{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T10:06:24Z","timestamp":1793095584153,"version":"4.5.0"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T00:00:00Z","timestamp":1660262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Objectives<\/jats:title><jats:p>To evaluate long-term outcome using the BioMedtrix\u2122 TPLO Curve<jats:sup>\u00ae<\/jats:sup>plate in dogs with cranial cruciate ligament disease (CrCLd) treated by tibial plateau leveling osteotomy (TPLO).<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Study design<\/jats:title><jats:p>Retrospective case study.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Animals<\/jats:title><jats:p>Dogs (n = 323, 337 stifles).<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Methods<\/jats:title><jats:p>Medical records were searched for dogs presented with CrCLd and treated by TPLO with the BioMedtrix\u2122 TPLO Curve<jats:sup>\u00ae<\/jats:sup>plate for 3.5 mm screws between March 2018 and December 2020. Tibial plateau angles (TPA) were measured on preoperative, postoperative, and follow-up radiographs. Changes in TPA between postoperative and follow-up radiographs (ModTPA) were calculated. Radiographic bone healing was scored. Complications were evaluated. Surgical site infections (SSI) were compared to a control group of dogs treated with the Synthes\u2122 TPLO plate between January and December 2017. Owners of both groups were contacted by telephone at least 1 year postoperatively.<\/jats:p><\/jats:sec><jats:sec id=\"sec005\"><jats:title>Results<\/jats:title><jats:p>The BioMedtrix\u2122 group was composed of 237 dogs (248 stifles), the control group was composed of 86 dogs (89 stifles). In the BioMedtrix\u2122 group, radiographic follow-up was performed at a median of 48 days. Average ModTPA was 1.2\u00b0. Bone healing was graded as complete, good, poor, and none in 18%, 62%, 20%, and 0%, respectively. At a median of 786 days postoperatively, minor and major postoperative complications were observed in 6 (2.4%) and 32 (12.9%) cases in this group, respectively. During the first year following the surgery, 23 (9.3%) and 12 (13.5%) cases suffered a SSI, of which 12 (4.8%) and 7 (7.9%) had their implant explanted in the BioMedtrix\u2122 group and the control group, respectively. There was no significant difference between groups for SSI and implant explantations (p = 0.31 and p = 0.29, respectively).<\/jats:p><\/jats:sec><jats:sec id=\"sec006\"><jats:title>Conclusion<\/jats:title><jats:p>The BioMedtrix\u2122 TPLO Curve<jats:sup>\u00ae<\/jats:sup>plate provided a reliable fixation system for osteotomy healing after TPLO. Bone healing and long-term complication rates were similar to previous studies using other implants. SSI rates were similar between the BioMedtrix\u2122 group and the control group. The antimicrobial HyProtect<jats:sup>\u00ae<\/jats:sup>coating of the plate did not reduce SSI in this study.<\/jats:p><\/jats:sec><jats:sec id=\"sec007\"><jats:title>Clinical significance<\/jats:title><jats:p>The BioMedtrix\u2122 TPLO Curve<jats:sup>\u00ae<\/jats:sup>plate can be safely used for TPLO. The value of the antimicrobial HyProtect<jats:sup>\u00ae<\/jats:sup>coating of the plate may be questioned, as SSI rate was not lower in this study compared to the control group or previous reports.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0272555","type":"journal-article","created":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T17:42:38Z","timestamp":1660326158000},"page":"e0272555","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Long-term outcome of tibial plateau leveling osteotomy using an antimicrobial silver-based coated plate in dogs"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0868-4991","authenticated-orcid":true,"given":"Geoffrey","family":"Pag\u00e8s","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meike","family":"Hammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Guillaume","family":"Grand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iban","family":"Irubetagoyena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,8,12]]},"reference":[{"key":"pone.0272555.ref001","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.2460\/javma.232.12.1818","article-title":"Prevalence of and risk factors for hip dysplasia and cranial cruciate ligament deficiency in dogs","volume":"232","author":"TH Witsberger","year":"2008","journal-title":"J Am Vet Med Assoc"},{"key":"pone.0272555.ref002","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/9781119261728","volume-title":"Advances