{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:07:25Z","timestamp":1785542845037,"version":"3.56.0"},"reference-count":59,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T00:00:00Z","timestamp":1657584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>\n                    While previous research using transcranial magnetic stimulation (TMS) suggest that cerebellum (CB) influences the neuroplastic response of primary motor cortex (M1), the role of different indirect (I) wave inputs in M1 mediating this interaction remains unclear. The aim of this study was therefore to assess how CB influences neuroplasticity of early and late I-wave circuits. 22 young adults (22 \u00b1 2.7 years) participated in 3 sessions in which I-wave periodicity repetitive transcranial magnetic stimulation (iTMS) was applied over M1 during concurrent application of cathodal transcranial direct current stimulation over CB (tDCS\n                    <jats:sub>\n                      <jats:italic>CB<\/jats:italic>\n                    <\/jats:sub>\n                    ). In each session, iTMS either targeted early I-waves (1.5 ms interval; iTMS\n                    <jats:sub>\n                      <jats:italic>1<\/jats:italic>\n                      .\n                      <jats:italic>5<\/jats:italic>\n                    <\/jats:sub>\n                    ), late I-waves (4.5 ms interval; iTMS\n                    <jats:sub>\n                      <jats:italic>4<\/jats:italic>\n                      .\n                      <jats:italic>5<\/jats:italic>\n                    <\/jats:sub>\n                    ), or had no effect (variable interval; iTMS\n                    <jats:sub>\n                      <jats:italic>Sham<\/jats:italic>\n                    <\/jats:sub>\n                    ). Changes due to the intervention were examined with motor evoked potential (MEP) amplitude using TMS protocols measuring corticospinal excitability (MEP\n                    <jats:sub>\n                      <jats:italic>1mV<\/jats:italic>\n                    <\/jats:sub>\n                    ) and the strength of CB-M1 connections (CBI). In addition, we indexed I-wave activity using short-interval intracortical facilitation (SICF) and low-intensity single-pulse TMS applied with posterior-anterior (MEP\n                    <jats:sub>\n                      <jats:italic>PA<\/jats:italic>\n                    <\/jats:sub>\n                    ) and anterior-posterior (MEP\n                    <jats:sub>\n                      <jats:italic>AP<\/jats:italic>\n                    <\/jats:sub>\n                    ) current directions. Following both active iTMS sessions, there was no change in MEP\n                    <jats:sub>\n                      <jats:italic>1mV<\/jats:italic>\n                    <\/jats:sub>\n                    , CBI or SICF (all\n                    <jats:italic>P<\/jats:italic>\n                    &gt; 0.05), suggesting that tDCS\n                    <jats:sub>\n                      <jats:italic>CB<\/jats:italic>\n                    <\/jats:sub>\n                    broadly disrupted the excitatory response that is normally seen following iTMS. However, although MEP\n                    <jats:sub>\n                      <jats:italic>AP<\/jats:italic>\n                    <\/jats:sub>\n                    also failed to facilitate after the intervention (\n                    <jats:italic>P<\/jats:italic>\n                    &gt; 0.05), MEP\n                    <jats:sub>\n                      <jats:italic>PA<\/jats:italic>\n                    <\/jats:sub>\n                    potentiated following both active iTMS sessions (both\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05). This differential response between current directions could indicate a selective effect of CB on AP-sensitive circuits.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0271311","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T16:04:41Z","timestamp":1657641881000},"page":"e0271311","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Cerebellar transcranial direct current stimulation disrupts neuroplasticity of intracortical motor circuits"],"prefix":"10.1371","volume":"17","author":[{"given":"Wei-Yeh","family":"Liao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoki","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Semmler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7771-7569","authenticated-orcid":true,"given":"George M.","family":"Opie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,7,12]]},"reference":[{"issue":"2","key":"pone.0271311.ref001","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s12311-015-0685-5","article-title":"The errors of our ways: understanding error representations in cerebellar-dependent motor learning","volume":"15","author":"LS Popa","year":"2016","journal-title":"Cerebellum"},{"issue":"1","key":"pone.0271311.ref002","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s12311-016-0763-3","article-title":"Consensus paper: towards a systems-level view of cerebellar function: the interplay between cerebellum, basal ganglia, and cortex","volume":"16","author":"D Caligiore","year":"2017","journal-title":"Cerebellum"},{"issue":"10","key":"pone.0271311.ref003","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1093\/cercor\/bhj087","article-title":"Effects of human cerebellar thalamus disruption on adaptive control of reaching","volume":"16","author":"H Chen","year":"2006","journal-title":"Cereb Cortex"},{"issue":"8","key":"pone.0271311.ref004","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1093\/cercor\/bhq246","article-title":"Dissociating the roles of the cerebellum and motor cortex during adaptive learning: the motor cortex retains what the cerebellum learns","volume":"21","author":"JM Galea","year":"2011","journal-title":"Cereb Cortex"},{"issue":"6","key":"pone.0271311.ref005","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/ana.410370603","article-title":"Magnetic stimulation over the cerebellum in humans","volume":"37","author":"Y Ugawa","year":"1995","journal-title":"Ann Neurol"},{"issue":"1","key":"pone.0271311.ref006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00221-003-1684-1","article-title":"Interactions between inhibitory and excitatory circuits in the human motor cortex","volume":"154","author":"R. 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