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Although central nervous system processing has emerged as a contributor to injury risk, brain activity associated with the resultant ACL injury-risk biomechanics is limited. Thus, the purposes of this preliminary study were to determine the relationship between bilateral motor control brain activity and injury risk biomechanics and isolate differences in brain activity for those who demonstrate high versus low ACL injury risk. Thirty-one high school female athletes completed a novel, multi-joint leg press during brain functional magnetic resonance imaging (fMRI) to characterize bilateral motor control brain activity. Athletes also completed an established biomechanical assessment of ACL injury risk biomechanics within a 3D motion analysis laboratory. Knee abduction moments during landing were modelled as a covariate of interest within the fMRI analyses to identify directional relationships with brain activity and an injury-risk group classification analysis, based on established knee abduction moment cut-points. Greater landing knee abduction moments were associated with greater lingual gyrus, intracalcarine cortex, posterior cingulate cortex and precuneus activity when performing the bilateral leg press (all <jats:italic>z<\/jats:italic> &gt; 3.1, <jats:italic>p<\/jats:italic> &lt; .05; multiple comparison corrected). In the follow-up injury-risk classification analysis, those classified as high ACL injury-risk had greater activity in the lingual gyrus, parietal cortex and bilateral primary and secondary motor cortices relative to those classified as low ACL injury-risk (all <jats:italic>z<\/jats:italic> &gt; 3.1, <jats:italic>p<\/jats:italic> &lt; .05; multiple comparison corrected). In young female athletes, elevated brain activity for bilateral leg motor control in regions that integrate sensory, spatial, and attentional information were related to ACL injury-risk landing biomechanics. These data implicate crossmodal visual and proprioceptive integration brain activity and knee spatial awareness as potential neurotherapeutic targets to optimize ACL injury-risk reduction strategies.<\/jats:p>","DOI":"10.1371\/journal.pone.0272578","type":"journal-article","created":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T17:34:23Z","timestamp":1660239263000},"page":"e0272578","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":25,"title":["Preliminary brain-behavioral neural correlates of anterior cruciate ligament injury risk landing biomechanics\u00a0using a novel\u00a0bilateral leg press neuroimaging paradigm"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6102-8224","authenticated-orcid":true,"given":"Dustin R.","family":"Grooms","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jed 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D.","family":"Myer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,8,11]]},"reference":[{"key":"pone.0272578.ref001","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1136\/bjsports-2013-093398","article-title":"Fifty-five per cent return to competitive sport following anterior cruciate ligament reconstruction surgery: an updated systematic review and meta-analysis including aspects of physical functioning and contextual factors","volume":"48","author":"CL Ardern","year":"2014","journal-title":"British Journal of Sports Medicine"},{"key":"pone.0272578.ref002","doi-asserted-by":"crossref","first-page":"806","DOI":"10.4085\/1062-6050-49.3.35","article-title":"Osteoarthritis Prevalence Following Anterior Cruciate Ligament Reconstruction: A Systematic Review and Numbers-Needed-to-Treat Analysis","volume":"49","author":"B Luc","year":"2014","journal-title":"Journal of Athletic Training"},{"key":"pone.0272578.ref003","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1177\/0363546504269591","article-title":"Biomechanical measures of neuromuscular control and valgus loading of the knee predict anterior cruciate ligament injury risk in female athletes: a prospective study.","volume":"33","author":"TE Hewett","year":"2005","journal-title":"Am J Sports Med"},{"key":"pone.0272578.ref004","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1177\/0363546516665810","article-title":"Stiff Landings Are Associated With Increased ACL Injury Risk in Young Female Basketball and Floorball Players.","volume":"45","author":"M Lepp\u00e4nen","year":"2017","journal-title":"Am J Sports Med."},{"key":"pone.0272578.ref005","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s40279-013-0135-9","article-title":"Dosage Effects of Neuromuscular Training Intervention to Reduce Anterior Cruciate Ligament Injuries in Female Athletes: Meta- and Sub-Group Analyses.","volume":"44","author":"D Sugimoto","year":"2014","journal-title":"Sports Medicine."