in the Canine Cranial Cruciate Ligament","author":"P Muir","year":"2017","edition":"2"},{"key":"pone.0272555.ref003","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0195-5616(93)50082-7","article-title":"Tibial plateau leveling osteotomy for repair of cranial cruciate ligament rupture in the canine.","volume":"23","author":"B Slocum","year":"1993","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"pone.0272555.ref004","doi-asserted-by":"crossref","first-page":"586","DOI":"10.2460\/javma.253.5.586","article-title":"Results of a survey of Veterinary Orthopedic Society members on the preferred method for treating cranial cruciate ligament rupture in dogs weighing more than 15 kilograms (33 pounds).","volume":"253","author":"DJ Von Pfeil","year":"2018","journal-title":"J Am Vet Med Assoc"},{"key":"pone.0272555.ref005","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1532-950X.2008.00389.x","article-title":"Comparison of locking and conventional screws for maintenance of tibial plateau positioning and biomechanical stability after locking tibial plateau leveling osteotomy plate fixation","volume":"37","author":"M Leitner","year":"2008","journal-title":"Vet Surg"},{"key":"pone.0272555.ref006","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1532-950X.2008.00464.x","article-title":"Biomechanical comparison of two alternative tibial plateau leveling osteotomy plates with the original standard in an axially loaded gap model: an in vitro study","volume":"38","author":"PA Kloc","year":"2009","journal-title":"Vet Surg"},{"key":"pone.0272555.ref007","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1532-950X.2010.00656.x","article-title":"Comparison of tibial plateau angle changes after tibial plateau leveling osteotomy fixation with conventional or locking screw technology","volume":"39","author":"AL Conkling","year":"2010","journal-title":"Vet Surg"},{"key":"pone.0272555.ref008","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1111\/j.1532-950X.2012.01053.x","article-title":"Comparison of TPA, Bone Healing, and Intra-articular Screw Placement using Conventional Nonlocked Application of Surgeon-Contoured versus Locked Application of Precontoured TPLO Plates in Dogs","volume":"41","author":"U Krotscheck","year":"2012","journal-title":"Vet Surg"},{"key":"pone.0272555.ref009","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1111\/j.1532-950X.2013.12048.x","article-title":"Radiographic Outcome and Complications of Tibial Plateau Leveling Osteotomy Stabilized With an Anatomically Contoured Locking Bone Plate.","volume":"42","author":"MP Kowaleski","year":"2013","journal-title":"Vet Surg"},{"key":"pone.0272555.ref010","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/j.1532-950X.2010.00663.x","article-title":"Predictive variables for complications after TPLO with stifle inspection by arthrotomy in 1000 consecutive dogs.","volume":"39","author":"N Fitzpatrick","year":"2010","journal-title":"Vet Surg"},{"key":"pone.0272555.ref011","first-page":"249","article-title":"Complications associated with tibial plateau leveling osteotomy: A retrospective of 1519 procedures","volume":"55","author":"TJ Coletti","year":"2014","journal-title":"Can Vet J"},{"key":"pone.0272555.ref012","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1111\/j.1532-950X.2013.12033.x","article-title":"Comparison of Complication Rates and Clinical Outcome Between Tibial Plateau Leveling Osteotomy and a Modified Cranial Closing Wedge Osteotomy for Treatment of Cranial Cruciate Ligament Disease in Dogs","volume":"42","author":"B Oxley","year":"2013","journal-title":"Vet Surg"},{"key":"pone.0272555.ref013","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/vsu.12796","article-title":"Protocol changes to reduce implant-associated infection rate after tibial plateau leveling osteotomy: 703 dogs, 811 TPLO (2006\u20132014).","volume":"47","author":"SL Stine","year":"2018","journal-title":"Vet Surg"},{"key":"pone.0272555.ref014","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1055\/s-0038-1676352","article-title":"Prospective Evaluation of Surgical Wound Dressings and the Incidence of Surgical Site Infections in Dogs Undergoing a Tibial Plateau Levelling Osteotomy.","volume":"32","author":"J Gianetto","year":"2019","journal-title":"Vet Comp Orthop Traumatol"},{"key":"pone.0272555.ref015","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/vsu.12958","article-title":"A prospective, randomized, double-blinded, placebo-controlled clinical study on postoperative antibiotherapy in 150 arthroscopy- assisted