{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:47:10Z","timestamp":1789750030724,"version":"4.0.1"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Danone Dumex (M) Sdn Bhd","award":["6368500"],"award-info":[{"award-number":["6368500"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>This study examined the association between height and the risk of Gestational Diabetes Mellitus (GDM), and whether this association was mediated or moderated by early pregnancy body mass index (BMI) and gestational weight gain (GWG) that are known independent risk factors for GDM. Data of a retrospective cohort of pregnant women (N = 1,945) were extracted from antenatal clinic cards. The cut-off values of height in relation to risk of GDM were identified using receiver operating characteristic analysis and four categories of height were derived: &lt; 150 cm, 150\u2013155 cm, 156\u2013160 cm, and &gt; 160cm. Mediation analysis was performed using the Preacher and Hayes bootstrapping method while the moderation effect was tested with multiple regression analysis with interaction terms. Although there was no mediation effect of BMI and GWG on the association between height and risk of GDM, both factors moderated this association with a significant association between shorter height and risk of GDM was observed in overweight \/ obese women (height &lt; 150 cm: AOR = 1.41, 95% CI = 1.03\u20132.44; height 156\u2013160 cm: AOR = 1.48, 95% CI = 1.03\u20132.14). Overweight \/ obese women with height &lt; 150 cm and excessive GWG at the end of the second trimester (AOR = 2.25, 95% CI = 1.45\u20134.17) had significantly higher risk of GDM than those without these factors. Short stature (&lt; 150 cm) was significantly associated with GDM risk among OW\/OB women with excessive gestational weight gain at the end of second trimester. This finding underscores the importance of maintaining a healthy BMI during reproductive age and gaining weight in recommended range during pregnancy.<\/jats:p>","DOI":"10.1371\/journal.pone.0272253","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T18:54:42Z","timestamp":1659380082000},"page":"e0272253","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Early pregnancy body mass index and gestational weight gain: A mediating or moderating factor for short stature and risk of gestational diabetes mellitus?"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0454-641X","authenticated-orcid":true,"given":"Heng Yaw","family":"Yong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5347-4627","authenticated-orcid":true,"given":"Zalilah","family":"Mohd Shariff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barakatun Nisak","family":"Mohd Yusof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zulida","family":"Rejali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne Yee Siang","family":"Tee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Bindels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eline M.","family":"van der Beek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,8,1]]},"reference":[{"key":"pone.0272253.ref001","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/BF00403292","article-title":"Height and glucose 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Bo","year":"2001","journal-title":"Diabetologia"},{"key":"pone.0272253.ref018","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/dme.12355","article-title":"Height and the risk of gestational diabetes: Variations by race\/ethnicity","volume":"31","author":"J Brite","year":"2014","journal-title":"Diabet Med"},{"key":"pone.0272253.ref019","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1093\/ajcn\/74.3.287","article-title":"Family social class, maternal body mass index, childhood body mass index, and age at menarche as predictors of adult obesity","volume":"74","author":"J Laitinen","year":"2001","journal-title":"Am J Clin Nutr"},{"key":"pone.0272253.ref020","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/nutrit\/nuv105","article-title":"Adult height, nutrition, and population health.","volume":"74","author":"JM Perkins","year":"2016","journal-title":"Nutr Rev."},{"key":"pone.0272253.ref021","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1017\/S0021932003002633","article-title":"Determinants of variation in adult body height","volume":"35","author":"K. Silventoinen","year":"2003","journal-title":"J Biosoc Sci"},{"key":"pone.0272253.ref022","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1365-3016.2007.00899.x","article-title":"Diet during early pregnancy and development of gestational diabetes","volume":"22","author":"JS Radesky","year":"2008","journal-title":"Paediatr Perinat Epidemiol"},{"key":"pone.0272253.ref023","doi-asserted-by":"crossref","unstructured":"IDF. IDF Diabetes Atlas 8th edition. idf.org. 2017. doi: 10.1289\/image.ehp.v119.i03","DOI":"10.1289\/image.ehp.v119.i03"},{"key":"pone.0272253.ref024","volume-title":"National Health and Morbidity Survery 2016: Maternal and Child Health (MCH) Volume Two: Maternal and Child Health Findings","author":"National Health and Morbidity Survey","year":"2016"},{"key":"pone.0272253.ref025","first-page":"S94","article-title":"Prevalence of gestational diabetes mellitus (GDM) in pregnant women aged 30 to 34 years old at Phramongkutklao Hospital.","volume":"89","author":"P Sumeksri","year":"2006","journal-title":"J Med Assoc Thai"},{"key":"pone.0272253.ref026","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4093\/dmj.2011.35.1.1","article-title":"Gestational diabetes in Korea: incidence and risk factors of diabetes in women with previous gestational diabetes","volume":"35","author":"HC Jang","year":"2011","journal-title":"Diabetes Metab J"},{"key":"pone.0272253.ref027","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0140-6736(14)61682-2","article-title":"Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990\u20132013: A systematic analysis for the Global Burden of Disease Study 2013","volume":"385","author":"M Naghavi","year":"2015","journal-title":"Lancet"},{"key":"pone.0272253.ref028","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1530\/EJE-18-0003","article-title":"Risk factors for hyperglycemia in pregnancy in the DALI study differ by period of pregnancy and OGTT time point","volume":"179","author":"LC Mendoza","year":"2018","journal-title":"Eur J Endocrinol"},{"key":"pone.0272253.ref029","doi-asserted-by":"crossref","first-page":"e13410","DOI":"10.7554\/eLife.13410","article-title":"A century of trends in adult human height.","volume":"5","author":"J Bentham","year":"2016","journal-title":"Elife"},{"key":"pone.0272253.ref030","first-page":"207","article-title":"Independent and combined effects of age, body mass index and gestational weight gain on the risk of gestational diabetes mellitus","volume":"10","author":"HY Yong","year":"2020","journal-title":"Sci Rep"},{"key":"pone.0272253.ref031","volume-title":"Perinatal Care Manual:","author":"Ministry of Health Malaysia","year":"2013","edition":"3"},{"key":"pone.0272253.ref032","volume-title":"Physical status: The Use and Interpretation of Anthropometry. Report of a WHO Expert Committee.","author":"WHO","year":"1995"},{"key":"pone.0272253.ref033","volume-title":"Introduction to Mediation, Moderation, and Conditional Process Analysis Third Edition A Regression-Based Approach","author":"A. Hayes","year":"2022","edition":"3"},{"key":"pone.0272253.ref034","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1111\/1471-0528.15661","article-title":"Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, North American and Australian cohorts.","volume":"126","author":"S Santos","year":"2019","journal-title":"BJOG An Int J Obstet Gynaecol"},{"key":"pone.0272253.ref035","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1186\/s12884-020-03071-y","article-title":"Effects of pre-pregnancy body mass index and gestational weight gain on maternal and infant complications.","volume":"20","author":"Y Sun","year":"2020","journal-title":"BMC Pregnancy Childbirth"},{"key":"pone.0272253.ref036","doi-asserted-by":"crossref","first-page":"e82310","DOI":"10.1371\/journal.pone.0082310","article-title":"Maternal prepregnancy body mass index and gestational weight gain on pregnancy outcomes.","volume":"8","author":"N Li","year":"2013","journal-title":"PLoS One"},{"key":"pone.0272253.ref037","doi-asserted-by":"crossref","first-page":"3735","DOI":"10.3390\/ijerph16193735","article-title":"Pre-Pregnancy BMI Influences the Association of Dietary Quality and Gestational Weight Gain","volume":"16","author":"HY Yong","year":"2019","journal-title":"The SECOST Study. 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