{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:17:52Z","timestamp":1747196272425,"version":"3.40.5"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T00:00:00Z","timestamp":1658966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objectives<\/jats:title>\n<jats:p>To assess the usability of German hospital administrative claims data (GHACD) to determine inpatient management patterns, healthcare resource utilization, and quality-of-care in patients with multiple myeloma (PwMM).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Based on German tertiary hospital\u2019s claims data (2015\u20132017), PwMM aged &gt;18 years were included if they had an International Classification of Diseases, Tenth Revision, code of C90.0 or received anti-MM therapy. Subgroup analysis was performed on stem cell transplantation (SCT) patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Of 230 PwMM, 59.1% were men; 56.1% were aged \u226565 years. Hypertension and infections were present in 50% and 67.0%, respectively. Seventy percent of PwMM received combination therapy. Innovative drugs such as bortezomib and lenalidomide were given to 36.1% and 10.9% of the patients, respectively. Mean number of admissions and mean hospitalization length\/patient were 3.69 (standard deviation (SD) 2.71 (1\u201316)) and 12.52 (SD 9.55 (1\u201368.5)) days, respectively. In-hospital mortality was recorded in 12.2%. Seventy-two percent of SCT patients (n = 88) were aged \u226465 years, 22.7% required second transplantation, and 89.8% received platelet transfusion at a mean of 1.42(SD 0.63 (1\u20133)).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>GHACD provided relevant information essential for healthcare studies about PwMM from routine care settings. Data fundamental for quality-of-care assessment were also captured.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0271754","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T17:57:27Z","timestamp":1659031047000},"page":"e0271754","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Usability of German hospital administrative claims data for healthcare research: General assessment and use case of multiple myeloma in Munich university hospital in 2015\u20132017"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3344-2983","authenticated-orcid":true,"given":"Amal","family":"AlZahmi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irena","family":"Cenzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9955-8906","authenticated-orcid":true,"given":"Ulrich","family":"Mansmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"Ostermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Theurich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Schleinkofer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Berger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2022,7,28]]},"reference":[{"issue":"1","key":"pone.0271754.ref001","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1185\/03007995.2015.1105202","article-title":"Real-world treatment patterns, comorbidities, and disease-related complications in patients with multiple myeloma in the United States.","volume":"32","author":"X Song","year":"2016","journal-title":"Curr Med Res Opin"},{"issue":"9","key":"pone.0271754.ref002","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1038\/leu.2016.380","article-title":"Trends in overall survival and costs of multiple myeloma, 2000\u20132014","volume":"31","author":"R Fonseca","year":"2017","journal-title":"Leukemia"},{"key":"pone.0271754.ref003","article-title":"Health Care Costs and Resource Utilization, Including Patient Burden, Associated With Novel-Agent-Based Treatment Versus Other Therapies for Multiple Myeloma: Findings Using Real-World Claims Data","author":"A Teitelbaum","year":"2013","journal-title":"Oncologist"},{"key":"pone.0271754.ref004","article-title":"Administrative Data from Germany\u2019s Statutory Health Insurances for Social, Economic and Medical Research","author":"G. Heller","year":"2009","journal-title":"German Council for Social and Economic Data (RatSWD)"},{"issue":"5","key":"pone.0271754.ref005","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s10198-016-0849-3","article-title":"Access, use, and challenges of claims data analyses in Germany.","volume":"18","author":"S Neubauer","year":"2017","journal-title":"Eur J Heal Econ"},{"issue":"43","key":"pone.0271754.ref006","doi-asserted-by":"crossref","first-page":"4846","DOI":"10.3748\/wjg.v24.i43.4846","article-title":"Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes","volume":"24","author":"A McGuigan","year":"2018","journal-title":"World J Gastroenterol"},{"issue":"1","key":"pone.0271754.ref007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/00019053-199916010-00001","article-title":"Using Healthcare Claims Data for Outcomes Research