tibial plateau leveling osteotomies in dogs","volume":"47","author":"DD Spencer","year":"2018","journal-title":"Vet Surg"},{"key":"pone.0272555.ref016","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/vsu.12736","article-title":"Comparison of iatrogenic articular cartilage injury in canine stifle arthroscopy versus medial parapatellar mini-arthrotomy in a cadaveric model","volume":"47","author":"CP Rogatko","year":"2018","journal-title":"Vet Surg"},{"key":"pone.0272555.ref017","first-page":"366","volume-title":"An atlas of surgical approaches to the bones and joints of the dog and cat (ed 4)","author":"DL Piermattei","year":"2004"},{"key":"pone.0272555.ref018","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1532-950X.2008.00381.x","article-title":"Radiographic measurement of canine tibial angles in the sagittal plane","volume":"37","author":"DI Dismukes","year":"2008","journal-title":"Vet Surg"},{"key":"pone.0272555.ref019","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1111\/j.1532-950X.2010.00763.x","article-title":"Proposed Definitions and Criteria for Reporting Time Frame, Outcome, and Complications For Clinical Orthopedic Studies in Veterinary Medicine","volume":"39","author":"JL Cook","year":"2010","journal-title":"Vet Surg"},{"key":"pone.0272555.ref020","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0196-6553(99)70088-X","article-title":"Guideline for Prevention of Surgical Site Infection, 1999","volume":"27","author":"AJ Mangram","year":"1999","journal-title":"Am J Infect Control"},{"key":"pone.0272555.ref021","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/vsu.12749","article-title":"Control of hemorrhage through the osteotomy gap during tibial plateau leveling osteotomy: 9 cases","volume":"47","author":"L Matres-Lorenzo","year":"2018","journal-title":"Vet Surg"},{"key":"pone.0272555.ref022","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1532-950X.2010.00783.x","article-title":"Prospective Evaluation of Minimally Invasive Plate Osteosynthesis in 36 Nonarticular Tibial Fractures in Dogs and Cats","volume":"40","author":"LP Guiot","year":"2011","journal-title":"Vet Surg"},{"key":"pone.0272555.ref023","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1111\/vsu.12945","article-title":"Fibular osteotomy to facilitate proximal tibial rotation during tibial plateau leveling osteotomy","volume":"47","author":"JS Zuckerman","year":"2018","journal-title":"Vet Surg"},{"key":"pone.0272555.ref024","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/jso.21498","article-title":"Reduction of Periprosthetic Infection With Silver-Coated Megaprostheses in Patients With Bone Sarcoma.","volume":"101","author":"J Hardes","year":"2010","journal-title":"J Surg Onc"},{"issue":"4","key":"pone.0272555.ref025","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1007\/s12010-017-2503-7","article-title":"Inhibitory Effect of Biosynthesized Silver Nanoparticles from Extract of Nitzschia palea Against Curli-Mediated Biofilm of Escherichia coli","volume":"183","author":"RB Shafreen","year":"2017","journal-title":"Appl Biochem Biotechnol"},{"key":"pone.0272555.ref026","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3415\/VCOT-15-08-0134","article-title":"Evaluation of a silver-impregnated coating to inhibit colonization of orthopaedic implants by biofilm forming methicillin-resistant Staphyloccocus pseudintermedius.","volume":"29","author":"M Azab","year":"2016","journal-title":"Vet Comp Orthop Traumatol"},{"key":"pone.0272555.ref027","doi-asserted-by":"crossref","first-page":"8533","DOI":"10.1016\/j.biomaterials.2013.07.089","article-title":"A review of the biomaterials technologies for infection-resistant surfaces.","volume":"34","author":"D Campoccia","year":"2013","journal-title":"Biomaterials"},{"key":"pone.0272555.ref028","doi-asserted-by":"crossref","first-page":"4708","DOI":"10.1021\/cr300288v","article-title":"Nanobio Silver: Its Interactions with Peptides and Bacteria, and Its Uses in Medicine","volume":"113","author":"S Eckhardt","year":"2013","journal-title":"Chem Rev"},{"key":"pone.0272555.ref029","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/vsu.13337","article-title":"Influence of administration of antimicrobial medications after tibial plateau leveling osteotomy on surgical site infections: A retrospective study of 308 dogs","volume":"49","author":"AC Clark","year":"2020","journal-title":"Vet Surg"},{"key":"pone.0272555.ref030","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1111\/vsu.13436","article-title":"Contributing factors to