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Genomic deletion of the alpha globin gene (\n                      <jats:italic>HBA<\/jats:italic>\n                      ) is common among Black Americans and could lead to increased endothelial nitric oxide signaling and reduced risk of hypertension.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Community-dwelling US adults aged 45 years or older were enrolled and examined from 2003 to 2007, followed by telephone every 6 months, and reexamined from 2013 to 2016. At both visits, trained personnel performed standardized, in-home blood pressure measurements and pill bottle review. Prevalent hypertension was defined as systolic blood pressure \u2265 140mmHg or diastolic blood pressure \u2265 90mmHg or anti-hypertensive medication use. Droplet digital PCR was used to determine\n                      <jats:italic>HBA<\/jats:italic>\n                      copy number. The associations of\n                      <jats:italic>HBA<\/jats:italic>\n                      copy number with prevalent hypertension, resistant hypertension, and incident hypertension were estimated using multivariable regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 9,684 Black participants, 7,439 (77%) had hypertension at baseline and 1,044 of those had treatment-resistant hypertension. 1,000 participants were not hypertensive at baseline and participated in a follow up visit; 517 (52%) developed hypertension over median 9.2 years follow-up. Increased\n                      <jats:italic>HBA<\/jats:italic>\n                      copy number was not associated with prevalent hypertension (PR = 1.00; 95%CI 0.98,1.02), resistant hypertension (PR = 0.95; 95%CI 0.86,1.05), or incident hypertension (RR = 0.96; 95%CI 0.86,1.07).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      There were no associations between increased\n                      <jats:italic>HBA<\/jats:italic>\n                      copy number and risk of hypertension. These findings suggest that variation in alpha globin gene copy number does not modify the risk of hypertension among Black American adults.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0271031","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T13:27:26Z","timestamp":1657805246000},"page":"e0271031","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Alpha globin gene copy number and hypertension risk among Black Americans"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1583-4783","authenticated-orcid":true,"given":"A. 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