{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:17:20Z","timestamp":1791065840453,"version":"4.1.0"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["442551\/2019-3"],"award-info":[{"award-number":["442551\/2019-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"\n Background<\/jats:title>\n Cerebral palsy is an extremely severe brain injury associated with multiple nutritional and clinical issues, such as underweight, gastroesophageal reflux, constipation, and nutrient deficiency. Evidence-based dietary and nutritional interventions may improve the quality of life of children with cerebral palsy.<\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n Systematically review randomized clinical trials evaluating nutritional and dietary interventions in the clinical, nutritional, and neurodevelopmental aspects of children with cerebral palsy.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A search was performed in electronic databases (LILACS, Medline, Web of Science, Embase, Scopus, Cochrane Library, ClinicalTrials.gov, Brazilian Digital Library of Theses and Dissertations, ProQuest Dissertations and Theses Database, OpenGrey) using keywords. The search was firstly performed in May 2020 and updated on June 18th, 2021. Eligible studies were randomized clinical trials, that included children between 2 and 12 years old, and evaluated the effect of nutritional or dietetic interventions on clinical, nutritional or neurodevelopmental outcomes. Risk of bias was investigated using the RoB-2 tool. The study was registered on PROSPERO (CRD42020181284).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Fifteen studies were selected. Positive results included the use of whey-based or pectin-enriched enteral formulas for gastroesophageal reflux (n = 6); 25-hydroxy-vitamin D supplementation for hypovitaminosis D (n = 2); supplementation with lipid mixture or diet with high-density energy for improvements in anthropometric measures (n = 2); supplementation with probiotics, prebiotics, symbiotics or magnesium for constipation (n = 2); nutritional support system for gross motor function (n = 1); lactoferrin and iron hydroxide polymaltose for iron deficiency anemia (n = 1); and educational intervention to improve feeding skills (n = 1). The overall risk of bias was high for 60% of the studies, and some concerns were raised for the remaining 40%.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Some promising dietary and nutritional interventions may promote important clinical improvements for patients with cerebral palsy. However, evidence is weak, as few clinical trials have been published with many methodological errors, leading to a high risk of bias.<\/jats:p>\n <\/jats:sec>","DOI":"10.1371\/journal.pone.0271993","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T13:38:18Z","timestamp":1658497098000},"page":"e0271993","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Dietary and nutritional interventions in children with cerebral palsy: A systematic literature review"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6207-5161","authenticated-orcid":true,"given":"Fernanda","family":"Rebelo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela Rodrigues","family":"Mansur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa Cristina","family":"Miglioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Dalva Baker","family":"Meio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1554-943X","authenticated-orcid":true,"given":"Saint Clair Gomes","family":"Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,7,22]]},"reference":[{"key":"pone.0271993.ref001","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1017\/S0012162200001511","article-title":"Surveillance of cerebral palsy in Europe: a collaboration of cerebral palsy surveys and registers. 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Preliminary randomised controlled study","volume":"86","author":"C Le Roy","year":"2015","journal-title":"Rev Chil Pediatr"},{"key":"pone.0271993.ref008","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1016\/j.jpeds.2012.11.053","article-title":"Selected macro\/micronutrient needs of the routine preterm infant","volume":"162","author":"J Bhatia","year":"2013","journal-title":"J Pediatr"},{"key":"pone.0271993.ref009","article-title":"Biomarkers of Nutrition for Development (BOND)-Zinc Review","author":"JC King","year":"2016","journal-title":"J Nutr"},{"key":"pone.0271993.ref010","doi-asserted-by":"crossref","unstructured":"Garcia-Contreras AA, Vasquez-Garibay EM, Sanchez-Ramirez CA, Fafutis-Morris M, Delgado-Rizo V. Lactobacillus reuteri DSM 17938 and Agave Inulin in Children with Cerebral Palsy and Chronic Constipation: A Double-Blind Randomized Placebo Controlled Clinical Trial. NUTRIENTS. 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