{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T17:32:19Z","timestamp":1767979939391,"version":"3.49.0"},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Feasible estimations of perioperative changes in oxygen consumption (VO<jats:sub>2<\/jats:sub>) could enable larger studies of its role in postoperative outcomes. Current methods, either by reverse Fick calculations using pulmonary artery catheterisation or metabolic by breathing gas analysis, are often deemed too invasive or technically requiring. In addition, reverse Fick calculations report generally lower values of oxygen consumption.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>We investigated the relationship between perioperative estimations of VO<jats:sub>2<\/jats:sub> (EVO<jats:sub>2<\/jats:sub>), from LiDCO<jats:sup>\u2122<\/jats:sup>plus-derived (LiDCO Ltd, Cambridge, UK) cardiac output and arterial-central venous oxygen content difference (Ca-cvO<jats:sub>2<\/jats:sub>), with indirect calorimetry (GVO<jats:sub>2<\/jats:sub>) by QuarkRMR (COSMED srl. Italy), using data collected 2017\u20132018 during a prospective observational study on perioperative oxygen transport in 20 patients &gt;65 years during epidural and general anaesthesia for open pancreatic or liver resection surgery. Eighty-five simultaneous intra- and postoperative measurements at different perioperative stages were analysed for prediction, parallelity and by traditional agreement assessment.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Unadjusted bias between GVO<jats:sub>2<\/jats:sub> and EVO<jats:sub>2<\/jats:sub> indexed for body surface area was 26 (95% CI 20 to 32) with limits of agreement (1.96SD) of -32 to 85 ml min<jats:sup>\u22121<\/jats:sup>m<jats:sup>\u22122<\/jats:sup>. Correlation adjusted for the bias was moderate, intraclass coefficient(A,1) 0.51(95% CI 0.34 to 0.65) [F (84,84) = 3.07, <jats:italic>P<\/jats:italic>&lt;0.001]. There was an overall association between GVO<jats:sub>2<\/jats:sub> and EVO<jats:sub>2<\/jats:sub>, in a random coefficient model [GVO<jats:sub>2<\/jats:sub> = 73(95% CI 62 to 83) + 0.45(95% CI 0.29 to 0.61) EVO<jats:sub>2<\/jats:sub> ml min<jats:sup>\u22121<\/jats:sup>m<jats:sup>\u22122<\/jats:sup>, <jats:italic>P<\/jats:italic>&lt;0.0001]. GVO<jats:sub>2<\/jats:sub> and EVO<jats:sub>2<\/jats:sub> changed in parallel intra- and postoperatively when normalised to their respective overall means.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Based on this data, estimations from LiDCO<jats:sup>\u2122<\/jats:sup>plus-derived cardiac output and Ca-cvO<jats:sub>2<\/jats:sub> are not reliable as a surrogate for perioperative VO<jats:sub>2<\/jats:sub>. Results were in line with previous studies comparing Fick-based and metabolic measurements but limited by variability of data and possible underpowering. The parallelity at different perioperative stages and the prediction model can provide useful guidance and methodological tools for future studies on similar methods in larger samples.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0272239","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T17:32:04Z","timestamp":1721928724000},"page":"e0272239","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Perioperative estimations of oxygen consumption from LiDCO\u2122plus-derived cardiac output and Ca-cvO2 difference: Relationship with measurements by indirect calorimetry in elderly patients undergoing major abdominal surgery"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5956-9942","authenticated-orcid":true,"given":"Julia","family":"Jakobsson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl","family":"Nor\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Hagel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus","family":"Backheden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigridur","family":"Kalman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erzs\u00e9bet","family":"Bartha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,7,25]]},"reference":[{"issue":"7","key":"pone.0272239.ref001","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1097\/00003246-199307000-00010","article-title":"Hemodynamic and oxygen transport responses in survivors and nonsurvivors of high-risk surgery","volume":"21","author":"WC Shoemaker","year":"1993","journal-title":"Crit Care Med"},{"key":"pone.0272239.ref002","first-page":"CD004082","article-title":"Perioperative increase in global blood flow to explicit defined goals and outcomes following surgery","volume":"11","author":"MP Grocott","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"pone.0272239.ref003","article-title":"Principles for minimizing oxygen debt: can they translate to clinical application and improve outcomes?","author":"K Maheshwari","year":"2020","journal-title":"Best Practice & Research Clinical Anaesthesiology"},{"issue":"2","key":"pone.0272239.ref004","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/aas.13265","article-title":"The effects of general anaesthesia on oxygen consumption: A meta-analysis guiding future studies on perioperative oxygen transport","volume":"63","author":"J Jakobsson","year":"2019","journal-title":"Acta Anaesthesiol Scand"},{"issue":"1","key":"pone.0272239.ref005","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s12871-020-01011-z","article-title":"Estimated oxygen extraction versus dynamic parameters of fluid-responsiveness for perioperative hemodynamic optimization of patients undergoing non-cardiac surgery: a non-inferiority randomized controlled trial","volume":"20","author":"A Carsetti","year":"2020","journal-title":"BMC anesthesiol"},{"issue":"1","key":"pone.0272239.ref006","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1213\/ANE.0000000000006343","article-title":"Energy Expenditure Under General Anesthesia: An Observational Study Using Indirect Calorimetry in Patients Having Noncardiac Surgery","volume":"137","author":"L Briesenick","year":"2023","journal-title":"Anesth Analg"},{"issue":"2","key":"pone.0272239.ref007","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1023\/A:1007413018732","article-title":"A formula to calculate oxygen uptake during low flow anesthesia based on FIO2 measurement","volume":"14","author":"P Biro","year":"1998","journal-title":"J Clin Monit Comput"},{"issue":"7","key":"pone.0272239.ref008","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1046\/j.1365-2044.2002.02606.x","article-title":"Measurement of systemic oxygen uptake during low-flow anaesthesia with a standard technique vs. a novel method","volume":"57","author":"IE Leonard","year":"2002","journal-title":"Anaesthesia"},{"issue":"4","key":"pone.0272239.ref009","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/bjaceaccp\/mkh033","article-title":"Oxygen delivery and haemoglobin","volume":"4","author":"S McLellan","year":"2004","journal-title":"Cont Ed Anaesth Crit Care Pain"},{"issue":"7","key":"pone.0272239.ref010","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/j.1399-6576.1997.tb04792.x","article-title":"Calculated versus measured oxygen consumption during and after cardiac surgery. 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