{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T22:28:57Z","timestamp":1788474537634,"version":"build-2803163510"},"reference-count":23,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T00:00:00Z","timestamp":1658275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research Resettlement Fund for the new faculty of Seoul National University"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Purpose<\/jats:title>\n<jats:p>This study aimed to evaluate the correlation between tear film lipid layer thickness and transepidermal water loss (TEWL) from the ocular area in patients with short tear break-up time (TBUT)-type dry eye and healthy controls.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>This prospective study included 25 eyes of patients with short TBUT-type dry eye disease and 25 eyes of healthy controls.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Tear film lipid layer thickness was measured using an interferometer, and TEWL from the ocular area was measured using a Tewameter TM300 with custom-made goggles. The correlation between tear film lipid layer thickness and TEWL was evaluated. Additionally, other parameters such as TBUT, Schirmer I score, ocular surface staining, the presence and type of meibomian gland dysfunction (MGD), ocular surface disease index (OSDI), and visual analog scale (VAS) scores were evaluated. Tear film lipid layer thickness did not show a significant correlation with TEWL from the ocular area measured using a Tewameter TM300. However, tear film lipid layer thickness was significantly correlated with tear break-up time (p = 0.004) and ocular surface staining by NEI (National Eye Institute) scheme (p = 0.03). TEWL showed positive correlation with the Schirmer I score <jats:italic>(<\/jats:italic>p = 0.004).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The tear film lipid layer affected the stability of the tear film more than the amount of TEWL in patients with short TBUT dry eye and healthy controls.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0270810","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T17:34:54Z","timestamp":1658338494000},"page":"e0270810","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Correlation between tear film lipid layer thickness and transepidermal water loss from the ocular area in patients with dry eye disease and in healthy controls"],"prefix":"10.1371","volume":"17","author":[{"given":"Do Yeh","family":"Yoon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeon","family":"Hee Eun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3620-1536","authenticated-orcid":true,"given":"Joon Young","family":"Hyon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,7,20]]},"reference":[{"issue":"3","key":"pone.0270810.ref001","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jtos.2017.05.011","article-title":"TFOS DEWS II pathophysiology report.","volume":"15","author":"AJ Bron","year":"2017","journal-title":"Ocul Surf."},{"issue":"14","key":"pone.0270810.ref002","doi-asserted-by":"crossref","first-page":"DES64","DOI":"10.1167\/iovs.17-23746","article-title":"Short tear film breakup time-type dry eye","volume":"59","author":"Kazuo Tsubota","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"pone.0270810.ref003","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.exer.2003.09.019","article-title":"Functional aspects of the tear film lipid layer","volume":"78","author":"AJ Bron","year":"2004","journal-title":"Exp Eye Res"},{"issue":"4","key":"pone.0270810.ref004","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1167\/iovs.10-6997c","article-title":"The international workshop on meibomian gland dysfunction: report of the subcommittee on anatomy, physiology, and pathophysiology of the meibomian gland","volume":"52","author":"E Knop","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"10","key":"pone.0270810.ref005","first-page":"2942","article-title":"Tear evaporation from the ocular surface","volume":"33","author":"K Tsubota","year":"1992","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"11","key":"pone.0270810.ref006","doi-asserted-by":"crossref","first-page":"6022","DOI":"10.1118\/1.3495540","article-title":"Evaluation of tear evaporation from ocular surface by functional infrared thermography.","volume":"37","author":"J-H Tan","year":"2010","journal-title":"Med Phys."