{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T21:16:48Z","timestamp":1787951808333,"version":"build-2784847793"},"reference-count":125,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T00:00:00Z","timestamp":1672358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Administrative Department of Science, Technology and Innovation of Colombia"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Zika Virus (ZIKV) is a flavivirus that is transmitted predominantly by the <jats:italic>Aedes<\/jats:italic> species of mosquito, but also through sexual contact, blood transfusions, and congenitally from mother to child. Although approximately 80% of ZIKV infections are asymptomatic and typical symptoms are mild, multiple studies have demonstrated a causal link between ZIKV and severe diseases such as Microcephaly and Guillain Barr\u00e9 Syndrome. Two goals of this study are to improve ZIKV models by considering the spread dynamics of ZIKV as both a vector-borne and sexually transmitted disease, and also to approximate the degree of under-reporting. In order to accomplish these objectives, we propose a compartmental model that allows for the analysis of spread dynamics as both a vector-borne and sexually transmitted disease, and fit it to the ZIKV incidence reported to the National System of Public Health Surveillance in 27 municipalities of Colombia between January 1 2015 and December 31 2017. We demonstrate that our model can represent the infection patterns over this time period with high confidence. In addition, we argue that the degree of under-reporting is also well estimated. Using the model we assess potential viability of public health scenarios for mitigating disease spread and find that targeting the sexual pathway alone has negligible impact on overall spread, but if the proportion of risky sexual behavior increases then it may become important. Targeting mosquitoes remains the best approach of those considered. These results may be useful for public health organizations and governments to construct and implement suitable health policies and reduce the impact of the Zika outbreaks.<\/jats:p>","DOI":"10.1371\/journal.pone.0270127","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T18:46:06Z","timestamp":1672425966000},"page":"e0270127","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Modeling the spread of the Zika virus by sexual and mosquito 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Mead","year":"2018","journal-title":"New England Journal of Medicine"},{"key":"pone.0270127.ref095","unstructured":"Profamilia, National Ministry of Health and Social Protection (Colombia). 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Large-scale vector-borne disease agent-based model, with application to Chikungunya in Colombia [phdthesis]. Universidad Nacional de Colombia; 2015."},{"key":"pone.0270127.ref103","unstructured":"National Administrative Department of Statistics (Colombia). COLOMBIA. Necesidades B\u00e1sicas Insatisfechas\u2014NBI, por total, cabecera y resto, seg\u00fan municipio y nacional; 2012. https:\/\/www.dane.gov.co\/censo\/files\/resultados\/NBI_total_dpto_30_Jun_2012.xls."},{"key":"pone.0270127.ref104","unstructured":"Tolosa N. Protocolo de Vigilancia en Salud P\u00fablica Enfermedad por Virus Zika; 2016. http:\/\/bvs.minsa.gob.pe\/local\/MINSA\/3449.pdf."},{"key":"pone.0270127.ref105","unstructured":"Bates D, Sarkar D. R: Optimization using PORT routines;. https:\/\/www.rdocumentation.org\/packages\/stats\/versions\/3.6.0\/topics\/nlminb."},{"key":"pone.0270127.ref106","unstructured":"Gay DM. Usage summary for selected optimization routines; 1990. https:\/\/ms.mcmaster.ca\/bolker\/misc\/port.pdf."},{"key":"pone.0270127.ref107","unstructured":"National Institute of Health (Colombia). Circular Conjunta Externa 043 de 2015; 2015. https:\/\/www.minsalud.gov.co\/sites\/rid\/Lists\/BibliotecaDigital\/RIDE\/DE\/DIJ\/circular-conjunta-externa-0043.pdf."},{"key":"pone.0270127.ref108","unstructured":"National Institute of Health (Colombia). 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