{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T18:11:34Z","timestamp":1789323094979,"version":"build-2803163510"},"reference-count":74,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T00:00:00Z","timestamp":1664323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Background<\/jats:title><jats:p>The COVID-19 pandemic has led to the death of many people worldwide. The World Health Organization (WHO) has declared vaccine resistance as one of the greatest health threats in the world even before the COVID-19 epidemic. The aim of this study was to evaluate the acceptance of COVID-19 vaccine in pregnant women.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Method<\/jats:title><jats:p>We performed this systematic review and meta-analysis in accordance with the PRISMA guidelines. We applied the standard search strategy to the PubMed\/Medline, Web of Science (ISI), Scopus, Science Direct, Cochrane Library, EMBASE, and EBSCO databases, and the Google Scholar search engine. Heterogeneity between studies was relatively high and therefore meta-analyses were performed based on random effects model with 95% CI using STATA version 16.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Results<\/jats:title><jats:p>In 16 articles with a sample size of 19219 pregnant women, the acceptance of COVID-19 vaccine was estimated 53.46% (95%CI: 47.64%-59.24%). Subgroup analysis was performed based on continent (p = 0.796), data collection method (p = 0.450) and meta-regression based on the month of the study (P&lt;0.001), and only meta-regression was significant based on the month of the study. The effect of some variables such as graviad (OR = 1.02 [95%CI: 0.90\u20131.16]), maternal age was (OR = 1.02 [95%CI: 0.93\u20131.11]) and history of influenza vaccination (OR = 0.87 [95%CI: 0.71\u20131.06]) on COVID-19 vaccine acceptance was evaluated, which was not significant.<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of COVID-19 vaccine acceptance in pregnant women was 53.46%, which was much lower than the general COVID-19 vaccination. Therefore, necessary interventions should be taken to increase the acceptance of the vaccine, address safety concerns and educate about it.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0272273","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T17:57:49Z","timestamp":1664387869000},"page":"e0272273","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":43,"title":["COVID-19 vaccine acceptance among pregnant women worldwide: A systematic review and meta-analysis"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4509-5520","authenticated-orcid":true,"given":"Milad","family":"Azami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzieh Parizad","family":"Nasirkandy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi","family":"Esmaeili Gouvarchin Ghaleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4775-008X","authenticated-orcid":true,"given":"Reza","family":"Ranjbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,9,28]]},"reference":[{"key":"pone.0272273.ref001","first-page":"1","article-title":"\u201cThis choice does not just affect me.\u201d Attitudes of pregnant women toward COVID-19 vaccines: a mixed-methods study","author":"S Geoghegan","year":"2021","journal-title":"Human Vaccines & Immunotherapeutics"},{"issue":"11","key":"pone.0272273.ref002","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/S1473-3099(20)30797-0","article-title":"The intersection of COVID-19 and mental health","volume":"20","author":"TLI Diseases","year":"2020","journal-title":"The Lancet Infectious Diseases"},{"issue":"1","key":"pone.0272273.ref003","doi-asserted-by":"crossref","first-page":"31","DOI":"10.5114\/pjr.2021.103379","article-title":"Chest computed tomography scan findings of coronavirus disease 2019 (COVID-19) patients: a comprehensive systematic review and meta-analysis","volume":"86","author":"M Karimian","year":"2021","journal-title":"Polish Journal of Radiology"},{"issue":"1","key":"pone.0272273.ref004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12978-021-01070-6","article-title":"The impact of the COVID-19 pandemic on maternal and perinatal health: a scoping review","volume":"18","author":"B Kotlar","year":"2021","journal-title":"Reproductive Health"},{"key":"pone.0272273.ref005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.21613\/GORM.2021.1170","article-title":"COVID-19 positive woman presented with preterm labor: case report","author":"IA Abdelazim","year":"2021","journal-title":"Gynecology Obstetrics & Reproductive Medicine"},{"key":"pone.0272273.ref006","volume":"2021","author":"Organization WH","year":"2021","journal-title":"COVID-19 weekly epidemiological update, 19"},{"issue":"2","key":"pone.0272273.ref007","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1097\/AOG.0000000000004025","article-title":"Characteristics and outcomes of 241 births to women with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection at five New York City medical centers","volume":"136","author":"R Khoury","year":"2020","journal-title":"Obstetrics & Gynecology"},{"issue":"1","key":"pone.0272273.ref008","first-page":"1","article-title":"Pregnant women\u2019s well-being and worry during the COVID-19 pandemic: a cross-sectional study","volume":"21","author":"F Mortazavi","year":"2021","journal-title":"BMC pregnancy and childbirth"},{"key":"pone.0272273.ref009","article-title":"Pfizer and BioNTech Announce Vaccine Candidate agains t COVID-19 Achieved Success in First Interim Analysis from Phase 3 Study","author":"B Pfizer","year":"2020","journal-title":"Pfizer New York"},{"key":"pone.0272273.ref010","article-title":"Moderna announces primary efficacy analysis in phase 3 COVE study for its COVID-19 vaccine candidate and filing today with US FDA for emergency use authorization","author":"I. 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