacular interface (ReCoVit). 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Stalmans","year":"2016","journal-title":"Ophthalmologie"},{"issue":"3","key":"pone.0270120.ref005","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/s41433-018-0230-0","article-title":"Patient-reported prevalence of metamorphopsia and predictors of vision-related quality of life in vitreomacular traction: a prospective, multi-centre study.","volume":"33","author":"PJ Patel","year":"2019","journal-title":"Eye (London, England)."},{"issue":"7","key":"pone.0270120.ref006","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/aos.13547","article-title":"Intravitreal gas for symptomatic vitreomacular adhesion: a synthesis of the literature.","volume":"96","author":"JE Neffendorf","year":"2018","journal-title":"Acta ophthalmologica."},{"key":"pone.0270120.ref007","article-title":"Pneumatic Vitreolysis with Perfluoropropane for Vitreomacular Traction with and without Macular Hole: DRCR Retina Network Protocols AG and AH","author":"CK Chan","year":"2021","journal-title":"Ophthalmology"},{"issue":"7","key":"pone.0270120.ref008","first-page":"1247","article-title":"Ocriplasmin use for vitreomacular traction and macular hole: A meta-analysis and comprehensive review on predictive factors for vitreous release and potential complications. 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