and Pharmacoeconomic Analyses CURRENT OPINION","volume":"16","author":"HG Birnbaum","year":"1999","journal-title":"Pharmacoeconomics"},{"issue":"1","key":"pone.0271754.ref008","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1017\/S0266462316000131","article-title":"Using claims data for evidence generation in managed entry agreements","volume":"32","author":"A Brandes","year":"2016","journal-title":"Int J Technol Assess Health Care"},{"issue":"1","key":"pone.0271754.ref009","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/s12913-018-3080-3","article-title":"Health economic evaluations based on routine data in Germany: a systematic review.","volume":"18","author":"FM Gansen","year":"2018","journal-title":"BMC Health Serv Res [Internet]."},{"key":"pone.0271754.ref010","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/bmt.2012.133","article-title":"Costs of autologous and allogeneic hematopoietic cell transplantation in the United States: a study using a large National Private Claims Database","volume":"48","author":"NS Majhail","year":"2012","journal-title":"Bone Marrow Transplant"},{"key":"pone.0271754.ref011","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1016\/j.bbmt.2016.05.005","article-title":"Administrative Claims Data for Economic Analyses in Hematopoietic Cell Transplantation","volume":"22","author":"JM Preussler","year":"2016","journal-title":"Challenges and Opportunities. Biol Blood Marrow Transplant"},{"key":"pone.0271754.ref012","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.lungcan.2015.09.005","article-title":"Cost-components of lung cancer care within the first three years after initial diagnosis in context of different treatment regimens","volume":"90","author":"L Schwarzkopf","year":"2015","journal-title":"Lung Cancer"},{"key":"pone.0271754.ref013","unstructured":"Datenlieferung gem. \u00a7 21 KHEntgG, InEK GmbH [Internet]. [cited 2020 Feb 13]. Available from: https:\/\/www.g-drg.de\/Datenlieferung_gem._21_KHEntgG"},{"issue":"2","key":"pone.0271754.ref014","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.healthpol.2016.01.007","article-title":"Status and perspectives of claims data analyses in Germany-A systematic review","volume":"120","author":"K Kreis","year":"2016","journal-title":"Health Policy (New York)."},{"key":"pone.0271754.ref015","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/ejh.13523","article-title":"Changes in treatment landscape of relapsed or refractory multiple myeloma and their association with mortality: Insights from German claims database","volume":"106","author":"C Scheid","year":"2020","journal-title":"Eur J Haematol"},{"issue":"1","key":"pone.0271754.ref016","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12883-019-1556-3","article-title":"Epidemiology and health care utilization of patients suffering from Huntington\u2019s disease in Germany: Real world evidence based on German claims data","volume":"19","author":"C Ohlmeier","year":"2019","journal-title":"BMC Neurol"},{"key":"pone.0271754.ref017","unstructured":"Healthcare Financial Management Association. Costing healthcare in Germany. 2015; Available from: www.hfma.org.uk"},{"issue":"1","key":"pone.0271754.ref018","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00005650-199801000-00004","article-title":"Comorbidity Measures for Use with Administrative Data.","volume":"36","author":"A Elixhauser","year":"1998","journal-title":"Med Care"},{"key":"pone.0271754.ref019","article-title":"Comparing routine administrative data with registry data for assessing quality of hospital care in patients with myocardial infarction using deterministic record linkage.","author":"B Maier","year":"2016","journal-title":"BMC Health Serv Res [Internet]"},{"key":"pone.0271754.ref020","doi-asserted-by":"crossref","first-page":"iv52","DOI":"10.1093\/annonc\/mdx096","article-title":"Multiple myeloma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.","volume":"28","author":"P Moreau","year":"2017","journal-title":"Ann Oncol."},{"issue":"3","key":"pone.0271754.ref021","doi-asserted-by":"crossref","first-page":"225","DOI":"10.4065\/mcp.2009.0426","article-title":"Patterns of multiple myeloma during the past 5 decades: Stable incidence rates for all age groups in the population but rapidly changing age distribution in the clinic","volume":"85","author":"I Turesson","year":"2010","journal-title":"Mayo Clin Proc"},{"issue":"1","key":"pone.0271754.ref022","first-page":"470","article-title":"The Diagnosis and Treatment of Multiple Myeloma.","author":"C Gerecke","year":"2016","journal-title":"Dtsch Aerzteblatt Online"},{"issue":"2","key":"pone.0271754.ref023","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/bjh.13537","article-title":"Trends in survival of multiple myeloma patients in Germany and the United States in the first decade of the 21st century","volume":"171","author":"D Pulte","year":"2015","journal-title":"Br J Haematol"},{"issue":"11","key":"pone.0271754.ref024","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.ejca.2005.11.040","article-title":"State of the art therapy in multiple myeloma and future perspectives","volume":"42","author":"U Denz","year":"2006","journal-title":"Eur J Cancer"},{"issue":"3","key":"pone.0271754.ref025","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/j.1365-2354.2009.01153.x","article-title":"Healthcare costs of multiple myeloma: An Italian study","volume":"20","author":"D Koleva","year":"2011","journal-title":"Eur J Cancer Care (Engl)."