},{"issue":"2","key":"pone.0270810.ref007","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1167\/iovs.02-0170","article-title":"Tear evaporation dynamics in normal subjects and subjects with obstructive meibomian gland dysfunction","volume":"44","author":"E Goto","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"pone.0270810.ref008","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0014-4835(83)90086-6","article-title":"Tear evaporimeter for measuring water evaporation rate from the tear film under controlled conditions in humans","volume":"36","author":"M Rolando","year":"1983","journal-title":"Exp Eye Res"},{"issue":"11","key":"pone.0270810.ref009","doi-asserted-by":"crossref","first-page":"4831","DOI":"10.1167\/iovs.16-20109","article-title":"Assessment of transepidermal water loss from the ocular area in dry eye disease","volume":"57","author":"HS Jeon","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"pone.0270810.ref010","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1542-0124(12)70081-2","article-title":"The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007).","volume":"5","author":"MA Lemp","year":"2007","journal-title":"Ocul Surf"},{"issue":"4","key":"pone.0270810.ref011","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1167\/iovs.10-6997f","article-title":"The international workshop on meibomian gland dysfunction: report of the diagnosis subcommittee","volume":"52","author":"A Tomlinson","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"pone.0270810.ref012","first-page":"221","article-title":"Report of the national eye institute\/industry workshop on clinical trials in dry eyes.","volume":"21","author":"MA Lemp","year":"1995","journal-title":"CLAO J."},{"issue":"7","key":"pone.0270810.ref013","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1097\/ICO.0b013e318191b870","article-title":"The relationship between dry eye symptoms and lipid layer thickness","volume":"28","author":"CA Blackie","year":"2009","journal-title":"Cornea"},{"issue":"5","key":"pone.0270810.ref014","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.ophtha.2007.06.031","article-title":"Noncontact infrared meibography to document age-related changes of the meibomian glands in a normal population","volume":"115","author":"R Arita","year":"2008","journal-title":"Ophthalmology"},{"issue":"1","key":"pone.0270810.ref015","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/sj.eye.6700224","article-title":"Correlation of lipid layer thickness measurements with fluorescein tear film break-up time and Schirmer\u2019s test.","volume":"17","author":"MA Isreb","year":"2003","journal-title":"Eye (Lond)."},{"issue":"3","key":"pone.0270810.ref016","doi-asserted-by":"crossref","first-page":"e0230119","DOI":"10.1371\/journal.pone.0230119","article-title":"Relationship between lipid layer thickness, incomplete blinking rate and tear film instability in patients with different myopia degrees after small-incision lenticule extraction.","volume":"15","author":"Y Li","year":"2020","journal-title":"PLoS One"},{"issue":"2","key":"pone.0270810.ref017","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/ICO.0000000000001101","article-title":"Automated measurement of tear film dynamics and lipid layer thickness for assessment of non-sjogren dry eye syndrome with meibomian gland dysfunction","volume":"36","author":"YW Ji","year":"2017","journal-title":"Cornea"},{"issue":"10","key":"pone.0270810.ref018","doi-asserted-by":"crossref","first-page":"4076","DOI":"10.1167\/iovs.16-19251","article-title":"Analysis of factors associated with the tear film lipid layer thickness in normal eyes and patients with dry eye syndrome","volume":"57","author":"JW Jung","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"pone.0270810.ref019","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.survophthal.2007.04.009","article-title":"The correlation between the tear film lipid layer and dry eye disease.","volume":"52","author":"GN Foulks","year":"2007","journal-title":"Surv Ophthalmol"},{"issue":"3","key":"pone.0270810.ref020","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1167\/tvst.8.3.40","article-title":"Human Lacrimal Production Rate and Wetted Length of Modified Schirmer\u2019s Tear Test Strips.","volume":"8","author":"Andrew D. Graham Young Hyun Kim","year":"2019","journal-title":"Transl Vis Sci Technol."},{"issue":"2","key":"pone.0270810.ref021","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S1542-0124(12)70157-X","article-title":"Assessment of tear film dynamics: quantification approach.","volume":"3","author":"A Tomlinson","year":"2005","journal-title":"Ocul Surf."},{"key":"pone.0270810.ref022","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00006324-199701000-00014","article-title":"Importance of the lipid layer in human tear film stability and evaporation.","volume":"74","author":"JP Craig","year":"1997","journal-title":"Optom Vis Sci."},{"issue":"4","key":"pone.0270810.ref023","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1097\/ICL.0b013e3181a9d79d","article-title":"Tear and meibomian gland function in blepharitis and normals.","volume":"35","author":"LC McCann","year":"2009","journal-title":"Eye Contact Lens."}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0270810","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T17:35:17Z","timestamp":1658338517000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0270810"}},"subtitle":[],"editor":[{"given":"Timo","family":"Eppig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,7,20]]},"references-count":23,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,7,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0270810","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,20]]}}}