{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:24:26Z","timestamp":1792664666936,"version":"4.5.0"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:00:00Z","timestamp":1658793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Universidad Peruana de Ciencias Aplicadas","award":["A-190-2021"],"award-info":[{"award-number":["A-190-2021"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Background<\/jats:title><jats:p>Oropouche fever is an infectious disease caused by the Oropouche virus (OROV). The diagnosis and prediction of the clinical picture continue to be a great challenge for clinicians who manage patients with acute febrile syndrome. Several symptoms have been associated with OROV virus infection in patients with febrile syndrome; however, to date, there is no clinical prediction rule, which is a fundamental tool to help the approach of this infectious disease.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Objective<\/jats:title><jats:p>To assess the performance of a prediction model based solely on signs and symptoms to diagnose Oropouche virus infection in patients with acute febrile syndrome.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Materials and methods<\/jats:title><jats:p>Validation study, which included 923 patients with acute febrile syndrome registered in the Epidemiological Surveillance database of three arbovirus endemic areas in Peru.<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Results<\/jats:title><jats:p>A total of 97 patients (19%) were positive for OROV infection in the development group and 23.6% in the validation group. The area under the curve was 0.65 and the sensitivity, specificity, PPV, NPV, LR + and LR- were 78.2%, 35.1%, 27.6%, 83.6%, 1.20 and 0.62, respectively.<\/jats:p><\/jats:sec><jats:sec id=\"sec005\"><jats:title>Conclusions<\/jats:title><jats:p>The development of a clinical prediction model for the diagnosis of Oropouche based solely on signs and symptoms does not work well. This may be due to the fact that the symptoms are nonspecific and related to other arbovirus infections, which confuse and make it difficult to predict the diagnosis, especially in endemic areas of co-infection of these diseases. For this reason, epidemiological surveillance of OROV in various settings using laboratory tests such as PCR is important.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0270294","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T17:40:36Z","timestamp":1658857236000},"page":"e0270294","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":39,"title":["Oropouche virus infection in patients with acute febrile syndrome: Is a predictive model based solely on signs and symptoms useful?"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4385-7904","authenticated-orcid":true,"given":"Hilda V.","family":"Durango-Chavez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4664-2856","authenticated-orcid":true,"given":"Carlos J.","family":"Toro-Huamanchumo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilmer","family":"Silva-Caso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0051-4189","authenticated-orcid":true,"given":"Johanna","family":"Martins-Luna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel Angel","family":"Aguilar-Luis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juana","family":"del Valle-Mendoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5068-0986","authenticated-orcid":true,"given":"Zully M.","family":"Puyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,7,26]]},"reference":[{"issue":"5","key":"pone.0270294.ref001","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.4269\/ajtmh.16-0672","article-title":"Oropouche virus: Clinical, epidemiological, and molecular aspects of a neglected orthobunyavirus","volume":"96","author":"JF Travassos Da Rosa","year":"2017","journal-title":"Am J Trop Med Hyg"},{"key":"pone.0270294.ref002","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1099\/vir.0.061309-0","article-title":"Genomic and phylogenetic characterization of viruses included in the Manzanilla and Oropouche species complexes of the genus Orthobunyavirus, family Bunyaviridae","volume":"95","author":"JT Ladner","year":"2014","journal-title":"J Gen Virol"},{"key":"pone.0270294.ref003","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ijid.2019.04.011","article-title":"First outbreak of Oropouche Fever reported in a non-endemic western region of the Peruvian Amazon: Molecular diagnosis and clinical characteristics","volume":"83","author":"W Silva-Caso","year":"2019","journal-title":"Int J Infect Dis"},{"issue":"3","key":"pone.0270294.ref004","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.micinf.2017.11.013","article-title":"Oropouche fever, an emergent disease from the Americas","volume":"20","author":"D Romero-Alvarez","year":"2018","journal-title":"Microbes Infect [Internet]."},{"issue":"4","key":"pone.0270294.ref005","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3390\/v10040175","article-title":"Oropouche fever: A review.","volume":"10","author":"H Sakkas","year":"2018","journal-title":"Viruses [Internet]"},{"key":"pone.0270294.ref006","doi-asserted-by":"crossref","first-page":"574","DOI":"10.4269\/ajtmh.1961.10.574","article-title":"Oropouche virus: a new human disease agent from Trinidad, West Indies","volume":"10","author":"CR Anderson","year":"1961","journal-title":"Am J Trop Med Hyg"},{"key":"pone.0270294.ref007","first-page":"800","article-title":"Molecular epidemiology of oropouche virus, Brazil [Internet]. 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