},{"key":"pone.0272578.ref006","first-page":"450","article-title":"Neuromuscular control training programs and noncontact anterior cruciate ligament injury rates in female athletes: a numbers-needed-to-treat analysis","volume":"41","author":"TL Grindstaff","year":"2006","journal-title":"Journal of athletic training"},{"key":"pone.0272578.ref007","article-title":"Meta-analysis of meta-analyses of anterior cruciate ligament injury reduction training programs","author":"KE Webster","journal-title":"Journal of Orthopaedic Research"},{"key":"pone.0272578.ref008","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1136\/bjsports-2011-090895","article-title":"Evaluation of the effectiveness of neuromuscular training to reduce anterior cruciate ligament injury in female athletes: a critical review of relative risk reduction and numbers-needed-to-treat analyses","volume":"46","author":"D Sugimoto","year":"2012","journal-title":"British Journal of Sports Medicine"},{"key":"pone.0272578.ref009","doi-asserted-by":"crossref","first-page":"e20161877","DOI":"10.1542\/peds.2016-1877","article-title":"ACL Tears in School-Aged Children and Adolescents Over 20 Years.","volume":"139","author":"NA Beck","year":"2017","journal-title":"Pediatrics"},{"key":"pone.0272578.ref010","article-title":"Does brain functional connectivity contribute to musculoskeletal injury? A preliminary prospective analysis of a neural biomarker of ACL injury risk","author":"JA Diekfuss","year":"2018","journal-title":"Journal of Science and Medicine in Sport"},{"key":"pone.0272578.ref011","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.4085\/1062-6050-50.10.08","article-title":"\u201cBuz.\u201d Brains and Sprains: The Brain\u2019s Role in Noncontact Anterior Cruciate Ligament Injuries.","volume":"50","author":"C Swanik","year":"2015","journal-title":"J Athl Train."},{"key":"pone.0272578.ref012","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1177\/0363546511425474","article-title":"Retention of Movement Pattern Changes After a Lower Extremity Injury Prevention Program Is Affected by Program Duration.","volume":"40","author":"DA Padua","year":"2012","journal-title":"The American Journal of Sports Medicine"},{"key":"pone.0272578.ref013","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/3480512","article-title":"Functional Brain Plasticity Associated with ACL Injury: A Scoping Review of Current Evidence.","volume":"2019","author":"T Neto","year":"2019","journal-title":"Neural Plasticity"},{"key":"pone.0272578.ref014","article-title":"Systematic video analysis of ACL injuries in professional male football (soccer): injury mechanisms, situational patterns and biomechanics study on 134 consecutive cases.","author":"FD Villa","year":"2020","journal-title":"Br J Sports Med."},{"key":"pone.0272578.ref015","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1177\/0363546506293899","article-title":"Mechanisms of anterior cruciate ligament injury in basketball: video analysis of 39 cases.","volume":"35","author":"T Krosshaug","year":"2007","journal-title":"Am J Sports Med"},{"key":"pone.0272578.ref016","article-title":"Alterations in knee sensorimotor brain functional connectivity contributes to ACL injury in male high-school football players: a prospective neuroimaging analysis.","author":"JA Diekfuss","year":"2019","journal-title":"Brazilian Journal of Physical Therapy"},{"key":"pone.0272578.ref017","doi-asserted-by":"crossref","first-page":"502","DOI":"10.2519\/jospt.2008.2761","article-title":"Decreased Quadriceps Activation Measured Hours Prior to a Noncontact Anterior Cruciate Ligament Tear.","volume":"38","author":"TL Grindstaff","year":"2008","journal-title":"Journal of Orthopaedic & Sports Physical Therapy."},{"key":"pone.0272578.ref018","doi-asserted-by":"crossref","first-page":"e13530","DOI":"10.1111\/psyp.13530","article-title":"Electrocortical dynamics differentiate athletes exhibiting low- and high- ACL injury risk biomechanics.","volume":"57","author":"S Bonnette","year":"2020","journal-title":"Psychophysiology"},{"key":"pone.0272578.ref019","doi-asserted-by":"crossref","first-page":"180","DOI":"10.2519\/jospt.2017.7003","article-title":"Neuroplasticity Associated With Anterior Cruciate Ligament Reconstruction.","volume":"47","author":"DR Grooms","year":"2017","journal-title":"J Orthop Sports Phys Ther"},{"key":"pone.0272578.ref020","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1177\/0363546509343201","article-title":"Anterior Cruciate Ligament Deficiency Causes Brain Plasticity: A Functional MRI Study.","volume":"37","author":"E