{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:21:14Z","timestamp":1777674074588,"version":"3.51.4"},"reference-count":66,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T00:00:00Z","timestamp":1660176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007861","name":"University of Gondar","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007861","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>COVID-19 is a viral disease caused by a new strain of corona virus. Currently, prognosis and risk stratification of COVID-19 patients is done by the disease\u2019s clinical presentation. Therefore, identifying laboratory biomarkers for disease prognosis and risk stratification of COVID-19 patients is critical for prompt treatment. Therefore, the main objective of this study was to assess the risk stratification and prognostic value of basic coagulation parameters and factors associated with disease severity among COVID-19 patients at the Tibebe Ghion Specialized Hospital, COVID-19 treatment center, Northwest Ethiopia.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>A follow-up study was conducted among conveniently recruited COVID-19 patients attended from March to June 2021. Socio-demographic and clinical data were collected using a structured questionnaire and checklist, respectively. Prothrombin time (PT) and activated partial thromboplastin time (APTT) were analyzed by the HUMACLOT DUE PLUS<jats:sup>\u00ae<\/jats:sup> machine. Descriptive statistics were used to summarize the socio-demographic and clinical characteristics of study participants. Kruskal Wallis tests were used to compare the difference between parametric and non-parametric continuous variables, respectively. The area under the receiver operating characteristic curve (AUC) was used to evaluate the value of PT and APTT in the risk stratification and disease prognosis of COVID-19 patients. Ordinal logistic regression was used to identify the factors associated with disease severity and prognosis. A P-value &lt; 0.05 was defined as statistically significant for all results.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Result<\/jats:title>\n<jats:p>Baseline PT at a cut-off value \u2265 16.25 seconds differentiated severe COVID-19 patients from mild and moderate patients (AUC: 0.89, 95% CI: 0.83\u20130.95). PT also differentiated mild COVID-19 patients from moderate and severe patients at a cut-off value \u2264 15.35 seconds (AUC: 0.90, 95% CI: 0.84\u20130.96). Moreover, alcohol drinkers were a 3.52 times more likely chance of having severe disease than non-drinkers (95% CI: 1.41\u20138.81). A one-year increment in age also increased the odds of disease severity by 6% (95% CI: 3\u20139%). An increment of \u2265 0.65 seconds from the baseline PT predicted poor prognosis (AUC: 0.93, 0.87\u20130.99).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions and recommendations<\/jats:title>\n<jats:p>Prolonged baseline PT was observed in severe COVID-19 patients. Prolonged baseline PT was also predicted to worsen prognosis. An increase from the baseline PT was associated with worsen prognosis. Therefore, PT can be used as a risk stratification and prognostic marker in COVID-19 patients.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0272216","type":"journal-article","created":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T17:41:41Z","timestamp":1660239701000},"page":"e0272216","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["Risk stratification and prognostic value of prothrombin time and activated partial thromboplastin time among COVID-19 patients"],"prefix":"10.1371","volume":"17","author":[{"given":"Esayas","family":"Tekle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5347-1138","authenticated-orcid":true,"given":"Yemataw","family":"Gelaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mulat","family":"Dagnew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aschalew","family":"Gelaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markos","family":"Negash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyuel","family":"Kassa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0892-4964","authenticated-orcid":true,"given":"Segenet","family":"Bizuneh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dessalew","family":"Wudineh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fikir","family":"Asrie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2022,8,11]]},"reference":[{"issue":"9","key":"pone.0272216.ref001","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1097\/CM9.0000000000000819","article-title":"Diagnosis and treatment protocol for novel coronavirus pneumonia (trial version 7).","volume":"133","author":"P.-F. 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Karadag","year":"2011","journal-title":"Optimal sample size determination for ANOVA designs"},{"key":"pone.0272216.ref029","article-title":"f.D. and Prevention, Alcohol use and your health","author":"C. Control","journal-title":"Fact sheet."},{"issue":"11","key":"pone.0272216.ref030","doi-asserted-by":"crossref","first-page":"e0260368","DOI":"10.1371\/journal.pone.0260368","article-title":"Anthropometric failures and its associated factors among preschool-aged children in a rural community in southwest Ethiopia","volume":"16","author":"K. Bidira","year":"2021","journal-title":"Plos one"},{"issue":"18","key":"pone.0272216.ref031","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1056\/NEJMoa2002032","article-title":"Clinical characteristics of coronavirus disease 2019 in China.","volume":"382","author":"W.