{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:17:26Z","timestamp":1747196246756,"version":"3.40.5"},"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:00:00Z","timestamp":1657756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>The relationship between bothersome symptoms and gastric pressure or CO<jats:sub>2<\/jats:sub> injection volumes in drug-resistant functional dyspepsia (FD) patients remains unknown; therefore, this relationship was examined in drug-resistant FD and non-FD patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Thirty drug-resistant FD patients and 30 non-FD patients were recruited. Gastric pressure was assessed using an external pressure transducer, and the CO<jats:sub>2<\/jats:sub> injection volume was measured using an endoscopic CO<jats:sub>2<\/jats:sub>-supplied device and flow meter. The following variables were examined: gastric pressure at baseline and gastric pressure and the CO<jats:sub>2<\/jats:sub> injection volume when patients initially felt abdominal tension and bothersome symptoms following the CO<jats:sub>2<\/jats:sub> injection. The relationship between belching and bothersome symptoms was also investigated.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>No significant differences were observed in basal gastric pressure between the groups. Initial and bothersome symptoms in the upper abdomen in drug-resistant FD patients developed at a significantly lower gastric pressure and significantly smaller CO<jats:sub>2<\/jats:sub> injection volume than in non-FD patients. The frequency of belching was significantly lower in the drug-resistant FD group than in the non-FD group.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Bothersome symptoms in drug-resistant FD patients develop at a lower gastric pressure and smaller CO<jats:sub>2<\/jats:sub> injection volume than in non-FD patients. These patients also had difficulties with belching.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0271456","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T17:38:14Z","timestamp":1657820294000},"page":"e0271456","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Smaller CO2 injection volume and lower gastric pressure induce bothersome symptoms in drug-resistant functional dyspepsia patients with less frequent 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