Kapreli","year":"2009","journal-title":"Am J Sports Med"},{"key":"pone.0272578.ref021","doi-asserted-by":"crossref","first-page":"134985","DOI":"10.1016\/j.neulet.2020.134985","article-title":"Neural activity for hip-knee control in those with anterior cruciate ligament reconstruction: A task-based functional connectivity analysis","volume":"730","author":"CR Criss","year":"2020","journal-title":"Neuroscience Letters"},{"key":"pone.0272578.ref022","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1600-0838.2007.00702.x","article-title":"Changed cortical activity after anterior cruciate ligament reconstruction in a joint position paradigm: an EEG study.","volume":"18","author":"J Baumeister","year":"2008","journal-title":"Scand J Med Sci Sports"},{"key":"pone.0272578.ref023","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1002\/jor.21380","article-title":"Altered electrocortical brain activity after ACL reconstruction during force control","volume":"29","author":"J Baumeister","year":"2011","journal-title":"J Orthop Res"},{"key":"pone.0272578.ref024","first-page":"8","article-title":"Brain activation associated with active and passive lower limb stepping","author":"L Jaeger","year":"2014","journal-title":"Front Hum Neurosci"},{"key":"pone.0272578.ref025","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1123\/mcj.16.2.158","article-title":"The Effect of Movement Rate and Complexity on Functional Magnetic Resonance Signal Change during Pedaling.","volume":"16","author":"JP Mehta","year":"2012","journal-title":"Motor Control."},{"key":"pone.0272578.ref026","doi-asserted-by":"crossref","first-page":"2325967120946328","DOI":"10.1177\/2325967120946328","article-title":"Single-Leg Squat After Anterior Cruciate Ligament Reconstruction: An Analysis of the Knee Valgus Angle at 6 and 12 Months.","volume":"8","author":"LM Batty","year":"2020","journal-title":"Orthopaedic Journal of Sports Medicine"},{"key":"pone.0272578.ref027","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s00167-009-0892-z","article-title":"Differences in kinematics of single leg squatting between anterior cruciate ligament-injured patients and healthy controls","volume":"18","author":"J Yamazaki","year":"2010","journal-title":"Knee Surgery, Sports Traumatology, Arthroscopy."},{"key":"pone.0272578.ref028","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1080\/15438627.2015.1076413","article-title":"Differences and correlations in knee and hip mechanics during single-leg landing, single-leg squat, double-leg landing, and double-leg squat tasks.","volume":"23","author":"MR Donohue","year":"2015","journal-title":"Research in Sports Medicine"},{"key":"pone.0272578.ref029","first-page":"1211","article-title":"Bilateral kinematic and kinetic analysis of the squat exercise after anterior cruciate ligament reconstruction.","volume":"84","author":"GJ Salem","year":"2003","journal-title":"Archives of physical medicine and rehabilitation."},{"key":"pone.0272578.ref030","first-page":"12","volume":"38","author":"MV Paterno","year":"2010","journal-title":"Biomechanical Measures During Landing and Postural Stability Predict Second Anterior Cruciate Ligament Injury After Anterior Cruciate Ligament Reconstruction and Return to Sport"},{"key":"pone.0272578.ref031","doi-asserted-by":"crossref","first-page":"e000311","DOI":"10.1136\/bmjsem-2017-000311","article-title":"Association between frontal plane knee control and lower extremity injuries: a prospective study on young team sport athletes.","volume":"4","author":"AM R\u00e4is\u00e4nen","year":"2018","journal-title":"BMJ Open Sport & Exercise Medicine."},{"key":"pone.0272578.ref032","article-title":"Bilateral Squatting Mechanics Are Associated With Landing Mechanics in Anterior Cruciate Ligament Reconstruction Patients.","author":"AT Peebles","year":"2021","journal-title":"Am J Sports Med."},{"key":"pone.0272578.ref033","doi-asserted-by":"crossref","first-page":"109108","DOI":"10.1016\/j.jneumeth.2021.109108","article-title":"Integrated 3D motion analysis with functional magnetic resonance neuroimaging to identify neural correlates of lower extremity movement","volume":"355","author":"M Anand","year":"2021","journal-title":"Journal of Neuroscience Methods"},{"key":"pone.0272578.ref034","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/jon.12645","article-title":"A Novel Approach to Evaluate Brain Activation for Lower Extremity Motor Control.","volume":"29","author":"DR Grooms","year":"2019","journal-title":"Journal of Neuroimaging"},{"key":"pone.0272578.ref035","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1177\/1941738111410180","article-title":"Sex Differences in Knee Abduction During Landing: A Systematic Review.","volume":"3","author":"DW Carson","year":"2011","journal-title":"Sports Health: A Multidisciplinary Approach."