{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:39:35Z","timestamp":1791592775836,"version":"4.3.4"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T00:00:00Z","timestamp":1656979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Anemia adversely affects children\u2019s mental, physical and social development, particularly in Africa. In the early stages of life, it leads to severe negative consequences on the cognitive, growth and development of children.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Objective<\/jats:title>\n<jats:p>This study aimed to assess anemia and associated risk factors among children under-five years old in the West Guji Zone, southern Ethiopia, from October to November 2020.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Method<\/jats:title>\n<jats:p>A hospital-based quantitative cross-sectional study was conducted at Bule Hora General Hospital, Southern Ethiopia. A convenience sampling technique was used to include 375 under-five children enrolled in the study. The pretested structure questionnaire was used to collect socioeconomic and demographic characteristics of study individuals after taking appropriate written informed consent. Then, a venous blood sample was collected from each child and analyzed for hemoglobin determination using a Midray BC 3000 Plus machine. Binary logistic regression models were used to identify associated factors of anemia. A p-value \u2264 0.05 was considered statistically significant.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Result<\/jats:title>\n<jats:p>The overall prevalence of anemia among under-five children was 13.2% (50) [95% CI = 5.2\u201321.2%]. Among anemic children under-five years of age, 12% (6) had mild anemia, 32% (16) had moderate anemia and 56% (28) had severe anemia. In this study, anemia was significantly associated with a history of intestinal protozoan infection [AOR = 2.55, 95% CI = 1.28\u201310.42], malaria infection [AOR = 5.01, 95% CI = 0.18\u201311.44] and soil-transmitted helminths infection [AOR = 6.39, 95% CI = 1.75\u201329.08].<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The prevalence of anemia among under-five children was found to be low in the study area; however, the majority of anemic children were in a severe stage. It could be managed by preventing malaria infection, intestinal protozoa and soil-transmitted helminthic infection.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0270853","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T17:32:31Z","timestamp":1657042351000},"page":"e0270853","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Assessment of anemia and associated risk factors among children under-five years old in the West Guji Zone, southern Ethiopia: Hospital-based cross-sectional study"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7301-5332","authenticated-orcid":true,"given":"Alqeer","family":"Aliyo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdurezak","family":"Jibril","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,7,5]]},"reference":[{"issue":"4","key":"pone.0270853.ref001","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1017\/S1368980008002401","article-title":"Worldwide prevalence of anemia, WHO vitamin and mineral nutrition information system, 1993\u20132005","volume":"12","author":"E McLean","year":"2009","journal-title":"Public health nutrition"},{"issue":"15","key":"pone.0270853.ref002","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1056\/NEJMcpc049016","article-title":"Normal reference laboratory values","volume":"351","author":"A Kratz","year":"2004","journal-title":"New England Journal of Medicine"},{"key":"pone.0270853.ref003","volume-title":"Understanding anemia","author":"E. 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Addis Ababa, Ethiopia, and Rockville, Maryland, USA, 2017."},{"key":"pone.0270853.ref008","unstructured":"Knowledge SUCCESS. Anemia Prevalence, Causes, and Consequences. https:\/\/www.k4health.org\/toolkits\/anemia-prevention\/anemia-causes-prevalence-impact. [Accessed 5 Feb 2020]."},{"issue":"2","key":"pone.0270853.ref009","doi-asserted-by":"crossref","first-page":"100","DOI":"10.5581\/1516-8484.20110028","article-title":"Prevalence of anemia in under-five-year-old children in a children\u2019s hospital in Recife, Brazil","volume":"33","author":"RF Santos","year":"2011","journal-title":"Revista brasileira de hematologia e hemoterapia"},{"key":"pone.0270853.ref010","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4054\/DemRes.2001.5.4","article-title":"Attrition in longitudinal household survey data: some tests for three developing-country samples","volume":"5","author":"H Alderman","year":"2001","journal-title":"Demographic research"},{"issue":"2","key":"pone.0270853.ref011","doi-asserted-by":"crossref","first-page":"636S","DOI":"10.1093\/jn\/131.2.636S","article-title":"An analysis of anemia and child mortality","volume":"131","author":"BJ Brabin","year":"2001","journal-title":"The Journal of nutrition"},{"issue":"12","key":"pone.0270853.ref012","doi-asserted-by":"crossref","first-page":"e0190151","DOI":"10.1371\/journal.pone.0190151","article-title":"Prevalence of anemia and associated factors among school children in Gondar town public primary schools, northwest Ethiopia: A school-based cross-sectional study","volume":"12","author":"Z Getaneh","year":"2017","journal-title":"PloS one"},{"key":"pone.0270853.ref013","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/928632","article-title":"Factors associated with anemia among children aged 6\u201323 months attending growth monitoring at Tsitsika Health Center, Wag-Himra Zone, Northeast Ethiopia","volume":"2015","author":"H Woldie","year":"2015","journal-title":"Journal of nutrition and metabolism"},{"key":"pone.0270853.ref014","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1186\/s12887-021-03011-5","article-title":"Prevalence of anemia and its associated factors among under-five age children in Shanan gibe hospital, Southwest Ethiopia","volume":"21","author":"D. Kebede","year":"2021","journal-title":"BMC Pediatr"},{"key":"pone.0270853.ref015","first-page":"14652","article-title":"Prevalence of anemia and associated factor among under-five childern in Bedele Hospital, Iluababor Zone, Oromia Regional State South West Ethiopia","volume":"8","author":"B Abdisa","year":"2016","journal-title":"International Journal of Development Research"},{"key":"pone.0270853.ref016","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/7580104","article-title":"Magnitude, Severity, and Associated Factors of Anemia among Under-Five Children Attending Hawassa University Teaching and Referral Hospital, Hawassa, Southern Ethiopia, 2016","volume":"2020","author":"Y Gebereselassie","year":"2020","journal-title":"Anemia"},{"key":"pone.0270853.ref017","first-page":"208","volume-title":"Rodak\u2019s hematology: Clinical principles and applications","author":"S 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Gao","year":"2013","journal-title":"PloS one"},{"key":"pone.0270853.ref021","first-page":"33","article-title":"Iron deficiency anemia among children under three years in Kassala, Eastern Sudan","volume":"9","author":"H Mahmoud","year":"2014","journal-title":"Sudanese J Pub Heal"},{"issue":"4","key":"pone.0270853.ref022","first-page":"646","article-title":"Prevalence of anemia and associated factors among children below five years of age in Cape Verde, West Africa","volume":"32","author":"RM Semedo","year":"2014","journal-title":"Journal of health, population, and nutrition"},{"issue":"3","key":"pone.0270853.ref023","first-page":"31","article-title":"Malaria and anemia among children in a low resource setting in Nigeria","volume":"7","author":"BH Oladeinde","year":"2012","journal-title":"Iranian journal of parasitology"},{"issue":"1","key":"pone.0270853.ref024","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12878-015-0033-5","article-title":"Prevalence and factors 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