surgical site infection after tibial plateau leveling osteotomy: A follow-up retrospective study","volume":"49","author":"CR Hagen","year":"2020","journal-title":"Vet Surg"},{"key":"pone.0272555.ref031","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/vsu.13603","article-title":"Efficacy of postoperative antibiotic use after tibial plateau leveling osteotomy in dogs: A systematic review","volume":"50","author":"SC Budsberg","year":"2021","journal-title":"Vet Surg"},{"key":"pone.0272555.ref032","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1111\/vsu.13634","article-title":"Timing of and risk factors for deep surgical site infection requiring implant removal following canine tibial plateau leveling osteotomy","volume":"50","author":"RA McDougall","year":"2021","journal-title":"Vet Surg"},{"key":"pone.0272555.ref033","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3415\/VCOT-11-09-0122","article-title":"Complications of tibial plateau levelling osteotomy in dogs.","volume":"25","author":"MS Bergh","year":"2012","journal-title":"Vet Comp Orthop Traumatol"},{"key":"pone.0272555.ref034","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1055\/s-0037-1616583","article-title":"A novel radiographic method to facilitate measurement of the tibial plateau angle in dogs","volume":"20","author":"J Headrick","year":"2007","journal-title":"Vet Comp Orthop Traumatol"},{"key":"pone.0272555.ref035","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1532-950X.2009.00641.x","article-title":"Evaluation of Intra- and Interobserver Variability and Repeatability of Tibial Plateau Angle Measurements with Digital Radiography Using a Novel Digital Radiographic Program","volume":"39","author":"MD Unis","year":"2010","journal-title":"Vet Surg"},{"key":"pone.0272555.ref036","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1111\/j.1532-950X.2011.00857.x","article-title":"Radiographic Quantitative Assessment of Caudal Proximal Tibial Angulation in 100 Dogs with Cranial Cruciate Ligament Rupture","volume":"40","author":"M Glassman","year":"2011","journal-title":"Vet Surg"},{"key":"pone.0272555.ref037","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1532-950X.2006.00147.x","article-title":"The Effect of Tibial Plateau Angle on Ground Reaction Forces 4\u201317 Months After Tibial Plateau Leveling Osteotomy in Labrador Retrievers","volume":"35","author":"DA Robinson","year":"2006","journal-title":"Vet Surg"},{"key":"pone.0272555.ref038","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3415\/VCOT-12-02-0018","article-title":"Comparative anatomy of the proximal tibia in healthy Labrador Retrievers and Yorkshire Terriers","volume":"26","author":"B Vedrine","year":"2013","journal-title":"Vet Comp Orthop Traumatol"},{"key":"pone.0272555.ref039","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1111\/vsu.12915","article-title":"Factors associated with early tibial tuberosity fracture after tibial plateau leveling osteotomy","volume":"47","author":"LR Mehrkens","year":"2018","journal-title":"Vet Surg"},{"key":"pone.0272555.ref040","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1055\/s-0038-1632797","article-title":"Geometric analysis evaluating the effect of tibial plateau leveling osteotomy position on postoperative tibial plateau slope","volume":"17","author":"MP Kowaleski","year":"2004","journal-title":"Vet Comp Orthop Traumatol"},{"key":"pone.0272555.ref041","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/j.1532-950X.2005.00051.x","article-title":"The Effect of Tibial Plateau Leveling Osteotomy Position on Cranial Tibial Subluxation: An In Vitro Study","volume":"34","author":"MP Kowaleski","year":"2005","journal-title":"Vet Surg"},{"key":"pone.0272555.ref042","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/j.1532-950X.2008.00390.x","article-title":"Accuracy of Fragment Positioning after TPLO and Effect on Biomechanical Stability","volume":"37","author":"M Windolf","year":"2008","journal-title":"Vet Surg"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0272555","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,25]],"date-time":"2023-11-25T17:23:39Z","timestamp":1700933019000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0272555"}},"subtitle":[],"editor":[{"given":"Ashraf M.","family":"Abu-Seida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,8,12]]},"references-count":42,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2022,8,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0272555","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,12]]}}}