},{"key":"pone.0272578.ref036","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1136\/bjsm.2009.069351","article-title":"Biomechanics laboratory-based prediction algorithm to identify female athletes with high knee loads that increase risk of ACL injury","volume":"45","author":"GD Myer","year":"2011","journal-title":"British Journal of Sports Medicine"},{"key":"pone.0272578.ref037","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1006\/nimg.1995.1018","article-title":"Characterizing Evoked Hemodynamics with fMRI.","volume":"2","author":"KJ Friston","year":"1995","journal-title":"NeuroImage."},{"key":"pone.0272578.ref038","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1249\/mss.0b013e318149332d","article-title":"Reliability of Landing 3D Motion Analysis: Implications for Longitudinal Analyses.","volume":"39","author":"KR Ford","year":"2007","journal-title":"Medicine & Science in Sports & Exercise."},{"key":"pone.0272578.ref039","doi-asserted-by":"crossref","first-page":"S208","DOI":"10.1016\/j.neuroimage.2004.07.051","article-title":"Advances in functional and structural MR image analysis and implementation as FSL.","volume":"23","author":"SM Smith","year":"2004","journal-title":"NeuroImage"},{"key":"pone.0272578.ref040","doi-asserted-by":"crossref","first-page":"10765","DOI":"10.1073\/pnas.132272199","article-title":"Cerebral energetics and spiking frequency: the neurophysiological basis of fMRI","volume":"99","author":"AJ Smith","year":"2002","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"pone.0272578.ref041","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1006\/nimg.2002.1132","article-title":"Improved Optimization for the Robust and Accurate Linear Registration and Motion Correction of Brain Images.","volume":"17","author":"M Jenkinson","year":"2002","journal-title":"NeuroImage"},{"key":"pone.0272578.ref042","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1006\/nimg.2001.0931","article-title":"Temporal Autocorrelation in Univariate Linear Modeling of FMRI Data.","volume":"14","author":"MW Woolrich","year":"2001","journal-title":"NeuroImage"},{"key":"pone.0272578.ref043","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1038\/jcbfm.2010.86","article-title":"Everything you never wanted to know about circular analysis, but were afraid to ask","volume":"30","author":"N Kriegeskorte","year":"2010","journal-title":"J Cereb Blood Flow Metab"},{"key":"pone.0272578.ref044","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nn.2303","article-title":"Circular analysis in systems neuroscience: the dangers of double dipping","volume":"12","author":"N Kriegeskorte","year":"2009","journal-title":"Nat Neurosci"},{"key":"pone.0272578.ref045","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1460-9568.2005.04176.x","article-title":"The role of anterior cingulate cortex and precuneus in the coordination of motor behaviour","volume":"22","author":"N Wenderoth","year":"2005","journal-title":"European Journal of Neuroscience"},{"key":"pone.0272578.ref046","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/brain\/awl004","article-title":"The precuneus: a review of its functional anatomy and behavioural correlates","volume":"129","author":"AE Cavanna","year":"2006","journal-title":"Brain"},{"key":"pone.0272578.ref047","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.cortex.2015.07.014","article-title":"Visual processing of optic flow and motor control in the human posterior cingulate sulcus.","volume":"71","author":"DT Field","year":"2015","journal-title":"Cortex"},{"key":"pone.0272578.ref048","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1093\/cercor\/bhs329","article-title":"Neuroimaging evidence of the anatomo-functional organization of the human cingulate motor areas","volume":"24","author":"C Amiez","year":"2014","journal-title":"Cereb Cortex"},{"key":"pone.0272578.ref049","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1523\/JNEUROSCI.0060-14.2014","article-title":"A Motor-Oriented Organization of Human Ventral Visual Cortex?","volume":"34","author":"JP Gallivan","year":"2014","journal-title":"J Neurosci"},{"key":"pone.0272578.ref050","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/nn1241","article-title":"Extrastriate body area in human occipital cortex responds to the performance of motor actions","volume":"7","author":"SV Astafiev","year":"2004","journal-title":"Nat Neurosci"},{"key":"pone.0272578.ref051","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1126\/science.289.5482.1206","article-title":"Modulation of human visual cortex by crossmodal spatial attention","volume":"289","author":"E Macaluso","year":"2000","journal-title":"Science"},{"key":"pone.0272578.ref052","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1093\/cercor\/11.12.1110","article-title":"Crossmodal Processing in the Human Brain: Insights from Functional Neuroimaging Studies","volume":"11","author":"GA Calvert","year":"2001","journal-title":"Cereb Cortex"},{"key":"pone.0272578.ref053","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S1364-6613(98)01188-7","article-title":"Attention and the crossmodal construction of space.","volume":"2","author":"J Driver","year":"1998","journal-title":"Trends in cognitive sciences."},{"key":"pone.0272578.ref054","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1523\/JNEUROSCI.3987-15.2016","article-title":"Integration of Visual and Proprioceptive Limb Position Information in Human Posterior Parietal, Premotor, and Extrastriate Cortex","volume":"36","author":"J Limanowski","year":"2016","journal-title":"J Neurosci"},{"key":"pone.0272578.ref055","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1177\/0363546507299532","article-title":"The relationship between neurocognitive function and noncontact anterior cruciate ligament injuries.","volume":"35","author":"CB Swanik","year":"2007","journal-title":"Am J Sports Med"},{"key":"pone.0272578.ref056","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1123\/ijatt.17.6.4","article-title":"Neurocognitive Reaction Time Predicts Lower Extremity Sprains and Strains.","volume":"17","author":"Gary B. Wilkerson","year":"2012","journal-title":"International Journal of Athletic Therapy and Training"},{"key":"pone.0272578.ref057","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1177\/0363546516657338","article-title":"Drop-Jump Landing Varies With Baseline Neurocognition: Implications for Anterior Cruciate Ligament Injury Risk and Prevention.","volume":"44","author":"DC Herman","year":"2016","journal-title":"Am J Sports Med."},{"key":"pone.0272578.ref058","article-title":"Visual-Spatial Memory Deficits Are Related to Increased Knee Valgus Angle During a Sport-Specific Sidestep Cut.","author":"SM Monfort","year":"2019","journal-title":"The American Journal of Sports Medicine"},{"key":"pone.0272578.ref059","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1007\/s00221-014-3963-4","article-title":"Bilateral motor tasks involve more brain regions and higher neural activation than unilateral tasks: an fMRI study","volume":"232","author":"JW Noble","year":"2014","journal-title":"Exp Brain Res"},{"key":"pone.0272578.ref060","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1006\/nimg.2002.1183","article-title":"A Blueprint for Target Motion: fMRI Reveals Perceived Sequential Complexity to Modulate Premotor Cortex.","volume":"16","author":"RI Schubotz","year":"2002","journal-title":"NeuroImage"},{"key":"pone.0272578.ref061","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1123\/jsr.2018-0237","article-title":"High-Risk Lower-Extremity Biomechanics Evaluated in Simulated Soccer-Specific Virtual Environments","volume":"29","author":"CA DiCesare","year":"2020","journal-title":"Journal of Sport Rehabilitation"},{"key":"pone.0272578.ref062","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0301-0511(00)00047-8","article-title":"Neuro-cognitive activity during a self-paced visuospatial task: comparative EEG profiles in marksmen and novice shooters.","volume":"53","author":"AJ Haufler","year":"2000","journal-title":"Biological psychology."},{"key":"pone.0272578.ref063","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/WNN.0000000000000042","article-title":"An fMRI study of differences in brain activity among elite, expert, and novice archers at the moment of optimal aiming.","volume":"27","author":"W Kim","year":"2014","journal-title":"Cognitive and Behavioral Neurology."},{"key":"pone.0272578.ref064","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.neulet.2011.06.045","article-title":"Cortical fMRI activation to opponents\u2019 body kinematics in sport-related anticipation: Expert-novice differences with normal and point-light video","volume":"500","author":"MJ Wright","year":"2011","journal-title":"Neuroscience Letters"},{"key":"pone.0272578.ref065","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1113\/jphysiol.2007.142661","article-title":"The olympic brain. Does corticospinal plasticity play a role in acquisition of skills required for high-performance sports?: The olympic brain","volume":"586","author":"JB Nielsen","year":"2008","journal-title":"The Journal of