{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:53:03Z","timestamp":1792788783962,"version":"4.5.0"},"reference-count":62,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:00:00Z","timestamp":1658361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Pfizer Investigator-Initiated Research","award":["Award WS2049100"],"award-info":[{"award-number":["Award WS2049100"]}]},{"name":"Pfizer Investigator-Initiated Research","award":["Award WS2049100"],"award-info":[{"award-number":["Award WS2049100"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health\/NCI","doi-asserted-by":"crossref","award":["P01CA082834 and P01CA240685"],"award-info":[{"award-number":["P01CA082834 and P01CA240685"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health\/NCI","doi-asserted-by":"crossref","award":["P01CA082834 and P01CA240685"],"award-info":[{"award-number":["P01CA082834 and P01CA240685"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIH\/NIGMS","award":["R01GM129338 and R01CA230618"],"award-info":[{"award-number":["R01GM129338 and R01CA230618"]}]},{"name":"C Perelman and AJ Perelman endowments"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>\n                    Selective estrogen receptor modulators (SERMs), including the SERM\/SERD bazedoxifene (BZA), are used to treat postmenopausal osteoporosis and may reduce breast cancer (BCa) risk. One of the most persistent unresolved questions regarding menopausal hormone therapy is compromised control of proliferation and phenotype because of short- or long-term administration of mixed-function estrogen receptor (ER) ligands. To gain insight into epigenetic effectors of the transcriptomes of hormone and BZA-treated BCa cells, we evaluated a panel of histone modifications. The impact of short-term hormone treatment and BZA on gene expression and genome-wide epigenetic profiles was examined in ER\u03b1\n                    <jats:sup>neg<\/jats:sup>\n                    mammary epithelial cells (MCF10A) and ER\u03b1\n                    <jats:sup>+<\/jats:sup>\n                    luminal breast cancer cells (MCF7). We tested individual components and combinations of 17\u03b2-estradiol (E2), estrogen compounds (EC10) and BZA. RNA-seq for gene expression and ChIP-seq for active (H3K4me3, H3K4ac, H3K27ac) and repressive (H3K27me3) histone modifications were performed. Our results show that the combination of BZA with E2 or EC10 reduces estrogen-mediated patterns of histone modifications and gene expression in MCF-7\n                    <jats:sup>ER\u03b1+<\/jats:sup>\n                    cells. In contrast, BZA has minimal effects on these parameters in MCF10A mammary epithelial cells. BZA-induced changes in histone modifications in MCF7 cells are characterized by altered H3K4ac patterns, with changes at distal enhancers of ER\u03b1-target genes and at promoters of non-ER\u03b1 bound proliferation-related genes. Notably, the ER\u03b1 target gene\n                    <jats:italic>GREB1<\/jats:italic>\n                    is the most sensitive to BZA treatment. Our findings provide direct mechanistic-based evidence that BZA induces epigenetic changes in E2 and EC10 mediated control of ER\u03b1 regulatory programs to target distinctive proliferation gene pathways that restrain the potential for breast cancer development.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0271725","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T13:53:42Z","timestamp":1658411622000},"page":"e0271725","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Epigenetic and transcriptome responsiveness to ER modulation by tissue selective estrogen complexes in breast epithelial and breast cancer cells"],"prefix":"10.1371","volume":"17","author":[{"given":"Terri L.","family":"Messier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph R.","family":"Boyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A. R.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coralee E.","family":"Tye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie A.","family":"Page","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabail H.","family":"Toor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6664-5168","authenticated-orcid":true,"given":"Sayyed K.","family":"Zaidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry S.","family":"Komm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4058-3661","authenticated-orcid":true,"given":"Seth","family":"Frietze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2474-6822","authenticated-orcid":true,"given":"Janet L.","family":"Stein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane B.","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8762-5422","authenticated-orcid":true,"given":"Gary