{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:47:30Z","timestamp":1791290850466,"version":"4.3.0"},"reference-count":23,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T00:00:00Z","timestamp":1658966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Background<\/jats:title><jats:p>Nutritional care during the neonatal period is a cornerstone towards achieving optimal care. However, very limited data is available on optimizing parenteral and enteral nutrition that directly affects infant survival among Ethiopian neonates. Therefore, the objective of this study is to identify determinants of time to full enteral feeding achievement among low-birth-weight neonates admitted to neonatal intensive care units of public hospitals in Hawassa city.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Methods<\/jats:title><jats:p>A facility-based retrospective cohort study was conducted in Adare general hospital and Hawassa University\u2019s comprehensive specialized hospital from August 2018 to 2019. Charts of infants with a birth weight of 1000-2000g (n = 273) neonates who were admitted to the neonatal intensive care unit (ICU) were reviewed. The sample size for each hospital was allocated proportionally and subjects were selected by using a simple random sampling technique. Data were entered using Epi. data version 3.1, and analysis was performed using SPSS version 20. Kaplan-Meier estimator and a Cox proportional hazard model were used.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Result<\/jats:title><jats:p>The mean (SD) age when an enteral feed (trophic feeding) was first commenced was 2.13(1.373) days. The median time to achieve full enteral feeding was 8 days with IQR (7\u201310 days). Gestational age reduces the time to full enteral feeding by 18.8% for each additional week of gestation (AHR = 0.812, p-value = 0.003). The time to achieve full enteral feeding was shorter by 70.4% among neonates who were small for gestational age, as compared with that appropriate for gestational age (AHR = 0.296, p-value&lt;0.001).<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Conclusion<\/jats:title><jats:p>According to this study, the time that the neonate takes to achieve full enteral feeding was relatively short. Gestational age and weight for gestational were the determinants for time to full enteral feeding achievement. Further research needs to be conducted to explore further, in addition to current findings.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0271963","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T17:47:47Z","timestamp":1659030467000},"page":"e0271963","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Determinants of time to full enteral feeding achievement among infants with birth weight 1000-2000g admitted to the neonatal intensive care unit of public hospitals in Hawassa city, Sidama region Ethiopian, 2019: A retrospective cohort study"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6841-0055","authenticated-orcid":true,"given":"Melese Tikusie","family":"Tewoldie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meron","family":"Girma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haider","family":"Seid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,7,28]]},"reference":[{"key":"pone.0271963.ref001","author":"S Basis","year":"2014","journal-title":"Nutritional Care of Preterm Infants"},{"issue":"January","key":"pone.0271963.ref002","first-page":"1","article-title":"Factors Associated with Time to Full Feeds in Preterm Very Low Birth Weight Infants","volume":"0","author":"G Patwardhan","year":"2018","journal-title":"J of tropical Pediatr."},{"key":"pone.0271963.ref003","volume-title":"Guidelines on Optimal Feeding of Low Birth-Weight Infants in Low- and Middle-Income Countries [Internet]","author":"Who","year":"2011"},{"key":"pone.0271963.ref004","first-page":"438","volume-title":"J Perinatol [Internet]","author":"KM Edmond","year":"2008"},{"issue":"9","key":"pone.0271963.ref005","doi-asserted-by":"crossref","first-page":"e45 LP","DOI":"10.1542\/pir.20.9.e45","article-title":"Early Aggressive Nutrition in the Neonate","volume":"20","author":"PJ Thureen","year":"1999","journal-title":"Pediatr Rev [Internet]"},{"issue":"21","key":"pone.0271963.ref006","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1080\/14767058.2016.1256992","article-title":"In resource-limited areas complete enteral feed in stable very low birth weight infants (1000\u20131500\u2009g) started within 24\u2009h of life can improve nutritional outcomes","volume":"30","author":"R Bora","year":"2017","journal-title":"J Matern Neonatal Med [Internet]. 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Gupte","year":"2016","journal-title":"EC Paediatr."},{"issue":"2","key":"pone.0271963.ref016","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1093\/tropej\/fmx038","article-title":"Postnatal weight gain patterns in preterm very-low-birth-weight infants born in a tertiary care center in South India","volume":"64","author":"G Mathew","year":"2018","journal-title":"J Trop Pediatr"},{"issue":"3","key":"pone.0271963.ref017","article-title":"Survival Analysis of Under-Five Mortality of Children and its Associated Risk Factors in Ethiopia","volume":"7","author":"Y Getachew","year":"2016","journal-title":"J Biosens Bioelectron"},{"issue":"1","key":"pone.0271963.ref018","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1651-2227.2009.01519.x","article-title":"Slow versus rapid enteral feeding advancement in preterm newborn infants 1000\u20131499 g: a randomized controlled trial","volume":"99","author":"S Krishnamurthy","year":"2010","journal-title":"Acta Paediatr. 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