{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:49:25Z","timestamp":1762325365385,"version":"3.40.5"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"\nBackground<\/jats:title>\nContinuous comprehensive treatment is still needed after endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS) to promote the recovery of sinus mucosal morphology and function. Traditional Chinese medicine (TCM) nasal irrigation is a promising external treatment of TCM, but at present, the application of TCM nasal irrigation after ESS for CRS has not been recommended by the guidelines. Therefore, this article aims to develop a systematic overview and meta-analysis protocol to assess the effectiveness and safety of Chinese herbal nasal rinse for CRS recovery after ESS.<\/jats:p>\n<\/jats:sec>\n\nMethods<\/jats:title>\nSeven databases shall be retrieved from their inception until December 2021. Eligible randomized controlled trials will be covered in the study. The outcome indicators of the survey will consist of efficacy, visual analogue scale score, Lund-Kennedy score for nasal endoscopy, Lund-Mackay score for sinus computed tomography and other secondary outcome indicators. The selection of literature, extraction of data, and methodological quality evaluation of literature shall be conducted by two researchers separately. If there is any dispute, it can be discussed and solved by a third researcher. Review Manager 5.3 software will be applied to data analysis.<\/jats:p>\n<\/jats:sec>\n\nResults<\/jats:title>\nThe article will make a detailed research programme to explore the efficacy and safety of TCM nasal irrigation on CRS recovery after ESS.<\/jats:p>\n<\/jats:sec>\n\nConclusion<\/jats:title>\nThis protocol is suitable for evaluating the effectiveness and safety of TCM nasal rinse for CRS recovery after ESS, and can provide corresponding evidence-based medical evidence.<\/jats:p>\n<\/jats:sec>\n\nSystematic review registration<\/jats:title>\nOpen Science Framework Registration DOI: 10.17605\/OSF.IO\/ZV73Q<\/jats:ext-link>.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0272371","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T18:49:40Z","timestamp":1659379780000},"page":"e0272371","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy and safety of traditional Chinese medicine nasal irrigation on chronic rhinosinusitis recovery after endoscopic sinus surgery: A protocol for a systematic review and meta-analysis"],"prefix":"10.1371","volume":"17","author":[{"given":"Yepeng","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaning","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0743-6037","authenticated-orcid":true,"given":"Qinxiu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2022,8,1]]},"reference":[{"issue":"Suppl S29","key":"pone.0272371.ref001","first-page":"1","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps 2020","volume":"58","author":"WJ Fokkens","year":"2020","journal-title":"Rhinology"},{"issue":"5","key":"pone.0272371.ref002","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/all.12577","article-title":"Epidemiology of chronic rhinosinusitis: results from a cross-sectional survey in seven Chinese cities","volume":"70","author":"JB Shi","year":"2015","journal-title":"Allergy"},{"issue":"2","key":"pone.0272371.ref003","doi-asserted-by":"crossref","first-page":"176","DOI":"10.4168\/aair.2020.12.2.176","article-title":"Chinese Society of Allergy and Chinese Society of Otorhinolaryngology-Head and Neck Surgery Guideline for Chronic Rhinosinusitis.","volume":"12","author":"Z Liu","year":"2020","journal-title":"Allergy Asthma Immun"},{"issue":"9","key":"pone.0272371.ref004","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1111\/j.1398-9995.2011.02646.x","article-title":"Chronic rhinosinusitis in European underestimated disease. 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