},{"issue":"6","key":"pone.0271754.ref026","doi-asserted-by":"crossref","first-page":"5043","DOI":"10.3892\/ol.2016.5375","article-title":"Diagnostic and therapeutic approaches to multiple myeloma patients: \u2018Real-world\u2019 data from representative multicentre treatment surveys in Germany between 2008 and 2011","volume":"12","author":"TM Moehler","year":"2016","journal-title":"Oncol Lett"},{"issue":"6","key":"pone.0271754.ref027","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1007\/s00277-017-2991-0","article-title":"Diagnosis and treatment of multiple myeloma in Germany: analysis of a nationwide multi-institutional survey","volume":"96","author":"M Merz","year":"2017","journal-title":"Ann Hematol"},{"issue":"2","key":"pone.0271754.ref028","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/bjh.14213","article-title":"Multiple myeloma: patient outcomes in real-world practice","volume":"175","author":"K Yong","year":"2016","journal-title":"Br J Haematol"},{"issue":"10","key":"pone.0271754.ref029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pmed.1001885","article-title":"The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) Statement","volume":"12","author":"EI Benchimol","year":"2015","journal-title":"PLoS Med"},{"issue":"12","key":"pone.0271754.ref030","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1002\/pds.4266","article-title":"Identifying cancer drug regimens in French health insurance database: An application in multiple myeloma patients","volume":"26","author":"A Palmaro","year":"2017","journal-title":"Pharmacoepidemiol Drug Saf"},{"issue":"7","key":"pone.0271754.ref031","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.clinthera.2018.05.017","article-title":"Treatment Outcomes and Health Care Resource Utilization in Patients With Newly Diagnosed Multiple Myeloma Receiving Lenalidomide-only Maintenance, Any Maintenance, or No Maintenance: Results from the Connect MM Registry","volume":"40","author":"RM Rifkin","year":"2018","journal-title":"Clin Ther."},{"issue":"1","key":"pone.0271754.ref032","doi-asserted-by":"crossref","first-page":"IJH05","DOI":"10.2217\/ijh-2018-0004","article-title":"Chart review across EU5 in MM post-ASCT patients","volume":"7","author":"J Ashcroft","year":"2018","journal-title":"Int J Hematol Oncol"},{"key":"pone.0271754.ref033","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2147\/JBM.S234374","article-title":"Platelet transfusion: And update on challenges and outcomes","volume":"11","author":"PS Alcaina","year":"2020","journal-title":"J Blood Med"},{"key":"pone.0271754.ref034","unstructured":"ICD-11\u2014Mortality and Morbidity Statistics [Internet]. [cited 2019 Dec 7]. Available from: https:\/\/icd.who.int\/browse11\/l-m\/en#\/http%3A%2F%2Fid.who.int%2Ficd%2Fentity%2F1153296343"},{"issue":"1","key":"pone.0271754.ref035","first-page":"39","article-title":"Temporal Trends in Survival and Healthcare Costs in Patients with Multiple Myeloma in the United States","volume":"11","author":"EM Maise","year":"2018","journal-title":"Am Heal Drug Benefit"},{"key":"pone.0271754.ref036","doi-asserted-by":"crossref","first-page":"606154","DOI":"10.1100\/2012\/606154","article-title":"Benchmarking strategies for measuring the quality of healthcare: Problems and prospects.","volume":"2012","author":"PG Lovaglio","year":"2012","journal-title":"Sci World J"},{"issue":"S 01","key":"pone.0271754.ref037","doi-asserted-by":"crossref","first-page":"e50","DOI":"10.3414\/ME18-03-0003","article-title":"German Medical Informatics Initiative.","volume":"57","author":"SC Semler","year":"2018","journal-title":"Methods Inf Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0271754","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T17:58:05Z","timestamp":1659031085000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0271754"}},"subtitle":[],"editor":[{"given":"Isabelle","family":"Durand-Zaleski","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,7,28]]},"references-count":37,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,7,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0271754","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2022,7,28]]}}}