{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:11:03Z","timestamp":1790673063636,"version":"4.1.0"},"reference-count":18,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T00:00:00Z","timestamp":1656460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Purpose<\/jats:title>\n<jats:p>To investigate the potential role of follow-up <jats:sup>18<\/jats:sup>F-fluorodeoxyglucose (FDG) positron emission tomography\/computed tomography (PET\/CT) in therapy control of inoperable patients with alveolar echinococcosis.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Materials and methods<\/jats:title>\n<jats:p>In this single-center retrospective cohort study, 48 PET\/CT of 16 patients with confirmed alveolar echinococcosis were analysed. FDG-uptake of the most active echinococcosis manifestation was measured (i.e., maximum standardized uptake value (SUVmax) and in relation to background activity in normal liver tissue (SUVratio)) and compared to immunodiagnostic testing. For clinical patient follow-up, patient demographics, laboratory data, including <jats:italic>E<\/jats:italic>. <jats:italic>granulosus<\/jats:italic> hydatid fluid (EgHF) antibody units (AU) as well as clinical and treatment information were assessed for all patients at the time of PET\/CT, and at the last recorded clinical visit.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Metabolic activity of PET\/CT measured in the echinococcosis manifestation was significantly correlated with EgHF AU (p &lt; 0.001). The differences in metabolic activity of echinococcosis manifestations between two consecutive PET\/CT examinations of the same patient and differences in EgHF AU in the respective time intervals displayed a significant positive correlation (p = 0.01). A trend for a more rapid decline in SUVratio liver over time was found in patients who stopped benzimidazole therapy versus patients who did not stop therapy (p = 0.059).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>In inoperable patients with alveolar echinococcosis, the course of metabolic activity in follow-up PET\/CT is associated to the course EgHF antibody levels. Both parameters may potentially be used to evaluate the course of the disease and potentially predict the duration of benzimidazole therapy.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0270695","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T17:31:01Z","timestamp":1656523861000},"page":"e0270695","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Follow-up PET\/CT of alveolar echinococcosis: Comparison of metabolic activity and immunodiagnostic testing"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5878-0818","authenticated-orcid":true,"given":"Lars","family":"Husmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6208-9694","authenticated-orcid":true,"given":"Ansgar","family":"Deibel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Skawran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Ledergerber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urs J.","family":"Muehlematter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Hasse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin W.","family":"Huellner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caecilia S.","family":"Reiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beat","family":"Muellhaupt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,6,29]]},"reference":[{"issue":"5","key":"pone.0270695.ref001","doi-asserted-by":"crossref","first-page":"506","DOI":"10.4269\/ajtmh.1990.43.506","article-title":"Recurrence rate after discontinuation of long-term mebendazole therapy in alveolar echinococcosis (preliminary results)","volume":"43","author":"RW Ammann","year":"1990","journal-title":"Am J Trop Med Hyg"},{"issue":"2","key":"pone.0270695.ref002","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/clinids\/15.2.234","article-title":"Parasiticidal effect of chemotherapy in alveolar hydatid disease: review of experience with mebendazole and albendazole in Alaskan Eskimos","volume":"15","author":"JF Wilson","year":"1992","journal-title":"Clin Infect Dis"},{"issue":"6","key":"pone.0270695.ref003","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/S0168-8278(98)80129-3","article-title":"Long-term mebendazole therapy may be parasitocidal in alveolar echinococcosis","volume":"29","author":"RW Ammann","year":"1998","journal-title":"J Hepatol"},{"issue":"3","key":"pone.0270695.ref004","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/hep.510250305","article-title":"Effect of albendazole on recurrent and residual alveolar echinococcosis of the liver after surgery","volume":"25","author":"H Ishizu","year":"1997","journal-title":"Hepatology"},{"issue":"3","key":"pone.0270695.ref005","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1002\/hep.1840190328","article-title":"Effect of chemotherapy on the larval mass and the long-term course of alveolar echinococcosis. 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