{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T07:49:10Z","timestamp":1789285750846,"version":"build-2803163510"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:00:00Z","timestamp":1658361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>The insulin-like growth factor 1 (<jats:italic>IGF1<\/jats:italic>) gene is located within the myopia-associated MYP3 interval, which suggests it may play an important role in the progression of myopia. However, the association between <jats:italic>IGF1<\/jats:italic> SNPs and any myopia is rarely reported.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>A comprehensive literature search was conducted on studies published up to July 22, 2021 in PubMed, EMBASE, CBM, COCHRANE, CNKI, WANFANG and VIP databases. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for single-nucleotide polymorphisms (SNPs) that have been evaluated in at least three studies.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Nine studies involving 4596 subjects with any myopia and 4950 controls examined 25 SNPs in <jats:italic>IGF1<\/jats:italic> gene, among which seven SNPs were included in this meta-analysis. Significant associations were not found in any genetic models between rs6214, rs12423791, rs5742632, rs10860862, rs5742629 and any myopia. Rs2162679 was suggestively associated with any myopia in the codominant model (GA vs. AA: OR = 0.87, 95% CI: 0.76\u20131.00) and the dominant model (GG+GA vs. AA: OR = 0.88, 95% CI = 0.78\u20131.00).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Meta-analysis of updated data reveals that the G allele of the <jats:italic>IGF1<\/jats:italic> rs2162679 SNP is a potential protective factor for any myopia, which is worth further researches.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0271809","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T17:40:43Z","timestamp":1658425243000},"page":"e0271809","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["The G allele of the IGF1 rs2162679 SNP is a potential protective factor for any myopia: Updated systematic review and meta-analysis"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8243-6216","authenticated-orcid":true,"given":"Bo","family":"Meng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2549-9552","authenticated-orcid":true,"given":"Yingxiang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,7,21]]},"reference":[{"issue":"12","key":"pone.0271809.ref001","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1001\/archophthalmol.2009.303","article-title":"Increased prevalence of myopia in the United States between 1971\u20131972 and 1999\u20132004","volume":"127","author":"S Vitale","year":"2009","journal-title":"Arch Ophthalmol"},{"issue":"7","key":"pone.0271809.ref002","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/j.ophtha.2015.03.018","article-title":"Increasing Prevalence of Myopia in Europe and the Impact of Education","volume":"122","author":"KM Williams","year":"2015","journal-title":"Ophthalmology"},{"key":"pone.0271809.ref003","first-page":"62134","article-title":"The epidemics of myopia: Aetiology and prevention","author":"IG Morgan","year":"2018","journal-title":"Progress in retinal and eye research"},{"issue":"9827","key":"pone.0271809.ref004","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1016\/S0140-6736(12)60272-4","article-title":"Myopia","volume":"379","author":"IG Morgan","year":"2012","journal-title":"Lancet"},{"issue":"1","key":"pone.0271809.ref005","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12886-019-1281-0","article-title":"Prevalence of myopia and vision impairment in school students in Eastern China","volume":"20","author":"J Wang","year":"2020","journal-title":"BMC ophthalmology"},{"issue":"6","key":"pone.0271809.ref006","first-page":"602","article-title":"Epidemiology of myopia and prevention of myopia progression in children in East Asia: a review.","volume":"24","author":"CY Mak","year":"2018","journal-title":"Hong Kong medical journal = Xianggang yi xue za zhi"},{"issue":"12","key":"pone.0271809.ref007","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/j.ophtha.2019.06.025","article-title":"The Increasing Burden of Myopia in Israel among Young Adults over a Generation: Analysis of Predisposing Factors","volume":"126","author":"Y Shapira","year":"2019","journal-title":"Ophthalmology"},{"issue":"12","key":"pone.0271809.ref008","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1097\/IAE.0000000000001489","article-title":"Overview Of the Complications Of High Myopia","volume":"37","author":"Y. 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