Physiology"},{"key":"pone.0272578.ref066","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.brainresbull.2009.02.001","article-title":"\u201cNeural efficiency\u201d of athletes\u2019 brain for upright standing: a high-resolution EEG study.","volume":"79","author":"C Del Percio","year":"2009","journal-title":"Brain Res Bull"},{"key":"pone.0272578.ref067","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.intell.2013.09.005","article-title":"Neural efficiency as a function of task demands.","volume":"42","author":"B Dunst","year":"2014","journal-title":"Intelligence"},{"key":"pone.0272578.ref068","article-title":"Visual-Cognition Associated with Knee Proprioception, Time to Stability, and Sensory Integration Neural Activity after ACL Reconstruction","author":"M Chaput","journal-title":"Journal of Orthopaedic Research"},{"key":"pone.0272578.ref069","article-title":"Practical Training Strategies to Apply Neuro-Mechanistic Motor Learning Principles to Facilitate Adaptations Towards Injury-Resistant Movement in Youth.","author":"JA Diekfuss","year":"2020","journal-title":"J of SCI IN SPORT AND EXERCISE."},{"key":"pone.0272578.ref070","article-title":"Can We Capitalize on Central Nervous System Plasticity in Young Athletes to Inoculate Against Injury?","author":"JA Diekfuss","year":"2020","journal-title":"J of SCI IN SPORT AND EXERCISE."},{"key":"pone.0272578.ref071","volume":"20","author":"JA Diekfuss","journal-title":"Targeted Application of Motor Learning Theory to Leverage Youth 3 Neuroplasticity for Enhanced Injury\u2011Resistance and Exercise 4 Performance: OPTIMAL PREP."},{"key":"pone.0272578.ref072","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.3758\/s13423-015-0999-9","article-title":"Optimizing performance through intrinsic motivation and attention for learning: The OPTIMAL theory of motor learning.","volume":"23","author":"G Wulf","year":"2016","journal-title":"Psychon Bull Rev"},{"key":"pone.0272578.ref073","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.humov.2019.04.001","article-title":"The effects of instructional cues on performance and mechanics during a gross motor movement","volume":"66","author":"LD Raisbeck","year":"2019","journal-title":"Human Movement Science"},{"key":"pone.0272578.ref074","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/14763141.2019.1584237","article-title":"Training rugby athletes with an external attentional focus promotes more automatic adaptions in landing forces.","volume":"18","author":"TL Widenhoefer","year":"2019","journal-title":"Sports Biomechanics"},{"key":"pone.0272578.ref075","first-page":"1","article-title":"The Effects of Attentional Focus Instructions Specific to Body Movements on Movement 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anterior cruciate ligament injury: a framework for visual-motor training approaches in rehabilitation","volume":"45","author":"D Grooms","year":"2015","journal-title":"J Orthop Sports Phys Ther"},{"key":"pone.0272578.ref086","first-page":"26","article-title":"Stroboscopic Vision to Induce Sensory Reweighting During Postural Control","author":"K-M Kim","year":"2017","journal-title":"Journal of Sport Rehabilitation"},{"key":"pone.0272578.ref087","first-page":"1","article-title":"An early review of stroboscopic visual training: insights, challenges and accomplishments to guide future studies.","author":"L Wilkins","year":"2019","journal-title":"International Review of Sport and Exercise Psychology."},{"key":"pone.0272578.ref088","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1177\/0363546512437850","article-title":"Dynamic sagittal plane trunk control during anterior cruciate ligament injury.","volume":"40","author":"FT Sheehan","year":"2012","journal-title":"Am J Sports Med"},{"key":"pone.0272578.ref089","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1111\/sms.13013","article-title":"A prospective investigation to evaluate risk factors for lower extremity injury risk in male youth soccer players.","volume":"28","author":"PJ Read","year":"2018","journal-title":"Scand J Med Sci Sports"},{"key":"pone.0272578.ref090","doi-asserted-by":"crossref","first-page":"936","DOI":"10.26603\/ijspt20200936","article-title":"VALIDITY OF AN MRI-COMPATIBLE MOTION CAPTURE SYSTEM FOR USE WITH LOWER EXTREMITY NEUROIMAGING PARADIGMS.","volume":"15","author":"M Anand","year":"2020","journal-title":"Int J Sports Phys Ther"},{"key":"pone.0272578.ref091","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.neuroimage.2008.07.001","article-title":"Reliable assessment of lower limb motor representations with fMRI: Use of a novel MR compatible device for real-time monitoring of ankle, knee and hip torques.","volume":"43","author":"JM 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