S.","family":"Stein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,7,21]]},"reference":[{"issue":"3","key":"pone.0271725.ref001","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1001\/jama.288.3.321","article-title":"Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women\u2019s Health Initiative randomized controlled trial","volume":"288","author":"JE Rossouw","year":"2002","journal-title":"JAMA"},{"issue":"4","key":"pone.0271725.ref002","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/gme.0b013e3181f43404","article-title":"Trends in menopausal hormone therapy use of US office-based physicians, 2000\u20132009.","volume":"18","author":"SA Tsai","year":"2011","journal-title":"Menopause"},{"key":"pone.0271725.ref003","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jsbmb.2014.03.003","article-title":"An overview of current and emerging SERMs","volume":"143","author":"BS Komm","year":"2014","journal-title":"The Journal of steroid biochemistry and molecular biology"},{"issue":"1","key":"pone.0271725.ref004","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.maturitas.2014.10.010","article-title":"Selective estrogen receptor modulators (SERMs): a review of clinical data.","volume":"80","author":"S Mirkin","year":"2015","journal-title":"Maturitas"},{"issue":"2","key":"pone.0271725.ref005","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.maturitas.2010.05.009","article-title":"SERMs: progress and future perspectives","volume":"67","author":"JH Pickar","year":"2010","journal-title":"Maturitas"},{"issue":"23","key":"pone.0271725.ref006","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.2174\/1381612023393404","article-title":"SERMs: evolutionary chemistry, revolutionary biology.","volume":"8","author":"CP Miller","year":"2002","journal-title":"Curr Pharm Des."},{"key":"pone.0271725.ref007","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.steroids.2014.06.004","article-title":"Development of conjugated estrogens\/bazedoxifene, the first tissue selective estrogen complex (TSEC) for management of menopausal hot flashes and postmenopausal bone loss.","volume":"90","author":"BS Komm","year":"2014","journal-title":"Steroids"},{"issue":"3","key":"pone.0271725.ref008","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1177\/2053369115599090","article-title":"Selective estrogen receptor modulators and the combination therapy conjugated estrogens\/bazedoxifene: A review of effects on the breast","volume":"21","author":"JH Pickar","year":"2015","journal-title":"Post Reprod Health"},{"issue":"9","key":"pone.0271725.ref009","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1158\/1078-0432.CCR-12-3771","article-title":"Bazedoxifene exhibits antiestrogenic activity in animal models of tamoxifen-resistant breast cancer: implications for treatment of advanced disease","volume":"19","author":"SE Wardell","year":"2013","journal-title":"Clin Cancer Res"},{"issue":"22","key":"pone.0271725.ref010","doi-asserted-by":"crossref","first-page":"5121","DOI":"10.1158\/1078-0432.CCR-15-0360","article-title":"Efficacy of SERD\/SERM Hybrid-CDK4\/6 Inhibitor Combinations in Models of Endocrine Therapy-Resistant Breast Cancer","volume":"21","author":"SE Wardell","year":"2015","journal-title":"Clin Cancer Res"},{"key":"pone.0271725.ref011","first-page":"7","article-title":"The SERM\/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells","author":"SW Fanning","year":"2018","journal-title":"Elife"},{"issue":"1\u20132","key":"pone.0271725.ref012","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jsbmb.2009.11.003","article-title":"Gene expression profiling studies of three SERMs and their conjugated estrogen combinations in human breast cancer cells: insights into the unique antagonistic effects of bazedoxifene on conjugated estrogens","volume":"118","author":"KC Chang","year":"2010","journal-title":"The Journal of steroid biochemistry and molecular biology"},{"issue":"2","key":"pone.0271725.ref013","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1177\/1933719112468834","article-title":"Tissue selective estrogen complexes (TSECs) and the future of menopausal therapy.","volume":"20","author":"HS Taylor","year":"2013","journal-title":"Reprod Sci"},{"issue":"3","key":"pone.0271725.ref014","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1677\/jme.0.0230255","article-title":"Nuclear receptors: coactivators, corepressors and chromatin remodeling in the control of transcription","volume":"23","author":"TN Collingwood","year":"1999","journal-title":"J Mol Endocrinol"},{"issue":"24","key":"pone.0271725.ref015","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1038\/sj.onc.1204329","article-title":"Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription","volume":"20","author":"FJ Dilworth","year":"2001","journal-title":"Oncogene"},{"issue":"9","key":"pone.0271725.ref016","doi-asserted-by":"crossref","first-page":"3802","DOI":"10.1158\/0008-5472.CAN-08-3907","article-title":"Global histone modifications in breast cancer correlate with tumor phenotypes, prognostic factors, and patient outcome","volume":"69","author":"SE Elsheikh","year":"2009","journal-title":"Cancer Res"},{"issue":"9","key":"pone.0271725.ref017","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/nrc2211","article-title":"Oestrogen-receptor-mediated transcription and the influence of co-factors and chromatin state","volume":"7","author":"KA Green","year":"2007","journal-title":"Nat Rev Cancer"},{"issue":"15","key":"pone.0271725.ref018","doi-asserted-by":"crossref","first-page":"3078","DOI":"10.4161\/cc.9.15.12516","article-title":"Reversibility of pre-malignant estrogen-induced epigenetic changes","volume":"9","author":"KR Kutanzi","year":"2010","journal-title":"Cell Cycle"},{"issue":"5","key":"pone.0271725.ref019","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S1043-2760(01)00392-7","article-title":"Nuclear receptors, coactivators and chromatin: new approaches, new insights","volume":"12","author":"KC Lee","year":"2001","journal-title":"Trends Endocrinol Metab"},{"issue":"3","key":"pone.0271725.ref020","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.3390\/cancers3021691","article-title":"Epigenetics of estrogen receptor signaling: role in hormonal cancer progression and therapy","volume":"3","author":"M Mann","year":"2011","journal-title":"Cancers (Basel)."},{"issue":"4","key":"pone.0271725.ref021","doi-asserted-by":"crossref","first-page":"e1001369","DOI":"10.1371\/journal.pgen.1001369","article-title":"Epigenetic regulation of cell type-specific expression patterns in the human mammary epithelium","volume":"7","author":"R Maruyama","year":"2011","journal-title":"PLoS Genetics"},{"issue":"17","key":"pone.0271725.ref022","doi-asserted-by":"crossref","first-page":"8061","DOI":"10.1093\/nar\/gkt586","article-title":"Estrogen represses gene expression through reconfiguring chromatin structures","volume":"41","author":"HU Osmanbeyoglu","year":"2013","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"pone.0271725.ref023","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1055\/s-0029-1237424","article-title":"Developmental origins of health and disease: brief history of the approach and current focus on epigenetic mechanisms.","volume":"27","author":"PD Wadhwa","year":"2009","journal-title":"Seminars in reproductive medicine."},{"issue":"1","key":"pone.0271725.ref024","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/PPO.0b013e31803c71f2","article-title":"Cancer susceptibility: epigenetic manifestation of environmental exposures.","volume":"13","author":"JR Weidman","year":"2007","journal-title":"Cancer journal"},{"issue":"1","key":"pone.0271725.ref025","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/em.20366","article-title":"Environmental epigenomics in human health and disease","volume":"49","author":"DC Dolinoy","year":"2008","journal-title":"Environmental and molecular mutagenesis"},{"issue":"Database issue","key":"pone.0271725.ref026","doi-asserted-by":"crossref","first-page":"D925","DOI":"10.1093\/nar\/gkn730","article-title":"Cell Line Data Base: structure and recent improvements towards molecular authentication of human cell lines","volume":"37","author":"P Romano","year":"2009","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"pone.0271725.ref027","doi-asserted-by":"crossref","first-page":"329","DOI":"10.11613\/BM.2014.035","article-title":"The many faces of estrogen signaling.","volume":"24","author":"P Vrtacnik","year":"2014","journal-title":"Biochem Med (Zagreb)."},{"issue":"3\u20135","key":"pone.0271725.ref028","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0960-0760(03)00360-1","article-title":"Sources of estrogen and their importance","volume":"86","author":"ER Simpson","year":"2003","journal-title":"The Journal of steroid biochemistry and molecular biology"},{"key":"pone.0271725.ref029","article-title":"Histone H3 lysine 4 acetylation and methylation dynamics define breast cancer subtypes","author":"TL Messier","year":"2016","journal-title":"Oncotarget"},{"issue":"1","key":"pone.0271725.ref030","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1210\/me.2008-0366","article-title":"Differential biochemical and cellular actions of Premarin estrogens: distinct pharmacology of bazedoxifene-conjugated estrogens combination","volume":"23","author":"TJ Berrodin","year":"2009","journal-title":"Mol