-J. Guan","year":"2020","journal-title":"New England journal of medicine"},{"issue":"9","key":"pone.0272216.ref032","doi-asserted-by":"crossref","first-page":"999","DOI":"10.26719\/emhj.20.105","article-title":"Blood coagulation parameters in patients with severe COVID-19 from Kermanshah Province, Islamic Republic of Iran","volume":"26","author":"B. Sayad","year":"2020","journal-title":"rn Mediterranean Health Journal"},{"key":"pone.0272216.ref033","author":"S.K. Singh","year":"2016"},{"issue":"1","key":"pone.0272216.ref034","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2180-14-134","article-title":"Activation of coagulation and tissue fibrin deposition in experimental influenza in ferrets","volume":"14","author":"M. Goeijenbier","year":"2014","journal-title":"BMC microbiology"},{"issue":"10","key":"pone.0272216.ref035","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1002\/jmv.23354","article-title":"Viral infections and mechanisms of thrombosis and bleeding","volume":"84","author":"M. Goeijenbier","year":"2012","journal-title":"Journal of medical virology"},{"issue":"5","key":"pone.0272216.ref036","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.jhep.2020.06.006","article-title":"COVID-19 and the liver","volume":"73","author":"D. Jothimani","year":"2020","journal-title":"Journal of Hepatology"},{"key":"pone.0272216.ref037","doi-asserted-by":"crossref","first-page":"100273","DOI":"10.1016\/j.aohep.2020.10.001","article-title":"Liver disease and outcomes among COVID-19 hospitalized patients\u2013a systematic review and meta-analysis","volume":"21","author":"A. Sharma","year":"2021","journal-title":"Annals of hepatology"},{"issue":"1","key":"pone.0272216.ref038","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s12985-021-01593-1","article-title":"Liver injury in COVID-19: clinical features and treatment management","volume":"18","author":"D. Yu","year":"2021","journal-title":"Virology Journal"},{"issue":"1","key":"pone.0272216.ref039","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12939-018-0816-y","article-title":"Prevalence and associated factors of underweight among children 6\u201359 months of age in Takusa district, Northwest Ethiopia.","volume":"17","author":"G. Nigatu","year":"2018","journal-title":"International journal for equity in health"},{"issue":"6","key":"pone.0272216.ref040","doi-asserted-by":"crossref","first-page":"e0252939","DOI":"10.1371\/journal.pone.0252939","article-title":"Blood coagulation parameter abnormalities in hospitalized patients with confirmed COVID-19 in Ethiopia","volume":"16","author":"S. Araya","year":"2021","journal-title":"Plos one"},{"issue":"19","key":"pone.0272216.ref041","doi-asserted-by":"crossref","first-page":"4370","DOI":"10.12998\/wjcc.v8.i19.4370","article-title":"Prolonged prothrombin time at admission predicts poor clinical outcome in COVID-19 patients","volume":"8","author":"L. Wang","year":"2020","journal-title":"World J Clin Cases"},{"key":"pone.0272216.ref042","article-title":"Prothrombin time.","author":"R. Yang","journal-title":"StatPearls Publishing"},{"issue":"1","key":"pone.0272216.ref043","doi-asserted-by":"crossref","first-page":"42","DOI":"10.4997\/JRCPE.2014.110","article-title":"Coagulation.","volume":"44","author":"Y. Chee","year":"2014","journal-title":"The journal of the Royal College of Physicians of Edinburgh"},{"issue":"1","key":"pone.0272216.ref044","first-page":"1","article-title":"SARS-CoV-2 induced thrombocytopenia as an important biomarker significantly correlated with abnormal coagulation function, increased intravascular blood clot risk and mortality in COVID-19 patients.","volume":"9","author":"C. Bao","year":"2020","journal-title":"Experimental Hematology & Oncology"},{"issue":"9","key":"pone.0272216.ref045","doi-asserted-by":"crossref","first-page":"e671","DOI":"10.1016\/S2352-3026(20)30217-9","article-title":"Haematological characteristics and risk factors in the classification and prognosis evaluation of COVID-19: a retrospective cohort study","volume":"7","author":"D. Liao","year":"2020","journal-title":"The Lancet Haematology"},{"issue":"10","key":"pone.0272216.ref046","doi-asserted-by":"crossref","first-page":"e0241329","DOI":"10.1371\/journal.pone.0241329","article-title":"The values of coagulation function in COVID-19 patients","volume":"15","author":"X. Jin","year":"2020","journal-title":"PLoS One"},{"issue":"11","key":"pone.0272216.ref047","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9113482","article-title":"Coagulation Parameters: An Efficient Measure for Predicting the Prognosis and Clinical Management of Patients with COVID-19","volume":"9","author":"M. Quintana-D\u00edaz","year":"2020","journal-title":"J Clin Med"},{"issue":"7","key":"pone.0272216.ref048","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1515\/cclm-2020-0188","article-title":"Prominent changes in blood coagulation of patients with SARS-CoV-2 infection","volume":"58","author":"H. Han","year":"2020","journal-title":"Clinical Chemistry and Laboratory Medicine (CCLM)"},{"issue":"6","key":"pone.0272216.ref049","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1111\/bjh.16749","article-title":"COVID19 coagulopathy in Caucasian patients","volume":"189","author":"H. Fogarty","year":"2020","journal-title":"British Journal of Haematology"},{"key":"pone.0272216.ref050","first-page":"1076029620943671","article-title":"Coagulation Status and Venous Thromboembolism Risk in African Americans: A Potential Risk Factor in COVID-19","author":"G.H. 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