{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:36:43Z","timestamp":1792190203331,"version":"4.4.0"},"reference-count":14,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T00:00:00Z","timestamp":1656460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Purpose<\/jats:title>\n<jats:p>To evaluate whether the neutrophil-to-lymphocyte ratio (NLR) can predict the need for ureteral catheterization in patients with renal colic.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Materials and methods<\/jats:title>\n<jats:p>We retrospectively studied 15,887 patients with renal colic between 2005 and 2019. Patients with prior antibiotics treatment (156), with hematological diseases (15), with negative computerized tomography scan (CTS) for stone disease (473) or with no available laboratory findings (1750) were excluded. A ureteral double J stent (DJS) was inserted in case of ongoing pain, fever, sepsis, single kidney and elevated blood creatinine levels concomitant with hydronephrosis. A cut-off value of 2.1 NLR was determined to stratify and to compare patients using multivariable logistic regression models. A locally weighted scatterplot smoothing (LOWESS) plot was also applied to show the relationship between NLR and predicted probability for DJS insertion.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Thirteen-thousand and 493 patients with a mean age of 42.7 years (30% females and 70% males) were included in the study. Five-hundred and 57 patients (4.1%) underwent early DJS insertion: 5.3% vs. 1.5% of patients with high vs. low NLR, respectively, (<jats:italic>p<\/jats:italic>&lt;0.001). High NLR was significantly associated with longer hospitalization time, admission to the intensive care unit and overall mortality within a month from admission (<jats:italic>p<\/jats:italic>&lt;0.05). LOWESS plot showed that NLR value &gt;2.1 escalates progressively the probability for DJS insertion.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>A high NLR is associated with the need for early internal DJS insertion due to urolithiasis. The NLR is easily calculated from simple blood tests and based on our results can be used for clinical decision making in patients with renal colic needing renal decompression.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0270706","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T17:31:53Z","timestamp":1656523913000},"page":"e0270706","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Neutrophil to lymphocyte ratio as an early indicator for ureteral catheterization in patients with renal colic due to upper urinary tract lithiasis"],"prefix":"10.1371","volume":"17","author":[{"given":"Nimer","family":"Elsaraya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adi","family":"Gordon-Irshai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Schwarzfuchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Novack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2847-338X","authenticated-orcid":true,"given":"Nicola J.","family":"Mabjeesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4093-3457","authenticated-orcid":true,"given":"Endre Z.","family":"Neulander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,6,29]]},"reference":[{"key":"pone.0270706.ref001","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1016\/j.ajem.2019.06.013","article-title":"The relationship between the severity of pain and stone size, hydronephrosis and laboratory parameters in renal colic attack","volume":"37","author":"M\u0130 Sasmaz","year":"2019","journal-title":"Am J Emerg Med"},{"key":"pone.0270706.ref002","first-page":"7","article-title":"C-reactive protein to predict the need for surgical intervention in acute renal colic","author":"ST McSorley","year":"2014","journal-title":"J Clin Urol"},{"key":"pone.0270706.ref003","first-page":"76","article-title":"The value of C-reactive protein determination in patients with renal colic to decide urgent urinary diversion","author":"JC Angulo","year":"2010","journal-title":"Urology"},{"key":"pone.0270706.ref004","first-page":"24","article-title":"Inflammatory serum markers predicting spontaneous ureteral stone passage","author":"N Abou Heidar","year":"2020","journal-title":"Clin Exp Nephrol"},{"key":"pone.0270706.ref005","article-title":"The value of the neutrophil-lymphocyte count ratio in the diagnosis of sepsis in patients admitted to the Intensive Care Unit: A retrospective cohort study","author":"K Westerdijk","year":"2019","journal-title":"PLoS ONE"},{"key":"pone.0270706.ref006","first-page":"59","article-title":"Usefulness of neutrophil-lymphocyte ratio in young children with febrile urinary tract infection","author":"SY Han","year":"2016","journal-title":"Korean J Pediatr"},{"key":"pone.0270706.ref007","first-page":"12","article-title":"The association between neutrophil-to-lymphocyte count ratio and mortality in septic patients: A retrospective analysis of the MIMIC-III database","author":"W Ye","year":"2020","journal-title":"J Thorac Dis"},{"key":"pone.0270706.ref008","first-page":"98","article-title":"Neutrophil to lymphocyte ratio (NLR) as a prognostic marker for in-hospital mortality of patients with sepsis: A secondary analysis based on a single-center, retrospective, cohort study","author":"J Ni","year":"2019","journal-title":"Medicine (Baltimore)."},{"key":"pone.0270706.ref009","first-page":"37","article-title":"The neutrophil-lymphocyte count ratio as a diagnostic marker for bacteraemia: A systematic review and meta-analysis","author":"J Jiang","year":"2019","journal-title":"Am J Emerg Med"},{"key":"pone.0270706.ref010","first-page":"10","article-title":"What is the normal value of the neutrophil-to-lymphocyte ratio?","author":"P Forget","year":"2017","journal-title":"BMC Res Notes"},{"key":"pone.0270706.ref011","first-page":"58","article-title":"Significance of neutrophil-to-lymphocyte ratio as a novel indicator of spontaneous ureter stone passage","author":"KS Lee","year":"2017","journal-title":"Yonsei Med J."},{"key":"pone.0270706.ref012","first-page":"110","article-title":"Role of white blood cell and neutrophil counts in predicting spontaneous stone passage in patients with renal colic","author":"S Sfoungaristos","year":"2012","journal-title":"BJU Int"},{"key":"pone.0270706.ref013","first-page":"13","article-title":"Single emergency room measurement of neutrophil\/lymphocyte ratio for early detection of acute kidney injury (AKI)","author":"M Abu Alfeilat","year":"2018","journal-title":"Intern Emerg Med"},{"key":"pone.0270706.ref014","first-page":"25","article-title":"Are There standardized cutoff values for neutrophil-lymphocyte ratios in bacteremia or sepsis","author":"G Gurol","year":"2015","journal-title":"J Microbiol Biotechnol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0270706","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T17:32:13Z","timestamp":1656523933000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0270706"}},"subtitle":[],"editor":[{"given":"Jianhong","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,6,29]]},"references-count":14,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,6,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0270706","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,29]]}}}