Endocrinol"},{"issue":"5","key":"pone.0271725.ref031","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1093\/nar\/11.5.1475","article-title":"Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei","volume":"11","author":"JD Dignam","year":"1983","journal-title":"Nucleic Acids Res"},{"issue":"W1","key":"pone.0271725.ref032","doi-asserted-by":"crossref","first-page":"W3","DOI":"10.1093\/nar\/gkw343","article-title":"The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2016 update","volume":"44","author":"E Afgan","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"pone.0271725.ref033","volume-title":"Integrated Development for R.","author":"RStudio","year":"2015"},{"key":"pone.0271725.ref034","author":"S. Anders","year":"2010","journal-title":"FastQC: a quality control tool for high throughput sequence data"},{"issue":"1","key":"pone.0271725.ref035","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"A Dobin","year":"2013","journal-title":"Bioinformatics"},{"issue":"2","key":"pone.0271725.ref036","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq-a Python framework to work with high-throughput sequencing data","volume":"31","author":"S Anders","year":"2015","journal-title":"Bioinformatics"},{"issue":"D1","key":"pone.0271725.ref037","doi-asserted-by":"crossref","first-page":"D766","DOI":"10.1093\/nar\/gky955","article-title":"GENCODE reference annotation for the human and mouse genomes","volume":"47","author":"A Frankish","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"12","key":"pone.0271725.ref038","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"MI Love","year":"2014","journal-title":"Genome Biol"},{"issue":"9","key":"pone.0271725.ref039","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1038\/nprot.2012.101","article-title":"Identifying ChIP-seq enrichment using MACS.","volume":"7","author":"J Feng","year":"2012","journal-title":"Nat Protoc."},{"key":"pone.0271725.ref040","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/978-1-4939-0512-6_5","article-title":"Spatial clustering for identification of ChIP-enriched regions (SICER) to map regions of histone methylation patterns in embryonic stem cells.","volume":"1150","author":"S Xu","year":"2014","journal-title":"Methods Mol Biol"},{"issue":"1","key":"pone.0271725.ref041","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1101\/gr.139469.112","article-title":"GATA3 acts upstream of FOXA1 in mediating ESR1 binding by shaping enhancer accessibility","volume":"23","author":"V Theodorou","year":"2013","journal-title":"Genome Research"},{"issue":"4","key":"pone.0271725.ref042","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1093\/bioinformatics\/btz700","article-title":"hypeR: an R package for geneset enrichment workflows","volume":"36","author":"A Federico","year":"2020","journal-title":"Bioinformatics"},{"issue":"5","key":"pone.0271725.ref043","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"G Yu","year":"2012","journal-title":"Omics: a journal of integrative biology"},{"issue":"11","key":"pone.0271725.ref044","doi-asserted-by":"crossref","first-page":"e95","DOI":"10.1093\/nar\/gku351","article-title":"De novo detection of differentially bound regions for ChIP-seq data using peaks and windows: controlling error rates correctly","volume":"42","author":"AT Lun","year":"2014","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"pone.0271725.ref045","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/gkv1191","article-title":"csaw: a Bioconductor package for differential binding analysis of ChIP-seq data using sliding windows","volume":"44","author":"AT Lun","year":"2016","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"pone.0271725.ref046","doi-asserted-by":"crossref","first-page":"5094","DOI":"10.18632\/oncotarget.6922","article-title":"Histone H3 lysine 4 acetylation and methylation dynamics define breast cancer subtypes","volume":"7","author":"TL Messier","year":"2016","journal-title":"Oncotarget"},{"issue":"23","key":"pone.0271725.ref047","doi-asserted-by":"crossref","first-page":"36934","DOI":"10.18632\/oncotarget.17249","article-title":"RUNX1 and breast cancer","volume":"8","author":"J Mercado-Matos","year":"2017","journal-title":"Oncotarget"},{"issue":"10","key":"pone.0271725.ref048","doi-asserted-by":"crossref","first-page":"7261","DOI":"10.1002\/jcp.29625","article-title":"RUNX1 and RUNX2 transcription factors function in opposing roles to regulate breast cancer stem cells","volume":"235","author":"AJ Fritz","year":"2020","journal-title":"J Cell Physiol"},{"issue":"6","key":"pone.0271725.ref049","doi-asserted-by":"crossref","first-page":"5318","DOI":"10.1002\/jcp.29419","article-title":"Identification of tRNA-derived small RNA (tsRNA) responsive to the tumor suppressor, RUNX1, in breast cancer.","volume":"235","author":"NH Farina","year":"2020","journal-title":"J Cell Physiol"},{"issue":"12","key":"pone.0271725.ref050","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1158\/1541-7786.MCR-18-0135","article-title":"Suppression of Breast Cancer Stem Cells and Tumor Growth by the RUNX1 Transcription Factor","volume":"16","author":"D Hong","year":"2018","journal-title":"Mol Cancer Res"},{"issue":"26","key":"pone.0271725.ref051","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.18632\/oncotarget.27637","article-title":"Inhibition of the RUNX1-CBFbeta transcription factor complex compromises mammary epithelial cell identity: a phenotype potentially stabilized by mitotic gene bookmarking","volume":"11","author":"JT Rose","year":"2020","journal-title":"Oncotarget"},{"issue":"16","key":"pone.0271725.ref052","doi-asserted-by":"crossref","first-page":"3943","DOI":"10.1128\/MCB.00118-10","article-title":"Genome-wide analysis of estrogen receptor alpha DNA binding and tethering mechanisms identifies Runx1 as a novel tethering factor in receptor-mediated transcriptional activation","volume":"30","author":"JD Stender","year":"2010","journal-title":"Mol Cell Biol"},{"issue":"22","key":"pone.0271725.ref053","first-page":"6367","article-title":"PDZK1 and GREB1 are estrogen-regulated genes expressed in hormone-responsive breast cancer","volume":"60","author":"MG Ghosh","year":"2000","journal-title":"Cancer Res"},{"issue":"2","key":"pone.0271725.ref054","first-page":"342","article-title":"Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor","volume":"3","author":"H Mohammed","year":"2013","journal-title":"CellReports"},{"issue":"3","key":"pone.0271725.ref055","doi-asserted-by":"crossref","first-page":"T23","DOI":"10.1530\/JME-13-0227","article-title":"An evolving understanding of nuclear receptor coregulator proteins","volume":"51","author":"CJ Millard","year":"2013","journal-title":"J Mol Endocrinol"},{"issue":"40","key":"pone.0271725.ref056","doi-asserted-by":"crossref","first-page":"36865","DOI":"10.1074\/jbc.R100041200","article-title":"Coregulator codes of transcriptional regulation by nuclear receptors","volume":"276","author":"MG Rosenfeld","year":"2001","journal-title":"J Biol Chem"},{"key":"pone.0271725.ref057","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1146\/annurev-med-051812-145316","article-title":"Nuclear receptor coactivators: master regulators of human health and disease.","volume":"65","author":"S Dasgupta","year":"2014","journal-title":"Annual review of medicine"},{"issue":"1","key":"pone.0271725.ref058","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2217\/epi.12.74","article-title":"Histone lysine trimethylation or acetylation can be modulated by phytoestrogen, estrogen or anti-HDAC in breast cancer cell lines","volume":"5","author":"A Dagdemir","year":"2013","journal-title":"Epigenomics"},{"issue":"4","key":"pone.0271725.ref059","first-page":"291","article-title":"Epigenetic Modifications with DZNep, NaBu and SAHA in Luminal and Mesenchymal-like Breast Cancer Subtype Cells.","volume":"13","author":"A Dagdemir","year":"2016","journal-title":"Cancer genomics & proteomics"},{"issue":"1","key":"pone.0271725.ref060","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1038\/s41467-019-09320-9","article-title":"Temporal dynamic reorganization of 3D chromatin architecture in hormone-induced breast cancer and endocrine resistance","volume":"10","author":"Y Zhou","year":"2019","journal-title":"Nat Commun"},{"issue":"3","key":"pone.0271725.ref061","doi-asserted-by":"crossref","first-page":"e1001354","DOI":"10.1371\/journal.pgen.1001354","article-title":"H3 lysine 4 is acetylated at active gene promoters and is regulated by H3 lysine 4 methylation.","volume":"7","author":"B Guillemette","year":"2011","journal-title":"PLoS Genetics."},{"issue":"7","key":"pone.0271725.ref062","first-page":"1722","article-title":"Enhancer Activity Requires CBP\/P300 Bromodomain-Dependent Histone H3K27 Acetylation.","volume":"24","author":"R Raisner","year":"2018","journal-title":"CellReports."}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0271725","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T13:55:02Z","timestamp":1658411702000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0271725"}},"subtitle":[],"editor":[{"given":"Gokul M.","family":"Das","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,7,21]]},"references-count":62,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,7,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0271725","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,21]]}}}